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B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma
BackgroundInvasive adenocarcinoma (IAC), which is typically preceded by minimally invasive adenocarcinoma (MIA), is the dominant pathological subtype...
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Approaches to identify canine distemper virus with neurological symptoms on the basis of molecular characterization of hemagglutinin and fusion genes
Canine distemper virus (CDV), which causes severe infections in all domestic and wild carnivores, is transmitted by all secretions and excretions of...
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CSF N-Glycomics Using High-Throughput UPLC-ESI Techniques in Alzheimer’s Disease
In this chapter, we will present a high-throughput method applied in our laboratory for the structural elucidation of the cerebrospinal fluid (CSF)...
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HIV-1 subtype C Envelope function becomes less sensitive to N-glycosylation deletion during disease progression
ObjectiveAs part of a larger study to understand how Envelope N -glycosylation influences HIV-1 pathogenesis, we selected a participant infected with...
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Significance of FUT8 in Pancreatic Cancer and Others
Abnormal changes in glycosylation have been positively correlated with tumorigenesis and progression in cancer. In particular, an elevation in the...
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Pancreatic Cancer: Pursuit of Mucins from Progression to Prognosis
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by a late diagnosis, poor survival, and limited treatment options....
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Compound heterozygous variants in MAN2B2 identified in a Chinese child with congenital disorders of glycosylation
Congenital disorders of glycosylation (CDG) is a group inherited disorders. It is characterized by multi-organ dysfunction with significant morbidity...
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Glycosyltransferase GLT8D1 and GLT8D2 serve as potential prognostic biomarkers correlated with Tumor Immunity in Gastric Cancer
BackgroundGlycosylation involved in various biological function, aberrant glycosylation plays an important role in cancer development and...
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Antigenic comparison of the neuraminidases from recent influenza A vaccine viruses and 2019–2020 circulating strains
Although viral-based influenza vaccines contain neuraminidase (NA or N) antigens from the recommended seasonal strains, NA is not extensively...
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Genetic characteristics of human coronavirus HKU1 in mainland China during 2018
Human coronavirus HKU1 (HCoV-HKU1) is a pathogen that causes acute respiratory tract infections in children and circulates worldwide. To investigate...
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Non B Cell-Derived Immunoglobulins in Lung Epithelial Cells and Lung Cancer
As the locus for air exchange, lung tissue is perpetually exposed to a significant quantity of foreign pathogens. Consequently, lung has developed a...
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Host sex disparity and viral genotype dependence of the glycosylation level of small Hepatitis B surface protein in patients with HBeAg-positive chronic Hepatitis B
BackgroundHepatitis B surface antigen (HBsAg) consists of six components of large/middle/small HBs proteins (L/M/SHBs) with non-glycosylated (ng)- or...
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CCDC88C, an O-GalNAc glycosylation substrate of GALNT6, drives breast cancer metastasis by promoting c-JUN-mediated CEMIP transcription
Coiled-coil domain containing 88C (CCDC88C) is a component of non-canonical Wnt signaling, and its dysregulation causes colorectal cancer metastasis....
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SLC10A7, an orphan member of the SLC10 family involved in congenital disorders of glycosylation
SLC10A7, encoded by the so-called SLC10A7 gene, is the seventh member of a human sodium/bile acid cotransporter family, known as the SLC10 family....
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Characterization of an envelope protein 118L in invertebrate iridescent virus 6 (IIV6)
Invertebrate iridescent virus 6 (IIV6) is a nucleocytoplasmic insect virus and a member of the family Iridoviridae . The IIV6 genome consists of...
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Role of Wisteria floribunda agglutinin binding glycans in carcinogenesis and metastasis of cholangiocarcinoma
Aberrant glycosylation is an important factor in facilitating tumor progression and therapeutic resistance. In this study, using Wisteria floribunda ...
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Genetic analysis of human parainfluenza type 2 virus in Riyadh, Saudi Arabia
The extensive mass gathering of pilgrims from all over the world, as well as the constant flow of foreign workers via country entry crossings, raises...
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Elevated transcription and glycosylation of B3GNT5 promotes breast cancer aggressiveness
BackgroundBasal-like breast cancer (BLBC) is the most aggressive subtype of breast cancer because of its aggressive biological characteristics and no...
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Genetic diversity and bioinformatic analysis in the L1 gene of HPV genotypes 31, 33, and 58 circulating in women with normal cervical cytology
BackgroundHPV-31, -33, and -58, along with HPV-45 and -52, account for almost 11% of HPV-associated cancers. Our previous studies showed that after...
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Pancreatic Cancer: Pursuit of Mucins from Progression to Prognosis
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by a late diagnosis, poor survival, and limited treatment options....