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Identification of differentially expressed circRNAs and a novel hsa_circ_0000144 that promote tumor growth in gastric cancer
BackgroundCircular RNAs (circRNAs) are involved in regulating tumor pathogenesis. The mechanism of circRNAs in gastric cancer (GC) is still unknown....
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Upregulation of long non-coding RNA LOC284454 may serve as a new serum diagnostic biomarker for head and neck cancers
BackgroundIdentification of effective diagnostic and prognostic biomarkers of cancer is necessary for improving precision medicine. Long non-coding...
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RNA modifications in brain tumorigenesis
RNA modifications are emerging as critical regulators in cancer biology, thanks to their ability to influence gene expression and the predominant...
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Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance
Circular RNAs (circRNAs), one type of non-coding RNA, were initially misinterpreted as nonfunctional products of pre-mRNA mis-splicing. Currently,...
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Changes in Gene Expression
As in many other areas of research, studies on the pathogenesis of fluoride toxicity are involving genetic and epigenetic analyses to an increasing...
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Aberrantly expressed microRNAs and their implications in childhood central nervous system tumors
Even though the treatment of childhood cancer has evolved significantly in recent decades, aggressive central nervous system (CNS) tumors are still a...
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Identification of breast cancer mechanism based on weighted gene coexpression network analysis
Our gene expression-profiling analysis aimed to explain the mechanism of breast cancer development by identifying key pathways and constructing...
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Immunoinflammatory Aspects of Parkinson’s Disease
This review analyzes immunological impairments in Parkinson’s disease (PD). We present data on neuroinflammation, with which cell degeneration in the...
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Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis
Polypyrimidine tract-binding protein 1 (PTBP1) plays an essential role in splicing and is expressed in almost all cell types in humans, unlike the...
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Genetic and molecular biology of breast cancer among Iranian patients
AbstractBackground, Breast cancer (BC) is one of the leading causes of cancer related deaths in Iran. This high ratio of mortality had a rising trend...
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miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells
Endothelial dysfunction is a key element in cerebral small vessel disease (CSVD), which may cause stroke and cognitive decline. Cyclic nucleotide...
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Impairment to Cognitive Functions in Wistar Rats in a Model of the Preclinical Stage of Parkinson’s Disease
The preclinical stage of Parkinson’s disease (PD), when most dopaminergic neurons in the nigrostriatal system of the brain are still intact and...
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Salivary extracellular vesicle-associated miRNAs as potential biomarkers in oral squamous cell carcinoma
BackgroundSeveral studies in the past have investigated the expression of micro RNAs (miRNAs) in saliva as potential biomarkers. Since miRNAs...
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Identification and validation a TGF-β-associated long non-coding RNA of head and neck squamous cell carcinoma by bioinformatics method
BackgroundThe role of transforming growth factorβ (TGF-β)-induced tumor progression in advanced malignancy is well established, but the involvement...
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Diagnosis and Assessment of Microbial Infections with Host and Microbial MicroRNA Profiles
MicroRNAs (miRNAs) encoded by viral genome or host have been found participating in host-microbe interactions. Differential expression profiles of...
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Lipids, lipid metabolism and Kaposi’s sarcoma-associated herpesvirus pathogenesis
Lipids are essential for mammalian cells to maintain many physiological functions. Emerging evidence has shown that cancer cells can...
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Recent progress toward the use of circulating microRNAs as clinical biomarkers
MicroRNAs (miRNAs) have been shown to be critical mediators of many cellular and developmental processes and have been implicated in different human...