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High-throughput biochemistry in RNA sequence space: predicting structure and function
RNAs are central to fundamental biological processes in all known organisms. The set of possible intramolecular interactions of RNA nucleotides...
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Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant
In binocular animals that exhibit stereoscopic visual responses, the axons of retinal ganglion cells (RGCs) connect to brain areas bilaterally by...
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Long-term labeling and imaging of synaptically connected neuronal networks in vivo using double-deletion-mutant rabies viruses
Rabies-virus-based monosynaptic tracing is a widely used technique for map** neural circuitry, but its cytotoxicity has confined it primarily to...
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Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice
Whole-brain genome editing to correct single-base mutations and reduce or reverse behavioral changes in animal models of autism spectrum disorder...
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Isolation and molecular characterization of a tomato brown rugose fruit virus mutant breaking the tobamovirus resistance found in wild Solanum species
A new tobamovirus named tomato brown rugose fruit virus (ToBRFV) overcomes the effect of the Tm-1 , Tm-2 , and Tm-2 2 resistance genes introgressed from...
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Sequence dependencies and mutation rates of localized mutational processes in cancer
BackgroundCancer mutations accumulate through replication errors and DNA damage coupled with incomplete repair. Individual mutational processes often...
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Specific TCR profiles predict clinical outcome of adjuvant EGFR-TKIs for resected EGFR-mutant non-small cell lung cancer
BackgroundADJUVANT-CTONG1104 reported a favorable survival outcome from adjuvant gefitinib treatment over chemotherapy in EGFR -mutant non-small cell...
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Human Pro370Leu Mutant Myocilin Induces the Phenotype of Open-Angle Glaucoma in Transgenic Mice
To investigate the characteristics of mutation myocilin proteins and glaucoma pathological phenotype in transgenic mice with full-length human...
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Enhancing structural plasticity of PC12 neurons during differentiation and neurite regeneration with a catalytically inactive mutant version of the zRICH protein
BackgroundStudies of the molecular mechanisms of nerve regeneration have led to the discovery of several proteins that are induced during successful...
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Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes
BackgroundMajority of chondrosarcomas are associated with a number of genetic alterations, including somatic mutations in isocitrate dehydrogenase 1 (
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Differential chromatin accessibility landscape of gain-of-function mutant p53 tumours
BackgroundMutations in TP53 not only affect its tumour suppressor activity but also exerts oncogenic gain-of-function activity. While the genome-wide...
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Neoadjuvant pembrolizumab, dabrafenib and trametinib in BRAFV600-mutant resectable melanoma: the randomized phase 2 NeoTrio trial
Immune checkpoint inhibitors and BRAF-targeted therapy each improve survival in melanoma. Immune changes early during targeted therapy suggest the...
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Gastrointestinal microbiota profile and clinical correlations in advanced EGFR-WT and EGFR-mutant non-small cell lung cancer
IntroductionDifference in clinical responses to cancer therapy in each patient is from several factors. Gastrointestinal microbiota is one of the...
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The influence of a modified p53 C-terminal peptide by using a tumor-targeting sequence on cellular apoptosis and tumor treatment
The restoration of the function of p53 in tumors is a therapeutic strategy for the highly frequent mutation of the TP53 tumor suppressor gene. P460...
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Enhancing Cohort PASA Efficiency from Lessons Assimilated by Mutant Genoty** in C. elegans
Classical restriction fragment length polymorphism (RFLP) and sequencing are labor-intensive and expensive methods to study single base changes,...
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Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting
As the progression of low-grade diffuse astrocytomas into grade 4 tumors significantly impacts patient prognosis, a better understanding of this...
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Clinical feature-related single-base substitution sequence signatures identified with an unsupervised machine learning approach
BackgroundMutation processes leave different signatures in genes. For single-base substitutions, previous studies have suggested that mutation...
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Nutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2
BackgroundOncogenic KRAS mutation, the most frequent mutation in non-small cell lung cancer (NSCLC), is an aggressiveness risk factor and leads to...
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Potential benefit of osimertinib plus bevacizumab in leptomeningeal metastasis with EGFR mutant non-small-cell lung cancer
BackgroundEGFR-mutant non-small cell lung cancer (NSCLC) is prone to leptomeningeal metastasis (LM) after Tyrosine kinase inhibitors (TKIs)...
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Structure-guided discovery of highly efficient cytidine deaminases with sequence-context independence
The applicability of cytosine base editors is hindered by their dependence on sequence context and by off-target effects. Here, by using AlphaFold2...
