Search
Search Results
-
FLAG-KRAS4B as a Model System for KRAS4B Proteoform and PTM Evaluation by Mass Spectrometry
Prior analysis of intact and modified protein forms (proteoforms) of KRAS4B isolated from cell lines and tumor samples by top-down mass spectrometry...
-
Spatially resolved visualization of reprogrammed metabolism in hepatocellular carcinoma by mass spectrometry imaging
BackgroundMetabolic reprogramming refers to tumor-associated metabolic alterations during tumorigenesis and has been regarded as one of the most...
-
Biomarker Identification in Liver Cancers Using Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) Imaging: An Approach for Spatially Resolved Metabolomics
Liver cancers are characterized by interindividual and intratumoral heterogeneity, which makes early diagnosis and the development of therapies...
-
Salivary Proteomic Analysis of Canine Oral Melanoma by MALDI-TOF Mass Spectrometry and LC-Mass Spectrometry/Mass Spectrometry
Canine oral melanoma (COM) is a common oral cancer with aggressiveness and high metastasis. A tumor in a dog’s mouth makes it difficult to be...
-
Detection of SARS-CoV-2 by Mass Spectrometry
Amplification of viral ribonucleic acid by real-time reverse transcriptase polymerase chain reaction is the gold standard to detect severe acute...
-
Standardization of a Mass Spectrometry-Based Workflow for Food Allergen Quantification
In this chapter, the analytical workflow typically used for the development and validation of an analytical method tailored to food allergen...
-
Mass Spectrometry-Based Proteomics Analysis Unveils PTPRS Inhibits Proliferation and Inflammatory Response of Keratinocytes in Psoriasis
In this study, we used data-independent acquisition-mass spectrometry (DIA-MS) to analyze the serum proteome in psoriasis vulgaris (PsO). The serum...
-
Mass spectrometry imaging in gynecological cancers: the best is yet to come
Mass spectrometry imaging (MSI) enables obtaining multidimensional results simultaneously in a single run, including regiospecificity and m/z values...
-
A Spike-Control Approach that Evaluates High Resolution Mass Spectrometry-Based Sequence Variant Analytical Method Performance for Therapeutic Proteins
An amino acid sequence variant (SV) is defined as an unintended amino acid substitution in protein drug products. SVs contribute to product...
-
Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS)
Nicotinamide adenine dinucleotide (NAD + ) is an essential metabolite for fundamental biological phenomena, including aging. Nicotinamide...
-
Mass spectrometry imaging: new eyes on natural products for drug research and development
Natural products (NPs) and their structural analogs represent a major source of novel drug development for disease prevention and treatment. The...
-
Elucidating hippocampal proteome dynamics in moderate hepatic encephalopathy rats: insights from high-resolution mass spectrometry
Hepatic encephalopathy (HE) is a debilitating neurological disorder associated with liver failure and characterized by impaired brain function....
-
Agreement Between a Colorimetric Assay and Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Quantifying Paracetamol Plasma Concentrations
Special populations, like geriatric patients, experience altered paracetamol pharmacokinetics (PK), complicating pain management. More PK research is...
-
Identification of Circulating Biomarkers of COVID-19 Using MALDI-TOF Mass Spectrometry
Matrix-assisted laser desorption/ionization source coupled with time-of-flight mass analyzer mass spectrometry (MALDI-TOF MS) is being widely used to...
-
Implications and prognostic impact of mass spectrometry in patients with newly-diagnosed multiple myeloma
Mass spectrometry (MS) is a promising tool for monitoring monoclonal protein in plasma cell dyscrasias. We included 480 transplant-eligible...
-
Breaking the Mucin Barrier: A New Affinity Chromatography-Mass Spectrometry Approach to Unveil Potential Cell Markers and Pathways Altered in Pseudomyxoma Peritonei
BackgroundPseudomyxoma peritonei (PMP) is a rare peritoneal mucinous carcinomatosis with largely unknown underlying molecular mechanisms....
-
Analysis of Carbohydrates by Mass Spectrometry
Mass spectrometry has become the favorite technique for glycomics analysis. This chapter describes the different ionization methods and provides...
-
Automated Multidimensional Nanoscale Chromatography for Ultrasensitive Targeted Mass Spectrometry
Recent advances in nanoscale separations and high-resolution mass spectrometry permit highly sensitive and accurate analyses of complex protein...
-
High-Resolution Imaging Mass Spectrometry of Human Donor Eye: Photoreceptors Cells and Basal Laminar Deposit of Age-Related Macular Degeneration
Pathologies of the retina are clinically visualized in vivo with OCT and ex vivo with immunohistochemistry. Although both techniques provide valuable...
-
Assessment of an exhaled breath test using ultraviolet photoionization time-of-flight mass spectrometry for the monitoring of kidney transplant recipients
Continuous monitoring for immunosuppressive status, infection and complications are a must for kidney transplantation (KTx) recipients. Traditional...
