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HOPX is a tumor-suppressive biomarker that corresponds to T cell infiltration in skin cutaneous melanoma
BackgroundSkin cutaneous melanoma (SKCM) is the most threatening type of skin cancer. Approximately 55,000 people lose their lives every year due to...
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Expression of CIB1 correlates with colorectal liver metastases but not with peritoneal carcinomatosis
BackgroundMolecular differences in colorectal cancer (CRC) are associated with the metastatic route. Patient survival is mainly driven by metastatic...
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The “Great Debate” at Immunotherapy Bridge 2022, Naples, November 30th–December 1st, 2022
The 2022 Immunotherapy Bridge congress (November 30–December 1, Naples, Italy) featured a Great Debate session which addressed three contemporary...
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A deep learning quantified stroma-immune score to predict survival of patients with stage II–III colorectal cancer
BackgroundProfound heterogeneity in prognosis has been observed in colorectal cancer (CRC) patients with intermediate levels of disease (stage...
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Automated whole-slide images assessment of immune infiltration in resected non-small-cell lung cancer: towards better risk-stratification
BackgroundHigh immune infiltration is associated with favourable prognosis in patients with non-small-cell lung cancer (NSCLC), but an automated...
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Immune System in Action
Tumor exists as a complex network of structures with an ability to evolve and evade the host immune surveillance mechanism. The immune milieu which...
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Spatial tumour gene signature discriminates neoplastic from non-neoplastic compartments in colon cancer: unravelling predictive biomarkers for relapse
BackgroundOpting for or against the administration of adjuvant chemotherapy in therapeutic management of stage II colon cancer remains challenging....
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The Role of Surgery in Managing Primary and Metastatic Colorectal Cancer
The surgical management of metastatic colorectal cancer (CRC) has evolved dramatically over the last few decades. Proper lymph node evaluation is...
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Nanotechnology and Immunomodulators in Cancer
In the last years, immunotherapy represents a promising strategy for treatment in cancer without massive damaging normal cells, by reprogramming and...
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Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma
The phase 3 ZUMA-7 trial in second-line large B cell lymphoma demonstrated superiority of anti-CD19 CAR T cell therapy (axicabtagene ciloleucel...
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Immunoty** and Quantification of Melanoma Tumor–Infiltrating Lymphocytes
The density of tumour-infiltrating lymphocytes (TILs) in melanoma is correlated with improved clinical prognosis; however, standardized TIL...
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World-Wide Immunoscore Task Force: meeting report from the “Melanoma Bridge”, Napoli, November 30th–December 3rd, 2016
The predictive accuracy of the traditional staging system is based on disease progression as a tumour cell-autonomous process, but it fails to...
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An exploration of immunohistochemistry-based prognostic markers in patients undergoing curative resections for colon cancer
BackgroundThe immune system recognizes and destroys cancer cells. However, cancer cells develop mechanisms to avoid detection by expressing cell...
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Perspectives in immunotherapy: meeting report from the immunotherapy bridge (December 2nd–3rd, 2020, Italy)
Improved understanding of tumor immunology has enabled the development of therapies that harness the immune system and prevent immune escape....
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Prognostic role of tumour-infiltrating lymphocytes and macrophages in relation to MSI, CDX2 and BRAF status: a population-based study of metastatic colorectal cancer patients
BackgroundTumour-infiltrating CD3, CD8 lymphocytes and CD68 macrophages are associated with favourable prognosis in localised colorectal cancer, but...
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A combined spatial score of granzyme B and CD68 surpasses CD8 as an independent prognostic factor in TNM stage II colorectal cancer
BackgroundPrevious assessments of peritumoral inflammatory infiltrate in colorectal cancer (CRC) have focused on the role of CD8 + T lymphocytes. We...
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FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression
BackgroundInvasion and metastasis are the main causes of unfavourable prognosis in patients diagnosed with bladder cancer. The efficacy of...
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Cancer immunotherapy: it’s time to better predict patients’ response
In less than a decade, half a dozen immune checkpoint inhibitors have been approved and are currently revolutionising the treatment of many cancer...
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CXCL9, CXCL10, CXCL11/CXCR3 Axis and Immune Activation
Chemokines are proteins that promote tissue extravasation, immune cell differentiation, and chemotaxis. Their applicability in the oncology is...
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A phase 1/2 trial of an immune-modulatory vaccine against IDO/PD-L1 in combination with nivolumab in metastatic melanoma
Anti-programmed death (PD)-1 (aPD1) therapy is an effective treatment for metastatic melanoma (MM); however, over 50% of patients progress due to...
