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Epigenetics in Cancer Biology
The term epigenetics dates back to the 1940s, when Conrad Waddington introduced it to refer to gene expression changes that occur during development...
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A Closer Overview of Phage Infections
Phage life cycles can be differentiated into adsorption, infection, and release stages. Not all adsorptions progress to infections, however, with...
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In vitro-Methoden
In diesem Kapitel werden gängige Methoden beschrieben, die in der Immunologie angewandt werden. Das Spektrum reicht von serologischen Verfahren (wie...
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Association of dietary intake and cervical cancer: a prevention strategy
IntroductionCervical cancer is one of lethal cancers in women. As a global concern, identifying important factors of cancer is a useful strategy for...
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DNA Methylation in Neurodegenerative Diseases
AbstractEpigenetic modifications in neurodegenerative diseases are just beginning to be studied; however, the growing interest in this phenomenon...
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The Human Genome and Its Variations
In this chapter, we will briefly describe the genetic adaption of anatomically modern humans due to migration from Africa to new geographic and...
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Assessment of biosafety and toxicity of hydrophilic gel for implantation in experimental in vitro and in vivo models
BackgroundThe assessment of biosafety of pharmacologically active substances is crucial for determining the feasibility of their medical use. There...
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A state-of-the-art review of the recent advances in exosome isolation and detection methods in viral infection
Proteins, RNA, DNA, lipids, and carbohydrates are only some of the molecular components found in exosomes released by tumor cells. They play an...
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Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring
Primary lung cancer is one of the most common malignant tumors in China. Approximately 60% of lung cancer patients have distant metastasis at the...
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The Concept of Immunogenetics
Genetics plays a major role in sha** the immune responses in both physiological and pathological states such as psoriasis, alopecia areata, and...
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Autophagy Gene BECN1 Intronic Variant rs9890617 Predisposes Individuals to Hepatitis B Virus Infection
Beclin 1 protein encoded by the BECN1 gene plays a critical role in the autophagy pathway which is utilized by the Hepatitis B virus (HBV) for its...
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Current advances of epigenetics in periodontology from ENCODE project: a review and future perspectives
BackgroundThe Encyclopedia of DNA Elements (ENCODE) project has advanced our knowledge of the functional elements in the genome and epigenome. The...
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Analysis on EZH2: mechanism identification of related CeRNA and its immunoassay in hepatocellular carcinoma
ObjectiveTo screen the possible potential signaling pathways related to enhancer of zeste homolog 2 (EZH2) based on ceRNA mechanism, and to analyze...
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Aktueller Stand der genomischen Karten: Genomische Selektion/GBV bei Nutztieren
Seit der ersten Sequenzierung des menschlichen Genoms im Jahr 2001 haben sich unsere Kenntnisse über den Aufbau des Genoms erheblich verbessert. Die...
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Krebsprävention
Krebspräventionsmaßnahmen können als primär, sekundär oder tertiär eingestuft werden. Die Prävention kann sich an ganze Populationen, an...
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Endogenous feline leukemia virus long terminal repeat integration site diversity is highly variable in related and unrelated domestic cats
Endogenous retroviruses (ERV) are indicators of vertebrate evolutionary history and play important roles as homeostatic regulators. ERV long terminal...
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The Distribution Characteristics of Microsatellites in the Transcriptome of Periplaneta americana
To obtain information of Periplaneta americana , we analyzed the distribution characteristics of microsatellite sequences in the P. americana ...
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A human specific Alu DNA cassette is found flanking the genes of transcription factor AP2
ObjectiveAlu elements are retroposons that invaded the primate genome and shaped its biology. Some Alus inserted recently and are polymorphic in the...
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Drug Resistance in Hepatocellular Carcinoma
At present, the burden of cancer morbidity and mortality is increasing all over the world. Among all kinds of cancer, primary liver cancer is...