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METTL3 depletion contributes to tumour progression and drug resistance via N6 methyladenosine-dependent mechanism in HR+HER2—breast cancer
BackgroundChemotherapy is an important strategy for the treatment of hormone receptor-positive/human epidermal growth factor receptor 2-negative...
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Tumour microenvironment characterisation to stratify patients for hyperthermic intraperitoneal chemotherapy in high-grade serous ovarian cancer (OVHIPEC-1)
BackgroundHyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in patients with Stage III ovarian cancer following interval...
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Identification of mutation patterns and circulating tumour DNA-derived prognostic markers in advanced breast cancer patients
BackgroundThe correlations between circulating tumour DNA (ctDNA)-derived genomic markers and treatment response and survival outcome in Chinese...
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Neo-train: study protocol and feasibility results for a two-arm randomized controlled trial investigating the effect of supervised exercise during neoadjuvant chemotherapy on tumour response in patients with breast cancer
BackgroundPrehabilitation with exercise interventions during neoadjuvant chemotherapy (NACT) is effective in reducing physical and psychosocial...
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Comparative analysis of EpCAM high-expressing and low-expressing circulating tumour cells with regard to their clonal relationship and clinical value
BackgroundCirculating tumour cells (CTCs) are mainly enriched based on the epithelial cell adhesion molecule (EpCAM). Although it was shown that an...
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The emerging role of PI3K inhibitors for solid tumour treatment and beyond
Phosphoinositide 3-kinases (PI3Ks) play a central role in tumourigenesis with recurrent activating mutations of its p110α subunit ( PIK3CA ) identified...
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HIF2α, Hepcidin and their crosstalk as tumour-promoting signalling
Not all aspects of the disruption of iron homeostasis in cancer have been fully elucidated. Iron accumulation in cancer cells is frequent for many...
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Stanniocalcin 2 (STC2): a universal tumour biomarker and a potential therapeutical target
Stanniocalcin 2 (STC2) is a glycoprotein which is expressed in a broad spectrum of tumour cells and tumour tissues derived from human breast,...
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Tumour–host interactions through the lens of Drosophila
There is a large gap between the deep understanding of mechanisms driving tumour growth and the reasons why patients ultimately die of cancer. It is...
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Targeting oncogene and non-oncogene addiction to inflame the tumour microenvironment
Immune checkpoint inhibitors (ICIs) have revolutionized the clinical management of multiple tumours. However, only a few patients respond to ICIs,...
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Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade
Metastasis formation is the main cause of cancer-related death in patients with solid tumours. At the beginning of this process, cancer cells escape...
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Acute effect of high-intensity interval aerobic exercise on serum myokine levels and resulting tumour-suppressive effect in trained patients with advanced prostate cancer
PurposeAlthough skeletal muscle releases cytokines called myokines during exercise, the kinetics of the acute myokine response to exercise...
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Tumour fatty acid metabolism in the context of therapy resistance and obesity
Fatty acid metabolism is known to support tumorigenesis and disease progression as well as treatment resistance through enhanced lipid synthesis,...
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Invasive recurrence after breast conserving treatment of ductal carcinoma in situ of the breast in the Netherlands: time trends and the association with tumour grade
BackgroundThe first aim of this study was to examine trends in the risk of ipsilateral invasive breast cancer (iIBC) after breast-conserving surgery...
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Detection of circulating tumour cells before and following adjuvant chemotherapy and long-term prognosis of early breast cancer
BackgroundThe detection of circulating tumour cells (CTC) is prognostic for disease recurrence in early breast cancer (BC). This study aims to...
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Demographic, tumour, and treatment characteristics of female patients with breast cancer in Sri Lanka; results from a hospital-based cancer registry
BackgroundAlthough breast cancer is the most common cancer among Sri Lankan women, there is little published data on patient characteristics and...
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Tissue clearing to examine tumour complexity in three dimensions
The visualization of whole organs and organisms through tissue clearing and fluorescence volumetric imaging has revolutionized the way we look at...
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Concurrent inhibition of CDK2 adds to the anti-tumour activity of CDK4/6 inhibition in GIST
BackgroundAdvanced gastrointestinal stromal tumour (GIST) is characterised by genomic perturbations of key cell cycle regulators. Oncogenic...
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MDM2 inhibition in combination with endocrine therapy and CDK4/6 inhibition for the treatment of ER-positive breast cancer
BackgroundResistance to endocrine therapy is a major clinical challenge in the management of oestrogen receptor (ER)-positive breast cancer. In this...
