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Lobular Carcinoma of the Breast: Spectrum of Imaging Findings and New Emerging Technologies on the Horizon
Invasive lobular carcinoma (ILC) is the second most common histologic form of breast cancer, representing 5% to 15% of all invasive breast cancers....
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Diagnostic value of applying preoperative breast ultrasound and clinicopathologic features to predict axillary lymph node burden in early invasive breast cancer: a study of 1247 patients
BackgroundSince the Z0011 trial, the assessment of axillary lymph node status has been redirected from the previous assessment of the occurrence of...
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Addressing Breast Cancer Disparities in Advancements for Conquering Drug Resistance
Breast cancer is a global concern with high morbidity and mortality rates. While incidence rates remain high in developed countries compared to...
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Mammographic breast density and survival in women with invasive breast cancer
PurposeWe explored the under-debate association between mammographic breast density (MBD) and survival.
MethodsFrom the Piedmont Cancer Registry, we...
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Reduced representative methylome profiling of cell-free DNA for breast cancer detection
BackgroundWhole-genome methylation sequencing of cfDNA is not cost-effective for tumor detection. Here, we introduce reduced representative methylome...
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Hereditary Lobular Breast Cancer Syndrome: Role of Surgery
Hereditary lobular breast cancer is a novel and rare inherited syndrome, and it represents a multifaceted and fascinating clinical entity. In recent...
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High-dose alkylating chemotherapy in BRCA-altered triple-negative breast cancer: the randomized phase III NeoTN trial
Exploratory analyses of high-dose alkylating chemotherapy trials have suggested that BRCA1 or BRCA2-pathway altered (BRCA-altered) breast cancer...
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Current regular aspirin use and mammographic breast density: a cross-sectional analysis considering concurrent statin and metformin use
PurposeThe nonsteroidal anti-inflammatory drug aspirin is an agent of interest for breast cancer prevention. However, it is unclear if aspirin...
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Deep learning of mammogram images to reduce unnecessary breast biopsies: a preliminary study
BackgroundPatients with a Breast Imaging Reporting and Data System (BI-RADS) 4 mammogram are currently recommended for biopsy. However, 70–80% of the...
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Neoadjuvant durvalumab plus weekly nab-paclitaxel and dose-dense doxorubicin/cyclophosphamide in triple-negative breast cancer
The goal of this Phase I/II trial is to assess the safety and efficacy of administering durvalumab concurrent with weekly nab-paclitaxel and...
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Hereditary Breast Cancer Non-CDH1 Associated
Although breast cancer (BC) mainly arises as a sporadic tumor, between 7 and 10% of BC patients present a pathogenic variant (PV) of selected genes....
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AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial
Screening mammography reduces breast cancer mortality, but studies analyzing interval cancers diagnosed after negative screens have shown that many...
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Hormone and receptor activator of NF-κB (RANK) pathway gene expression in plasma and mammographic breast density in postmenopausal women
BackgroundHormones impact breast tissue proliferation. Studies investigating the associations of circulating hormone levels with mammographic breast...
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HERVK-mediated regulation of neighboring genes: implications for breast cancer prognosis
Human endogenous retroviruses (HERVs) are the remnants of ancient retroviral infections integrated into the human genome. Although most HERVs are...
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Dose-dense sequential adjuvant chemotherapy in the trastuzumab era: final long-term results of the Hellenic Cooperative Oncology Group Phase III HE10/05 Trial
BackgroundDose-dense sequential chemotherapy with anthracyclines and taxanes achieved an 18% reduction of recurrence risk in early breast cancer...
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Supplemental breast cancer-screening ultrasonography in women with dense breasts: a systematic review and meta-analysis
BackgroundMammography is not effective in detecting breast cancer in dense breasts.
MethodsA search in Medline, Cochrane, EMBASE and Google Scholar...
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Associations amongst genes, molecules, cells, and organs in breast cancer metastasis
This paper is a cross fertilization of ideas about the importance of molecular aspects of breast cancer metastasis by basic scientists, a...
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Toxoplasma gondii suppresses proliferation and migration of breast cancer cells by regulating their transcriptome
BackgroundBreast cancer is the most common cancer in women worldwide. Toxoplasma gondii ( T. gondii ) has shown anticancer activity in breast cancer...
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Associations of alcohol consumption with breast tissue composition
BackgroundWe investigated the associations of alcohol with percentage of epithelium, stroma, fibroglandular tissue (epithelium + stroma), and fat in...
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Trends in chemotherapy use for early-stage breast cancer from 2006 to 2019
BackgroundLittle is known about how use of chemotherapy has evolved in breast cancer patients. We therefore describe chemotherapy patterns for women...
