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Macrolides for Rhinosinusitis and Nasal Polyps
Low-dose and long-term administration of a 14- or 15-membered ring macrolide (macrolide therapy) is well known to be effective in the treatment of...
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Gastro-protective effects and anti-Helicobacter pylori activities of the aqueous and methanol extracts of the stem-back of Nauclea pobeguinii (Rubiaceae)
Nauclea pobeguinii ( N. pobeguinii ) is a plant used in African medicine to treat many gastroduodenal diseases. In this study, we determined the...
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Antiulcerogenic and healing activity of hecogenin acetate in rodents
Peptic ulcers are lesions in the gastric and duodenal mucosa generated by an imbalance between protective factors (gastroduodenal mucus secretion,...
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Histological study of diurnal changes in bacterial settlement in the rat alimentary tract
The composition of fecal bacteria is reported to change throughout the day, whereas the circadian rhythmicity of indigenous bacteria that settle on...
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Aquaporins in Respiratory System
Aquaporins (AQPs) are water channel proteins facilitating fluid transport in alveolar space, airway humidification, pleural fluid absorption, and...
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Exposure to Sodium Hypochlorite or Cigarette Smoke Induces Lung Injury and Mechanical Impairment in Wistar Rats
Pulmonary irritants, such as cigarette smoke (CS) and sodium hypochlorite (NaClO), are associated to pulmonary diseases in cleaning workers. We...
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Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract
Inflammatory airway diseases like cystic fibrosis, asthma and COVID-19 are characterized by high levels of pulmonary cytokines. Two well-established...
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PDE5 inhibitors and gastric mucosa: implications for the management of peptic ulcer disease
Peptic ulcer disease (PUD) continues to be a cause of significant morbidity and mortality worldwide. Almost two-thirds of PUD cases are asymptomatic....
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Physiologic Influences of Transepithelial K+ Secretion
Cellular ionic balance relies on ion channels and coupled transporters to maintain and use the transmembrane electrochemical gradients of the cations...
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Metabolism Pharmacology
Safety pharmacology defines studies that investigate the potential undesirable pharmacodynamic effects of a substance on physiological functions in...
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Impact of high-altitude hypoxia on Helicobacter pylori-induced gastritis pathological manifestations and inflammatory responses
BackgroundChronic gastritis caused by Helicobacter pylori (Hp) infection is a common gastrointestinal disorder. Despite the high prevalence of Hp...
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Novel Drug Delivery Approaches for the Localized Treatment of Cervical Cancer
Cervical cancer (CC) is the fourth leading cancer type in females globally. Being an ailment of the birth canal, primitive treatment strategies,...
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Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects
Reactive oxygen species (ROS) generated by NADPH oxidases (NOX/DUOX) provide antimicrobial defense, redox signaling, and gut barrier maintenance....
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Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling pathway
Asthma is a common respiratory disease, and immune system dysregulation has direct relevance to asthma pathogenesis. Probiotics and prebiotics have...
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The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation
Interleukin 5 (IL-5) plays crucial roles in type 2-high asthma by mediating eosinophil maturation, activation, chemotaxis and survival. Inhibition of...
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Mucin O-glycan-microbiota axis orchestrates gut homeostasis in a diarrheal pig model
BackgroundPost-weaning diarrhea in piglets reduces growth performance and increases mortality, thereby causing serious economic losses. The...
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Activating transcription factor 5 (ATF5) controls intestinal tuft and goblet cell expansion upon succinate-induced type 2 immune responses in mice
Intestinal tuft cells, a chemosensory cell type in mucosal epithelia that secrete interleukin (IL)-25, play a pivotal role in type 2 immune responses...
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ITGAM-macrophage modulation as a potential strategy for treating neutrophilic Asthma: insights from bioinformatics analysis and in vivo experiments
AbstractIdentification of molecular biomarkers associated with neutrophilic asthma (NA) phenotype may inform the discovery of novel pathobiological...
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Drug Delivery in Respiratory Diseases: Current Opportunities, Molecular and Cellular Mechanism, and Future Challenges
Respiratory diseases are a major cause of concern throughout the world. Lung cancer, chronic obstructive pulmonary disease (COPD), and asthma deserve...
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A comparative study of IL-33 and its receptor ST2 in a C57BL/6 J mouse model of pulmonary Cryptococcus neoformans infection
It has been reported that IL-33 receptor ST2 deficiency mitigates Cryptococcus neoformans ( C. neoformans ) pulmonary infection in BALB/c mice. IL-33...
