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Chidamide increases the sensitivity of refractory or relapsed acute myeloid leukemia cells to anthracyclines via regulation of the HDAC3 -AKT-P21-CDK2 signaling pathway
BackgroundInduction therapy for acute myeloid leukemia (AML) is an anthracycline-based chemotherapy regimen. However, many patients experience a...
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Elastin-derived peptides (EDPs) as a potential pro-malignancy factor in human leukemia cell lines
AbstractThe extracellular matrix (ECM) is currently considered to be an important factor influencing the migration and progression of cancer cells....
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p53 biology and reactivation for improved therapy in MDS and AML
Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) originate from preleukemic hematopoietic conditions, such as clonal hematopoiesis of...
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Philadelphia chromosome positive chronic myeloid leukemia with 5q deletion at diagnosis
BackgroundAlthough, molecular genetic analyses became more and more important to guide therapy decisions in leukemia, banding cytogenetic analysis...
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Hesperidin/Salinomycin Combination; a Natural Product for Deactivation of the PI3K/Akt Signaling Pathway and Anti-Apoptotic Factors in KG1a Cells
AML is a highly aggressive malignant clonal disease of hematopoietic origin. Hesperidin as a polyphenol glycoside, Activates the apoptotic pathway...
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Insights into the prenatal origin of childhood acute lymphoblastic leukemia
Pediatric acute lymphoblastic leukemia (ALL) is defined by recurrent chromosomal aberrations including hyperdiploidy and chromosomal translocations....
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Sirtuin 1 inhibits lipopolysaccharide-induced inflammation in chronic myelogenous leukemia k562 cells through interacting with the Toll-like receptor 4-nuclear factor κ B-reactive oxygen species signaling axis
BackgroundChronic myelogenous leukemia (CML) is a clonal myeloproliferative neoplasm resulting from BCR–ABL-transformed hematopoietic stem cells....
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Leukocyte subtype classification with multi-model fusion
Accurate classification of leukocytes is crucial for the diagnosis of hematologic malignancies, particularly leukemia. However, traditional leukocyte...
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Coexistence of recurrent chromosomal abnormalities and the Philadelphia chromosome in acute and chronic myeloid leukemias: report of five cases and review of literature
Progression of chronic myelogenous leukemia (CML) is frequently accompanied by cytogenetic evolution. Additional genetic abnormalities are seen in...
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Zebrafish as a Novel Pharmacological Screening Model for Drug Discovery and Development Against Hematological Disorders
Zebrafish is a novel pharmacological screening model for increasing the pace of drug discovery and development. It is an extensively used vertebrate...
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HLA alleles, haplotypes frequencies, and their association with hematological disorders: a report from 1550 families whose patients underwent allogeneic bone marrow transplantation in Egypt
HLA alleles are representative of ethnicities and may play important roles in predisposition to hematological disorders. We analyzed DNA samples for...
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Genomic and epigenomic predictors of response to guadecitabine in relapsed/refractory acute myelogenous leukemia
BackgroundGuadecitabine is a novel DNA methyltransferase (DNMT) inhibitor with improved pharmacokinetics and clinical activity in a subset of...
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A Crosstalk on Codon Usage in Genes Associated with Leukemia
Leukemia is the outcome of aggregation of damaged white blood cells. Several genes were reported to be associated with the pathogenesis of leukemia....
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Genomic trajectory in leukemogenesis of myeloproliferative neoplasms: a case report
BackgroundWe report a patient with Essential Thrombocythemia (ET), subsequently diagnosed with concurrent myeloid and lymphoid leukemia. Generally,...
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The incidence, genetic characteristics, and prognosis of leukemia with concurrent pathogenic fusion genes: a series of 25 cases from a large cohort of leukemia patients
Recurrent fusion genes (FGs) with clinical significances in leukemias are mainly mutually exclusive, and the coexistence of different FGs has been...
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Water and Electrolytes Disorders in Oncology
Introduction: water and electrolyte disorders are frequently found in oncologic patients since they are usually exposed to diverse symptoms,...
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The effects of photodynamic therapy on leukemia cells mediated by KillerRed, a genetically encoded fluorescent protein photosensitizer
BackgroundLeukemia is a cancer of blood and bone marrow cells, causing about 300,000 deaths worldwide. Photodynamic therapy (PDT) is a promising...
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Bioactivities and the structural modification of Parthenolide: a review
Parthenolide, a sesquiterpene lactone derived from Feverfew (Tanacetum parthenium) buds, has attracted significant attention due to its versatile...
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Immunotherapy for Hematological Cancers
Treatment of hematological cancers has evolved over the years for these deadly blood disorders. The treatment strategy for these disorders has...
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Colocalization of BCR Protein with Clathrin, Actin, and Cortactin Suggests Its Possible Role in the Regulation of Actin Branching and Clathrin-Mediated Endocytosis
AbstractThe Philadelphia chromosome is a result of reciprocal translocation between chromosomes 9 and 22 and serves as a distinct marker of several...
