Search
Search Results
-
Inhibiting Caveolin-1-Related Akt/mTOR Signaling Pathway Protects Against N-methyl-D-Aspartate Receptor Activation-Mediated Dysfunction of Blood–Brain Barrier in vitro
BackgroundThe aim of this study was to further explore the role of caveolin-1 (Cav-1) related Akt/mTOR signaling pathway in blood brain barrier (BBB)...
-
Morroniside improves AngII-induced cardiac fibroblast proliferation, migration, and extracellular matrix deposition by blocking p38/JNK signaling pathway through the downregulation of KLF5
Myocardial fibrosis (MF), which is an inevitable pathological manifestation of many cardiovascular diseases in the terminal stage, often contributes...
-
Uncovering the mechanism of resveratrol in the treatment of diabetic kidney disease based on network pharmacology, molecular docking, and experimental validation
BackgroundDiabetic kidney disease (DKD) has been the leading cause of chronic kidney disease in developed countries. Evidence of the benefits of...
-
HMGB1: A New Target for Ischemic Stroke and Hemorrhagic Transformation
Stroke in China is distinguished by its high rates of morbidity, recurrence, disability, and mortality. The ultra-early administration of rtPA is...
-
Screening of immune-related secretory proteins linking chronic kidney disease with calcific aortic valve disease based on comprehensive bioinformatics analysis and machine learning
BackgroundChronic kidney disease (CKD) is one of the most significant cardiovascular risk factors, playing vital roles in various cardiovascular...
-
Prevention of neointimal hyperplasia after coronary artery bypass graft via local delivery of sirolimus and rosuvastatin: network pharmacology and in vivo validation
BackgroundCoronary artery bypass graft (CABG) is generally used to treat complex coronary artery disease. Treatment success is affected by neointimal...
-
Inhibition of caspase-8 cascade restrains the osteoclastogenic fate of bone marrow cells
Osteoclasts are multinucleated cells of hematopoietic origin, with a pivotal role in bone development and remodeling. Failure in osteoclast...
-
Diagnosis and Drug Prediction of Parkinson’s Disease Based on Immune-Related Genes
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Immune mechanisms play an important role in the development of PD. The...
-
Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood–spinal cord barrier breakdown during acute spinal cord injury in rats
BackgroundNafamostat mesylate (nafamostat, NM) is an FDA-approved serine protease inhibitor that exerts anti-neuroinflammation and neuroprotective...
-
Molecular mechanism of lycorine in the treatment of glioblastoma based on network pharmacology and molecular docking
Lycorine is a naturally active alkaloid that has been shown to have inhibitory effects on a variety of cancers. However, the underlying mechanism of...
-
IRAK-M Regulates Proliferative and Invasive Phenotypes of Lung Fibroblasts
Lung fibroblasts play an important role in subepithelial fibrosis, one feature for airway remodeling. IL-1 receptor-associated kinase (IRAK)-M was...
-
Prospective cohort study reveals MMP-9, a neuroplasticity regulator, as a prediction marker of cochlear implantation outcome in prelingual deafness treatment
Because of vast variability of cochlear implantation outcomes in prelingual deafness treatment, identification of good and poor performers remains a...
-
Possibilities of Multilayer Perceptron in Complexing Risk Factors of Diabetic Foot Syndrome
The levels of markers of endothelial dysfunction, MMP9, and polymorphisms of genes of vascular tone regulation factors, platelet receptors, vascular...
-
Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway
BackgroundGout pain seriously affects the quality of patients' life. There is still no effective treatment. The inflammatory response is the main...
-
A novel role of FoxO3a in the migration and invasion of trophoblast cells: from metabolic remodeling to transcriptional reprogramming
BackgroundThe forkhead box O3a protein (FoxO3a) has been reported to be involved in the migration and invasion of trophoblast, but its underlying...
-
CCL5/CCR5-mediated peripheral inflammation exacerbates blood‒brain barrier disruption after intracerebral hemorrhage in mice
BackgroundOwing to metabolic disequilibrium and immune suppression, intracerebral hemorrhage (ICH) patients are prone to infections; according to a...
-
Gadolinium retention effect on macrophages — a potential cause of MRI contrast agent Dotarem toxicity
Gadolinium is a component of the MRI contrast agent Dotarem. Although Dotarem is the least toxic among MRI contrasts used, gadolinium present in...
-
The TFPI2–PPARγ axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic mice
BackgroundDiabetes mellitus is one of the causes of poor ventricular remodelling and poor cardiac recovery after myocardial infarction (MI). We...
-
The vasculogenic mimicry related signature predicts the prognosis and immunotherapy response in renal clear cell carcinoma
BackgroundClear cell carcinoma of the kidney is a common urological malignancy characterized by poor patient prognosis and treatment outcomes....
-
Effect of uniform capacitively coupled electric fields on matrix metabolism of osteoarthritic cartilage
BackgroundOsteoarthritis (OA) is a common and debilitating condition characterized by degeneration of hyaline cartilage. Currently, there is no...
