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Cultural adaptation and psychometric adequacy of the Persian version of the physical activity scale for the elderly (P-PASE)
ObjectiveThis cross sectional study was conducted to investigate cultural adaption and validation of the Persian version of the PASE among the...
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Body Mass as a Biomarker and Femoral Fracture
Body mass represents a wide range of components, from atoms to tissues or organs. In clinical practice, body composition is generally assessed at the...
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Classification accuracy of blood-based and neurophysiological markers in the differential diagnosis of Alzheimer’s disease and frontotemporal lobar degeneration
BackgroundIn the last decade, non-invasive blood-based and neurophysiological biomarkers have shown great potential for the discrimination of several...
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HoSAGE: sarcopenia in older patient with intermediate / high-risk prostate cancer, prevalence and incidence after androgen deprivation therapy: study protocol for a cohort trial
BackgroundSarcopenia is defined by a loss of muscle strength associated to a decrease in skeletal muscle mass. Ageing greatly contributes to...
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Dynamic reciprocal relationships between cognitive and functional declines along the Alzheimer’s disease continuum in the prospective COGICARE study
BackgroundThoroughly understanding the temporal associations between cognitive and functional dimensions along the dementia process is fundamental to...
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The Effect of Cognitive Intervention on Cognitive Function in Older Adults With Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Cognitive intervention includes cognitive stimulation, cognitive training, and cognitive rehabilitation. This systematic review was performed to...
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Prodromal characteristics of dementia with Lewy bodies: baseline results of the MEMENTO memory clinics nationwide cohort
BackgroundIsolated subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) are the prodromal phases of dementia with Lewy bodies...
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Sex Differences in the Long-Term Consequences of Stroke
Stroke is the fifth leading cause of death and as healthcare intervention improves, the number of stroke survivors has also increased. Furthermore,...
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Extensive frontal focused ultrasound mediated blood–brain barrier opening for the treatment of Alzheimer’s disease: a proof-of-concept study
BackgroundFocused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening has shown efficacy in removal of amyloid plaque and improvement of...
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Research and application advances in rehabilitation assessment of stroke
Stroke has a high incidence and disability rate, and rehabilitation is an effective means to reduce the disability rate of patients. To systematize...
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Measuring instrumental activities of daily living in non-demented elderly: a comparison of the new performance-based Harvard Automated Phone Task with other functional assessments
BackgroundImpairment in instrumental activities of daily living (IADL) may occur in the earliest stages of mild cognitive impairment (MCI). However,...
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The Promise of Niacin in Neurology
Niacin (vitamin B3) is an essential nutrient that treats pellagra, and prior to the advent of statins, niacin was commonly used to counter...
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The distinct disrupted plasticity in structural and functional network in mild stroke with basal ganglia region infarcts
Stroke induced by basal ganglia infarction often impair cognitive function. The exploration of topological patterns in structural and functional...
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Rationale and study design of a randomized, placebo-controlled, double-blind phase 2b trial to evaluate efficacy, safety, and tolerability of an oral glutaminyl cyclase inhibitor varoglutamstat (PQ912) in study participants with MCI and mild AD—VIVIAD
BackgroundVaroglutamstat (formerly PQ912) is a small molecule that inhibits the activity of the glutaminyl cyclase to reduce the level of...
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The impact of physical disability on the risk of gastric cancer incidence in elderly patients with diabetes: a focus on regional disparity
PurposeElderly patients with type 2 diabetes mellitus (T2DM) may have a higher risk of physical disability. This study investigated the incidence of...
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The circadian rhythm of arterial blood pressure in Alzheimer’s disease and vascular dementia
Hypertension is considered a risk factor for stroke and dementia. Ambulatory blood pressure monitoring (ABPM) is a useful tool in the diagnosis and...
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Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer’s disease
BackgroundA decline in instrumental activities of daily living (IADL) correlates with the progression from mild cognitive impairment (MCI) to...
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Comprehensive Management of Daily Living Activities, behavioral and Psychological Symptoms, and Cognitive Function in Patients with Alzheimer's Disease: A Chinese Consensus on the Comprehensive Management of Alzheimer's Disease
Alzheimer's disease (AD) is the most common cognitive disorder in the elderly. Its main clinical manifestations are cognitive decline (C), behavioral...
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Multi-omics integrative modelling for stereotactic body radiotherapy in early-stage non-small cell lung cancer: clinical trial protocol of the MONDRIAN study
BackgroundCurrently, main treatment strategies for early-stage non-small cell lung cancer (ES-NSCLC) disease are surgery or stereotactic body...
