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Upregulation of acid sensing ion channel 1a (ASIC1a) by hydrogen peroxide through the JNK pathway
Oxidative stress is intimately tied to neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis, and acute...
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Exercise pressor responses are exaggerated relative to force production during, but not following, thirty-minutes of rhythmic handgrip exercise
PurposeThis study tested the hypothesis that blood pressure responses would increase relative to force production in response to prolonged bouts of...
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TDAG8 deficiency reduces satellite glial number and pro-inflammatory macrophage number to relieve rheumatoid arthritis disease severity and chronic pain
BackgroundThe autoimmune disease rheumatoid arthritis (RA) affects approximately 1% of the global population. RA is characterized with chronic joint...
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Role of ASIC1a in Normal and Pathological Synaptic Plasticity
Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are broadly distributed in the mammalian nervous...
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Molecular Mechanisms of Metastasis to the Bone
Bone metastasis is an incurable and lethal aspect of many advanced-stage malignancies that significantly impacts patient quality of life. Although it...
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Different Peas in the Same Pod: The Histaminergic Neuronal Heterogeneity
The histaminergic neuronal system is recently receiving increasing attention, as much has been learned over the past 25 years about histamine role as...
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P2X3-Containing Receptors as Targets for the Treatment of Chronic Pain
Current therapies for the treatment of chronic pain provide inadequate relief for millions of suffering patients, demonstrating the need for better...
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Single-Unit Electrophysiological Recordings of Primary Muscle Sensory Neurons Using a Novel Ex Vivo Preparation
For decades, multiple electrophysiological techniques have been used to characterize the responses of primary afferents to a variety of stimuli under...
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Roles of ASICs in Nociception and Proprioception
Acid-sensing ion channels (ASICs) are a group of proton-gated ion channels belonging to the degenerin/epithelial sodium channel (DED/ENaC) family....
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Bicarbonate secretion and acid/base sensing by the intestine
The transport of bicarbonate across the enterocyte cell membrane regulates the intracellular as well as the luminal pH and is an essential part of...
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Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion
BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is one of the most prevalent monogenic human diseases. It is mostly caused by...
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Research focus and thematic trends of transient receptor potential vanilloid member 1 research: a bibliometric analysis of the global publications (1990–2023)
Recently, various studies have been devoted to the study of transient receptor potential vanilloid member 1 (TRPV1)-related diseases, potential...
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The Somatosensory World of the African Naked Mole-Rat
The naked mole-rat (Heterocephalus glaber) is famous for its longevity and unusual physiology. This eusocial species that lives in highly ordered and...
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Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS
The cerebrospinal fluid (CSF) is a complex solution that circulates around the CNS, and whose composition changes as a function of an animal’s...
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Alteration and dysfunction of ion channels/transporters in a hypoxic microenvironment results in the development and progression of gastric cancer
BackgroundGastric cancer (GC) is one of the most common malignant cancers in the world and has only few treatment options and, concomitantly, a poor...
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Molecular profile of metastasis, cell plasticity and EMT in pancreatic cancer: a pre-clinical connection to aggressiveness and drug resistance
The metastasis is a multistep process in which a small proportion of cancer cells are detached from the colony to enter into blood cells for...
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Epithelial-mesenchymal transition process during embryo implantation
The epithelial to mesenchymal transition (EMT) in endometrial epithelial and trophectoderm cells is essential for the progression of embryo...
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Licorice extract inhibits growth of non-small cell lung cancer by down-regulating CDK4-Cyclin D1 complex and increasing CD8+ T cell infiltration
BackgroundTargeting tumor microenvironment (TME) may provide therapeutic activity and selectivity in treating cancers. Therefore, an improved...
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Physiological relevance of proton-activated GPCRs
The detection of H + concentration variations in the extracellular milieu is accomplished by a series of specialized and non-specialized pH-sensing...
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Ion Channel Pharmacology for Pain Modulation
A large series of different ion channels have been identified and investigated as potential targets for new medicines for the treatment of a variety...