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Clinical and diagnostic characteristics of Hashimoto’s encephalopathy: a single-center, retrospective study
Background and purposeDiagnosing Hashimoto’s encephalopathy (HE) is challenging. In contrast to other types of autoimmune encephalitis, HE shows an...
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COVID-19 and spinal cord injury: clinical presentation, clinical course, and clinical outcomes of people hospitalised
Study designRetrospective study
ObjectivesTo describe the presenting symptoms/signs, clinical course and outcomes in hospitalised people with spinal...
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Clinical Presentation and Prognosis
Over the past three decades, the care for patients with meningioma has steadily improved as a result of a better understanding of the natural...
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Ataxia-telangiectasia in Latin America: clinical features, immunodeficiency, and mortality in a multicenter study
Ataxia-telangiectasia (AT) is a rare genetic disorder leading to neurological defects, telangiectasias, and immunodeficiency. We aimed to study the...
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The comprehensive study on the role of POSTN in fetal congenital heart disease and clinical applications
BackgroundCongenital heart defect (CHD) is the most common congenital abnormality, and it has long been a clinical and public health concern. Our...
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Will artificial intelligence chatbots replace clinical pharmacologists? An exploratory study in clinical practice
PurposeRecently, there has been a growing interest in using ChatGPT for various applications in Medicine. We evaluated the interest of OpenAI chatbot...
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Clinical usefulness of metagenomic next-generation sequencing for Talaromyces marneffei diagnosis in China: a retrospective study
PurposeMetagenomic next-generation sequencing (mNGS) has been widely used in the diagnosis of infectious diseases. However, studies on Talaromyces...
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Clinical Research: Bringing Discoveries from the Lab to the Clinic
A career in clinical research offers an attractive potential career path for PhD graduates. Clinical research is conducted to translate preliminary...
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Job Possibilities in Clinical Research
Clinical research is a vital component when develo** new therapies for patients as it provides evidence that they are safe and effective. The...
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A Qualitative Study of Biomedical Engineering Student Critical Reflection During Clinical Immersion Experiences
PurposeClinical immersion experiences provide engineering students with opportunities to identify unmet user needs and to interact with clinical...
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Relationship of imipenem therapeutic drug monitoring to clinical outcomes in critically ill patients: a retrospective cohort study
The primary objective of this study was to evaluate the predictors associated with target concentration (non-)attainment of imipenem in critically...
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Clinical relevance of distolingual roots and periodontal status in mandibular first molars: a cross-sectional study employing CBCT analysis
ObjectivesDistolingual root of the permanent mandibular first molar (PMFM-DLR) has been frequently reported, which may complicate the treatment of...
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Specific Populations: Clinical Pharmacology Considerations
The ultimate goal of new drug development is to not only show the safety and effectiveness of a drug, but also to ensure that the right dosage is...
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Mothers of children with Down syndrome: a clinical and epidemiological study
Down syndrome is the main genetic cause of intellectual disability. Many studies describe the clinical characteristics of DS patients; however, few...
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Quality by Design in Relation to Clinical Trials
Clinical trials play a crucial role in evaluating the safety and efficacy of new drugs and treatments. Ensuring the quality and integrity of clinical...
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Clinical Rating Scales for Ataxia
Clinical rating scales for ataxia yield a semi-quantitative measure of disease severity. Rating is based on standardized scoring, usually applied on...
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Integrating rapid exome sequencing into NICU clinical care after a pilot research study
Genomic sequencing is a powerful diagnostic tool in critically ill infants, but performing exome or genome sequencing (ES/GS) in the context of a...
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Institutional Review Board Considerations for Clinical Trials
To protect subjects who participate in human research, Institutional Review Boards (IRBs) play an important role in reviewing research and...
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Unusual clinical spectra of childhood severe malaria during malaria epidemic in eastern Uganda: a prospective study
BackgroundIn sub-Saharan Africa (SSA), malaria remains a public health problem despite recent reports of declining incidence. Severe malaria is a...
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Imaging of large volume subcutaneous deposition using MRI: exploratory clinical study results
Subcutaneous (SC) delivery is a preferred route of administration for biotherapeutics but has predominantly been limited to volumes below 3 mL. With...
