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Characterization of genomic DNA sequence of the candidate gene for FB_Mfu10 associated with fire blight resistance in Malus species
ObjectiveThe proposed candidate gene underlying the Malus fusca fire blight resistance locus on chromosome 10 was previously predicted to possess...
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A framework for the evaluation and reporting of incidental findings in clinical genomic testing
Currently, there are no widely accepted recommendations in the genomics field guiding the return of incidental findings (IFs), defined here as...
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Recombination drives the emergence of orf virus diversity: evidence from the first complete genome sequence of an Indian orf virus isolate and comparative genomic analysis
Contagious pustular dermatitis is a disease that primarily infects small ruminants and possesses zoonotic potential. It is caused by orf virus...
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Preparation of NanoMEDIC Extracellular Vesicles to Deliver CRISPR-Cas9 Ribonucleoproteins for Genomic Exon Skip**
The CRISPR-Cas9 system has quickly become the standard tool for genome editing. To deliver this system to target cells, adeno-associated virus (AAV)...
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Whole genome sequence of Citrus yellow vein clearing virus CA1 isolate
ObjectivesCitrus yellow vein clearing virus (CYVCV) is an emerging disease that poses a significant threat to the citrus industry in California. In...
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Constant ratio between the genomic components of bipartite begomoviruses during infection and transmission
The genomic components of multipartite viruses are encapsidated in separate virus particles, and the frequencies of genomic components represent one...
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Taxonomic Classification of Geminiviruses Based on Pairwise Sequence Comparisons
Geminiviridae is the largest and one of the most diverse families of plant viruses, comprising 14 genera demarcated based on host range, type of...
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The hospital Israelita Albert Einstein standards for constitutional sequence variants classification: version 2023
BackgroundNext-generation sequencing has had a significant impact on genetic disease diagnosis, but the interpretation of the vast amount of genomic...
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Urothelial Bladder Cancer: Genomic Alterations in Fibroblast Growth Factor Receptor
Background and ObjectiveGenomic alterations in fibroblast growth factor receptor ( FGFR) genes have been linked to a reduced response to immune...
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Genomic instability evaluation in different cell line by random amplified polymorphic DNA-PCR analysis
The cause of cancer is disorders and unstable genome. Some factors affect proper functioning of the DNA. These situations lead to cell death, cancer,...
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Australian public perspectives on genomic data governance: responsibility, regulation, and logistical considerations
Genomic sequencing generates huge volumes of data, which may be collected or donated to form large genomic databases. Such information can be stored...
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Cytogenetics investigation in 151 Brazilian infertile male patients and genomic analysis in selected cases: experience of 14 years in a public genetic service
ObjectivesMale infertility accounts for approximately 30% of cases of reproductive failure. The characterization of genetic variants using...
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DsRNA sequencing revealed a previously missed terminal sequence of a +ssRNA virus that infects dinoflagellate Heterocapsa circularisquama
Heterocapsa circularisquama RNA virus (HcRNAV) is the only dinoflagellate-infecting RNA virus cultured. However, only two strains of HcRNAV have been...
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Genomic profiling of small bowel adenocarcinoma: a pooled analysis from 3 databases
BackgroundSmall bowel adenocarcinoma is a rare disease. The genomic profiling tumours according to clinical characteristics and its impact on the...
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Genomic Microsatellite Mining and Characteristic Analysis of Gobiidae Fish
AbstractMicrosatellites or single sequence repeats (SSRs) are widespread in the genome of eukaryotes and prokaryotes, and are usually used for...
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Otus scops adenovirus: the complete genome sequence of a novel aviadenovirus discovered in a wild owl
We present the complete genome sequence of an aviadenovirus obtained by metagenomics from cloacal swabs taken from a free-living Eurasian scops owl ( O...
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Complete nucleotide sequence of hackberry virus A, a tentative member of the genus Waikavirus
The complete genomic sequence of a waikavirus from Chinese hackberry in Zhejiang province, China, named “hackberry virus A” (HVA), was determined...
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Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries
We develop a method, SBayesRC, that integrates genome-wide association study (GWAS) summary statistics with functional genomic annotations to improve...
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Genomic analysis reveals HDAC1 regulates clinically relevant transcriptional programs in Pancreatic cancer
Novel strategies are needed to combat multidrug resistance in pancreatic ductal adenocarcinoma (PDAC). We applied genomic approaches to understand...
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DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions
Genomic imprinting is regulated by parental-specific DNA methylation of imprinting control regions (ICRs). Despite an identical DNA sequence, ICRs...
