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Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer
BackgroundRibosomal biogenesis and ribosomal proteins have attracted attention in the context of tumor biology in recent years. Instead of being mere...
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Widespread alterations in microRNA biogenesis in human Huntington’s disease putamen
Altered microRNA (miRNA) expression is a common feature of Huntington’s disease (HD) and could participate in disease onset and progression. However,...
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Glucose ingestion before and after resistance training sessions does not augment ribosome biogenesis in healthy moderately trained young adults
PurposeResistance training-induced skeletal muscle hypertrophy seems to depend on ribosome biogenesis and content. High glucose treatment may augment...
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Protective effect of resveratrol on mitochondrial biogenesis during hyperoxia-induced brain injury in neonatal pups
BackgroundNeonatal hyperoxic brain injury is caused by exposure to hyperphysiological oxygen content during the period of incomplete development of...
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Exosomes biogenesis was increased in metformin-treated human ovary cancer cells; possibly to mediate resistance
BackgroundExosomes derived from tumor cells contribute to the pathogenesis of cancers. Metformin, the most usually used drug for type 2 diabetes, has...
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Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (mitobiogenesis) and...
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METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known...
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Multi-omics profiling reveals dysregulated ribosome biogenesis and impaired cell proliferation following knockout of CDR2L
BackgroundCerebellar degeneration-related (CDR) proteins are associated with paraneoplastic cerebellar degeneration (PCD) – a rare, neurodegenerative...
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Mitochondrial Biogenesis and Dynamics in Health and Disease
Mitochondria control a myriad of intracellular processes including ATP synthesis, redox balance, ion homeostasis and metabolism of amino acids and...
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SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways
BackgroundOxidative stress-caused damage to the retinal pigment epithelium (RPE) underlies the onset and progression of age-related macular...
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Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis
BackgroundMetabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most prevalent metabolic syndromes worldwide. However, no...
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The additive effects of nicotinamide mononucleotide and melatonin on mitochondrial biogenesis and fission/fusion, autophagy, and microRNA-499 in the aged rat heart with reperfusion injury
The prognosis of myocardial ischemia/reperfusion (I/R) injury is poor in elderly patients. Aging increases the susceptibility of the heart to cell...
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GCN5L1-mediated TFAM acetylation at K76 participates in mitochondrial biogenesis in acute kidney injury
BackgroundMitochondrial dysfunction is an important pathogenic event in acute kidney injury (AKI). GCN5L1 is a specific acetyltransferase in...
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Low level of Fibrillarin, a ribosome biogenesis factor, is a new independent marker of poor outcome in breast cancer
BackgroundA current critical need remains in the identification of prognostic and predictive markers in early breast cancer. It appears that a...
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Live Imaging of Autophagosome Biogenesis and Maturation in Primary Neurons
Live-cell imaging of autophagy in primary neurons has revealed a robust and constitutive pathway for nonselective autophagy in the axon....
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Herbal medicine formula Huazhuo Tiaozhi granule ameliorates dyslipidaemia via regulating histone lactylation and miR-155-5p biogenesis
BackgroundHuazhuo Tiaozhi granule (HTG) is a herbal medicine formula widely used in clinical practice for hypolipidaemic effects. However, the...
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Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer
Extracellular vesicles (EVs), including exosomes, are increasingly recognized as potent mediators of intercellular communication due to their...
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PGC-1α induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma
IntroductionProgress in the knowledge of metabolic interactions between cancer and its microenvironment is ongoing and may lead to novel therapeutic...
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Neuroinflammatory Modulation of Extracellular Vesicle Biogenesis and Cargo Loading
Increasing evidence suggests neuroinflammation is a highly coordinated response involving multiple cell types and utilising several different forms...
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The pre-conception maternal exposure to Sofosbuvir affects the mitochondrial biogenesis in prenatal fetal tissues: Experimental study on rats
BackgroundHepatitis C virus (HCV) infection is a global public health problem and Egypt has the highest HCV prevalence worldwide. Hence, global...
