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Deterioration in saliva quality in patients with Sjögren’s syndrome: impact of decrease in salivary epidermal growth factor on the severity of intraoral manifestations
BackgroundSjögren’s syndrome (SS) is a chronic inflammatory autoimmune disease characterized by lymphocytic infiltration of the exocrine glands,...
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Molecular Mechanisms and Therapeutics for Spinocerebellar Ataxia Type 2
The effective therapeutic treatment and the disease-modifying therapy for spinocerebellar ataxia type 2 (SCA2) (a progressive hereditary disease...
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Neural Regulation of Inflammation: Pharmacological Mechanisms and Therapeutic Perspectives
During the past three decades, our knowledge about the close relationship and functional integration between the immune system and the nervous system...
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Anticholinergic Syndrome
The anticholinergic syndrome is common and may result from exposures to many drugs or natural substances (Table 1). Anticholinergic effects are...
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An evaluation of the prevalence of potentially inappropriate medications in older people with cognitive impairment living in Northern Sweden using the EU(7)-PIM list
PurposeAs people get older, their sensitivity to drugs and adverse drug reactions can increase due to pharmacokinetic and pharmacodynamic changes....
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Antiparkinsonian Agents
Parkinson disease, named after James Parkinson who first described the disorder in 1817, is a chronic, progressive neurologic disorder clinically...
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Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directions
Imidazole and benzimidazole rings are the most important nitrogen-containing heterocycles, which are widely explored and utilized by the...
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Heteroreceptor Complexes Implicated in Parkinson’s Disease
Heteromerization alters GPCR recognition, G-protein activation, receptor signaling and trafficking, thus changing receptor protomer pharmacology and...
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Anticholingergic Syndrome
The anticholinergic syndrome is common and may result from exposures to many drugs or natural substances (Table 1). Anticholinergic effects are...
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Age and the Process of Aging
The epidemiological transition, with a rapid increase of the proportion of the global population aged over 65 years from 11 % in 2010 to 22 % in 2050...
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The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia
While the specific trigger of Parkinson Disease (PD) in most patients is unknown, considerable evidence suggests that the neuroinflammatory response...
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Prescription rate of medications potentially contributing to lower urinary tract symptoms and detection of adverse reactions by prescription sequence symmetry analysis
BackgroundThe lower urinary tract symptoms (LUTS) increases with age and can have a significant effect on the quality of life of the patients....
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Anti-Parkinson Activity
A fundamental lesion in Parkinson’s disease is a marked deficiency in the dopaminergic innervation of the basal ganglia owing to degeneration of...
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Synthesis, Structural, DNA Binding and Cleavage Studies of Cu(II) Complexes Containing Benzothiazole Cored Schiff Bases
Novel benzothiazole Schiff bases L 1 [1-((4,6-difluorobenzo[d]thiazol-2-ylimino)methyl) naphthalen-2-ol], L 2 ...
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Managing Drug Therapy of Older Patients in Primary and Secondary Care
The progressive aging of the European population faces us with a new challenge for healthcare, secondary to the increasing prevalence of chronic...
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Protein-structure-guided discovery of functional mutations across 19 cancer types
Local concentrations of mutations are well known in human cancers. However, their three-dimensional spatial relationships in the encoded protein have...
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Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine
Multidrug and toxin extrusion (MATE; SLC47A) proteins are membrane transporters mediating the excretion of organic cations and zwitterions into bile...
