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Bioinformatical View on the Contribution of MAST/IRE-Dependent Phosphorylation in the Tubulin Code
AbstractProtein kinases represent one of the largest eukaryotic enzyme superfamilies. However, only a few can directly phosphorylate tubulin and...
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Dynamics of the Spindle Assembly Checkpoint
The spindle assembly checkpoint (SAC) normally acts to prevent cells that have not fully completed separation of their replicated chromosomes from...
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Cell Migration in the Mammalian Cortex
One of the hallmarks of the develo** central nervous system (CNS) is the migration of diverse newly born cells from embryonic germinal regions to...
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Cell Migration in the Mammalian Cortex
One of the hallmarks of the develo** central nervous system (CNS) is the migration of diverse newly born cells from embryonic germinal regions to...
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Exploring the phospho-landscape of NEK6 kinase: systematic annotation of phosphosites and their implications as biomarkers in carcinogenesis
NIMA-related kinase 6 (NEK6) is a serine/threonine protein kinase known for its ability to promote cell progression and is a promising therapeutic...
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NEK7: a new target for the treatment of multiple tumors and chronic inflammatory diseases
NIMA-related kinase 7 (NEK7) is a serine/threonine kinase, which is the smallest one in mammalian NEK family. At present, many studies have reported...
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Radiotherapy modulates tumor cell fate decisions: a review
Cancer has always been a worldwide problem, and the application of radiotherapy has greatly improved the survival rate of cancer patients....
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Genetics of human brain development
Brain development in humans is achieved through precise spatiotemporal genetic control, the mechanisms of which remain largely elusive. Recently,...
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Potassium Channel KCNH1 Activating Variants Cause Altered Functional and Morphological Ciliogenesis
The primary cilium is a non-motile sensory organelle that extends from the surface of most vertebrate cells and transduces signals regulating...
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STIL/AURKA axis promotes cell proliferation by influencing primary cilia formation in bladder cancer
BackgroundThe primary cilia (PC) is a microtubule-based and nonmotile organelle which protrudes from the surface of almost all mammalian cells. At...
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GADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis
GADD45 is a gene family consisting of GADD45A, GADD45B, and GADD45G that is often induced by DNA damage and other stress signals associated with...
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Mitotic protein kinase-driven crosstalk of machineries for mitosis and metastasis
Accumulating evidence indicates that mitotic protein kinases are involved in metastatic migration as well as tumorigenesis. Protein kinases and...
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Evidence for the role of Rab11-positive recycling endosomes as intermediates in coronavirus egress from epithelial cells
After their assembly by budding into the lumen of the intermediate compartment (IC) at the endoplasmic reticulum (ER)–Golgi interface, coronaviruses...
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PAX2 mediated upregulation of ESPL1 contributes to cisplatin resistance in bladder cancer through activating the JAK2/STAT3 pathway
Extra spindle-polar body like 1 (ESPL1) is associated with the development of a variety of cancers, including bladder cancer, and is closely related...
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Analysis of the Adherent Cell Response to the Substrate Stiffness Using Tensegrity
Cell’s shape is dependent on the cytoskeleton mechanical properties. Hybrid models were developed that combine the discrete structure for the...
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The complexity of human papilloma virus in cancers: a narrative review
Among human tumorigenic viruses, the role of Human papillomavirus (HPV) has been proven as one of the most important oncoviruses that are associated...
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Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty
Developmental abnormalities of the gonadotropin-releasing hormone (GnRH) neuronal network result in a range of conditions from idiopathic...
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Epithelial–Mesenchymal Transition and Cancer Stem Cells
Epithelial–mesenchymal transition (EMT), a cellular phenotypic change from epithelial to mesenchymal-like features, is related to the resistance and...