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Exploring the Potential of Mesoporous Silica as a Carrier for Puerarin: Characterization, Physical Stability, and In Vivo Pharmacokinetics
The aim of this study was to evaluate the use of a novel porous silica carrier, AEROPERL ® 300 Pharma (AP), to improve the in vitro release and oral...
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Puerarin
Puerarin is an isoflavone component extracted from Pueraria lobata (Willd.) Ohwi and has widely protecting functions on the cardiovascular system,...
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Glycosides from Natural Sources in the Treatment of Diabetes Mellitus
Diabetes is one of the principal causes of death in developed and develo** countries. Many synthetic drugs are being used for the treatment of...
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Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling
Cancer cell plasticity plays a crucial role in tumor initiation, progression, and metastasis and is implicated in the multiple cancer defense...
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Absolute oral bioavailability and disposition kinetics of puerarin in female rats
BackgroundPueraria candollei var . mirifica is a medicinal plant that is promoted as a “Champion Product” by the Government of Thailand. This plant...
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Three-Dimensional (3D)–Printed Zero-Order Released Platform: a Novel Method of Personalized Dosage Form Design and Manufacturing
In 2017, there are 451 million people with diabetes worldwide. These figures were expected to increase to 693 million by 2045. The research and...
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Phospholipid Complex Formulation Technology for Improved Drug Delivery in Oncological Settings: a Comprehensive Review
Addressing poor solubility and permeability issues associated with synthetic drugs and naturally occurring active compounds is crucial for improving...
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Potential regulatory role of PGC-1α within the skeletal muscle during metabolic adaptations in response to high-fat diet feeding in animal models
High-fat diet (HFD) feeding in rodents has become an essential tool to critically analyze and study the pathological effects of obesity, including...
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Interactions Between Antidepressants and Intestinal Microbiota
The microbiota-gut-brain axis has been shown to influence human health and diseases, including depression. The interactions between drugs and...
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Monomeric compounds from natural products for the treatment of pulmonary fibrosis: a review
Pulmonary fibrosis (PF) is the end stage of lung injury and chronic lung diseases that results in diminished lung function, respiratory failure, and...
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Targeting ferroptosis by natural products in pathophysiological conditions
Ferroptosis is a form of cell death that is induced by iron-mediated accumulation of lipid peroxidation. The involvement of ferroptosis in different...
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The Combination of Zhuli Decoction and N-butylphthalide Inhibits Cell Apoptosis Induced by CO Poisoning through the PI3K/AKT/GSK-3β Signaling Pathway
Carbon monoxide poisoning (COP) represents a significant global health burden, characterized by its morbidity and high mortality rates. The...
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Phytochemicals as potential target on thioredoxin-interacting protein (TXNIP) for the treatment of cardiovascular diseases
Cardiovascular diseases (CVDs) are currently the major cause of death and morbidity on a global scale. Thioredoxin-interacting protein (TXNIP) is a...
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Promising Polyphenols in Parkinson’s Disease Therapeutics
AbstractParkinson’s disease (PD) is a slow progressive, second most common neurodegenerative disease characterized by the loss of dopaminergic...
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Lateral flow immunoassay for small-molecules detection in phytoproducts: a review
Phytoproducts are involved in various fields of industry. Small-molecule (Mw < 900 Da) organic compounds can be used to indicate the quality of plant...
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Flavonoids in Combination with Stem Cells for the Treatment of Neurological Disorders
Neurological disorders are the leading cause of disability and the world's second leading cause of death. Despite the availability of significant...
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Targeting PPARs Signaling Pathways in Cardiotoxicity by Natural Compounds
Cardiotoxicity can be a complication of both drugs and a variety of other chemicals that affects morbidity, quality of life, and even mortality. The...
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Therapeutic role of medicinal plant extracts and bioactive compounds in osteoarthritis
Osteoarthritis (OA) is a musculoskeletal disorder characterized by degeneration of articular cartilages facilitated by inflammation, cartilage and...
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The Potential Role of Bioactive Plant-Based Polyphenolic Compounds and Their Delivery Systems—as a Promising Opportunity for a New Therapeutic Solution for Acute and Chronic Wound Healing
Purpose of ReviewPlant-based polyphenolic compounds are natural by-products known as plant secondary metabolites, which have significant utilities in...
