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CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model
Interleukin 23 (IL-23) is a key mediator in neuroinflammation in numerous autoimmune diseases including multiple sclerosis (MS). However, the...
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Increased circulating Th17 cell populations in patients with pancreatic ductal adenocarcinoma
T-helper 17 (Th17) cells are a subset of CD4 + helper T cells that produce interleukin 17 (IL-17) and play a crucial role in the pathogenesis of...
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Genetically Engineered Mesenchymal Stem Cell Therapy Against Murine Experimental Autoimmune Encephalomyelitis
We used recombinant interleukin 23 receptor (RIL-23R)-engineered mesenchymal stem cells (MSCs) to study its therapeutic role in enhancing...
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Trichinella spiralis cathepsin L induces macrophage M1 polarization via the NF-κB pathway and enhances the ADCC killing of newborn larvae
BackgroundDuring the early stages of Trichinella spiralis infection, macrophages predominantly undergo polarization to the M1-like phenotype,...
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Allergic airway inflammation induces upregulation of the expression of IL-23R by macrophages and not in CD3 + T cells and CD11c+F4/80− dendritic cells of the lung
Interleukin 23 and the interleukin 23 receptor (IL-23-IL23R) are described as the major enhancing factors for Interleukin 17 (IL-17) in allergic...
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IL-23 contributes to Particulate Matter induced allergic asthma in the early life of mice and promotes asthma susceptibility
AbstractAir pollutant exposure leads to and exacerbates respiratory diseases. Particulate Matter (PM) is a major deleterious factor in the...
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Interleukin-5 levels in relation to malaria severity: a systematic review
BackgroundThe role of cytokines such as interleukin-5 (IL-5) in the pathogenesis of malaria remains unclear. This systematic review sought to...
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IL-23 and the Tumor Microenvironment
The tumor microenvironment (TME), which assists in the development, progression, and metastasis of malignant cells, is instrumental in virtually...
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Co-administration of probiotics and vitamin D reduced disease severity and complications in patients with Parkinson’s disease: a randomized controlled clinical trial
RationaleProbiotics have beneficial effects on the nervous system by modulating the gut-brain axis. Additionally, vitamin D supplementation presents...
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Ameliorative effects of topical ramelteon on imiquimod-induced psoriasiform inflammation in mice
Psoriasis is a long-lasting, immune-related inflammatory skin disease that affects 2–3% of the global population. It is distinguished by...
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Metabolic and inflammatory perturbation of diabetes associated gut dysbiosis in people living with and without HIV infection
BackgroundGut dysbiosis has been linked with both HIV infection and diabetes, but its interplay with metabolic and inflammatory responses in...
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Effect of treatment regimen of the rheumatoid arthritis patients on the risk of coronavirus disease 2019 by modulating the inflammatory mediators
BackgroundThe therapeutic profile of the patients with rheumatoid arthritis (RA) commonly consists of immunosuppressive and anti-inflammatory...
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Anakinra in Sanfilippo syndrome: a phase 1/2 trial
Sanfilippo syndrome is a fatal childhood neurodegenerative disorder involving neuroinflammation among multiple pathologies. We hypothesized that...
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Anti-IL23 biologic therapies in the treatment of psoriasis: real-world experience versus clinical trials data
Nowadays, the biological equipment available for the treatment of moderate-to-severe psoriasis is plenty. Anti-interleukin-23 represents the latest...
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Targeting STING in dendritic cells alleviates psoriatic inflammation by suppressing IL-17A production
Psoriasis is a common chronic inflammatory skin disease driven by the aberrant activation of dendritic cells (DCs) and T cells, ultimately leading to...
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First-in-human phase 1 dose-escalation study of CAN04, a first-in-class interleukin-1 receptor accessory protein (IL1RAP) antibody in patients with solid tumours
BackgroundInterleukin-1 (IL-1) signalling is involved in various protumoural processes including proliferation, immune evasion, metastasis and...
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Differential effects of two phosphodiesterase 4 inhibitors against lipopolysaccharide-induced neuroinflammation in mice
BackgroundSeveral phosphodiesterase 4 (PDE4) inhibitors have emerged as potential therapeutics for central nervous system (CNS) diseases. This study...
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Correction to: Critical role of interleukin-23 in development of asthma promoted by cigarette smoke
The original publication of this paper contains a mistake.
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The ameliorative effects of topical gemifloxacin alone or in combination with clobetasol propionate on imiquimod-induced model of psoriasis in mice
Psoriasis is a lifelong immune-driven skin condition characterized by excessive epidermal overgrowth and inflammatory cell infiltration. Gemifloxacin...
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Interleukin-23 receptor signaling mediates cancer dormancy and radioresistance in human esophageal squamous carcinoma cells via the Wnt/Notch pathway
AbstractIn the tumor microenvironment, inflammatory cells and molecules influence almost every process; among them, interleukin-23 (IL-23) is a...
