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Venetoclax-based chemotherapy in acute and chronic myeloid neoplasms: literature survey and practice points
Venetoclax (VEN), a small-molecule inhibitor of B cell leukemia/lymphoma-2, is now FDA approved (November 2018) for use in acute myeloid leukemia...
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Clinical-biological characteristics and treatment outcomes of pediatric pro-B ALL patients enrolled in BCH-2003 and CCLG-2008 protocol: a study of 121 Chinese children
BackgroundAlthough leukemic blast cells of Pro-B cell acute lymphoblastic leukemia (ALL) are arrested at the same stage of B cell differentiation,...
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Association between serum amyloid A levels and coronary heart disease: a systematic review and meta-analysis of 26 studies
Background and aimsThe relationship between serum amyloid A (SAA) and coronary heart disease (CHD) remains inconsistent, and the correlation of SAA...
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The use of PanDrugs to prioritize anticancer drug treatments in a case of T-ALL based on individual genomic data
BackgroundAcute T-cell lymphoblastic leukaemia (T-ALL) is an aggressive disorder derived from immature thymocytes. The variability observed in...
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Cord blood procalcitonin level and early-onset sepsis in extremely preterm infants
Early-onset neonatal sepsis (EOS) is observed in 1.7% of extremely preterm infants, with high morbidity and mortality rate. Cord blood procalcitonin...
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New attempts for central nervous infiltration of pediatric acute lymphoblastic leukemia
The cure rate of acute lymphoblastic leukemia (ALL), the commonest childhood cancer, has been sharply improved and reached almost 90% ever since the...
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Involvement of the central nervous system in acute lymphoblastic leukemia: opinions on molecular mechanisms and clinical implications based on recent data
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. One of the major clinical challenges is adequate diagnosis and treatment of...
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Inotuzumab ozogamicin is effective in relapsed/refractory extramedullary B acute lymphoblastic leukemia
BackgroundExtramedullary involvement of B-cell Acute Lymphoblastic Leukemia (EM-ALL) is a rare occurrence, characterized by dismal outcome and the...
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A rare case report of heavy dose colchicine induced acute kidney injury
BackgroundColchicine is a natural alkaloid that is mainly used for the treatment of inflammatory diseases. Effective and toxic doses are very...
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Ponatinib induces a sustained deep molecular response in a chronic myeloid leukaemia patient with an early relapse with a T315I mutation following allogeneic hematopoietic stem cell transplantation: a case report
BackgroundAtypical BCR-ABL1 transcripts are detected in less than 5% of patients diagnosed with chronic myeloid leukaemia (CML), of which e19a2 is...
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Variable spectrum of disease and risk factors of peripartum Clostridium difficile infection: report of 14 cases from French hospitals and literature review
Our aim was to study Clostridium difficile infection (CDI) in peripartum women in France and compare them to cases published in the literature. We...
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PRognostic factor of Early Death In phase II Trials or the end of ‘sufficient life expectancy’ as an inclusion criterion? (PREDIT model)
BackgroundOptimizing patient selection is a necessary step to design better clinical trials. ‘Life expectancy’ is a frequent inclusion criterion in...
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Concordance between glucose-6-phosphate dehydrogenase (G6PD) genotype and phenotype and rasburicase use in patients with hematologic malignancies
Phenotypic rather than genotypic tests remain the gold standard for diagnosing glucose-6-phosphate dehydrogenase (G6PD) deficiency. However, with...
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Neutrophils in critical illness
During critical illness, dramatic alterations in neutrophil biology are observed including abnormalities of granulopoeisis and lifespan, cell...
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Role of cytarabine in paediatric acute promyelocytic leukemia treated with the combination of all-trans retinoic acid and arsenic trioxide: a randomized controlled trial
BackgroundThe combination of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) has been suggested to be safe and effective for adult acute...
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Acute myeloid leukemia and pregnancy: clinical experience from a single center and a review of the literature
BackgroundAcute myeloid leukemia (AML) accounts for more than two thirds of leukemia during pregnancy and has an incidence of 1 in 75,000 to 100,000....
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The clonal evolution of two distinct T315I-positive BCR-ABL1 subclones in a Philadelphia-positive acute lymphoblastic leukemia failing multiple lines of therapy: a case report
BackgroundThe treatment of Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL) patients who harbor the T315I BCR-ABL1 mutation or...
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Immunostimulants in Cancer Therapy
During the past few decades, immunotherapy has become a clinical reality, and an ever-increasing number of cancer patients are receiving immunologic...
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Inhibitors of the JAK/STAT Pathway, with a Focus on Ruxolitinib and Similar Agents
Substantive advances in our understanding of the pathogenesis of different types of lymphoma have arisen with the advent of methodologies to...