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Human polyomavirus modulation of the host DNA damage response
The human DNA damage response (DDR) is a complex signaling network constituting many factors responsible for the preservation of genomic integrity....
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Determining host factors contributing to the reactivation of JC virus in kidney transplant recipients
Background and aimsThe John Cunningham virus (JCV) is the established etiological agent of the polyomavirus-associated nephropathy among renal...
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Specific and quantitative detection of Human polyomaviruses BKPyV and JCPyV in the healthy Pakistani population
BackgroundThe BK Polyomavirus (BKPyV) and JC polyomavirus (JCPyV) infections are widespread in human population and have been associated with severe...
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Exosome Content–Mediated Signaling Pathways in Multiple Sclerosis
Exosomes are small extracellular vesicles with a complex lipid-bilayer surface and 30–150 nm diameter. These vesicles play a critical role in...
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Viral vector: potential therapeutic for glioblastoma multiforme
Glioblastoma multiforme is a highly malignant primary brain tumour found in adults and is highlighted as the most devastating among all the other...
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The Role of Vesicle Trafficking and Release in Oligodendrocyte Biology
Oligodendrocytes are a subtype of glial cells found within the central nervous system (CNS), responsible for the formation and maintenance of...
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Analysis of variability of urinary excreted JC virus strains in patients infected with HIV and healthy donors
In immunocompromised individuals, especially in patients with T cell immunodeficiency, reactivation of JCPyV can cause serious life-threatening...
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Urinary MicroRNAs as Emerging Class of Noninvasive Biomarkers
MicroRNAs (miRNAs) are endogenous noncoding RNAs, which regulate gene expression on the post-transcriptional level. Since miRNAs are involved in the...
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Codon usage patterns of LT-Ag genes in polyomaviruses from different host species
BackgroundPolyomaviruses (PyVs) have a wide range of hosts, from humans to fish, and their effects on hosts vary. The differences in the infection...
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Efficient propagation of archetype JC polyomavirus in COS-7 cells: evaluation of rearrangements within the NCCR structural organization after transfection
John Cunningham virus (JCPyV) is an ubiquitous human pathogen that causes disease in immunocompromised patients. The JCPyV genome is composed of an...
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Interplay between Epstein-Barr virus infection and environmental xenobiotic exposure in cancer
Epstein-Barr virus (EBV) is a herpesvirus associated with lymphoid and epithelial malignancies. Both B cells and epithelial cells are susceptible and...
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Human polyomavirus KI, WU, BK, and JC in healthy volunteers
Despite the growing importance of infections caused by the human polyomaviruses (HPyVs), information about their transmission, pathogenesis, and...
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Fecal, oral, blood and skin virome of laboratory rabbits
Here, we investigated the fecal, oral, blood, and skin virome of 10 laboratory rabbits using a viral metagenomic method. In the oral samples, we...
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JC Polyomavirus Attachment and Entry: Potential Sites for PML Therapeutics
Purpose of ReviewJC polyomavirus (JCPyV) is a significant human pathogen that causes an asymptomatic infection in the kidney in the majority of the...
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Viral Cancer
Approximately 15-20% of human cancers have been shown to have a viral contribution. This chapter will discuss the role of retroviruses, hepatitis C...
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Antibody response to polyomavirus primary infection: high seroprevalence of Merkel cell polyomavirus and lymphoid tissue involvement
Human polyomaviruses (HPyVs) asymptomatically infect the human population establishing latency in the host, and their seroprevalence can reach 90% in...
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Pathology-supported genetic testing as a method for disability prevention in multiple sclerosis (MS). Part I. Targeting a metabolic model rather than autoimmunity
In this Review (Part I), we investigate the scientific evidence that multiple sclerosis (MS) is caused by the death of oligodendrocytes, the cells...
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Promoter activity of Merkel cell Polyomavirus variants in human dermal fibroblasts and a Merkel cell carcinoma cell line
BackgroundMerkel cell polyomavirus (MCPyV) is a human polyomavirus that establishes a life-long harmless infection in most individuals, with dermal...
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MicroRNAs and Their Role in Viral Infection
MicroRNAs (miRNAs) are small noncoding RNA molecules that act as central regulators of gene expression. miRNAs have diverse functions in physiology....