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Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias
Pick’s disease (PiD) is a subtype of the tauopathy form of frontotemporal lobar degeneration (FTLD-tau) characterized by intraneuronal 3R-tau...
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Region-selective control of the thalamic reticular nucleus via cortical layer 5 pyramidal cells
Corticothalamic pathways, responsible for the top-down control of the thalamus, have a canonical organization such that every cortical region sends...
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CSF tau microtubule-binding region identifies pathological changes in primary tauopathies
Despite recent advances in fluid biomarker research in Alzheimer’s disease (AD), there are no fluid biomarkers or imaging tracers with utility for...
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Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction: a pre-specified analysis of EMPEROR-Preserved
The EMPEROR-Preserved trial showed that the sodium–glucose co-transporter 2 inhibitor empagliflozin significantly reduces the risk of cardiovascular...
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Differential effects of antiretroviral treatment on immunity and gut microbiome composition in people living with HIV in rural versus urban Zimbabwe
BackgroundThe widespread availability of antiretroviral therapy (ART) has dramatically reduced mortality and improved life expectancy for people...
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Diagnostic yield of a risk model versus faecal immunochemical test only: a randomised controlled trial in a colorectal cancer screening programme
BackgroundCombining the faecal immunochemical test (FIT) result with risk factors for advanced neoplasia (AN) may increase the yield of colorectal...
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Chemoradiotherapy versus triplet chemotherapy as initial therapy for T4b esophageal cancer: survival results from a multicenter randomized Phase 2 trial
BackgroundWe report the long-term results as primary endpoint in a multicentre randomized prospective Phase 2 trial which compared chemoradiotherapy...
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Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function
The myelinated white matter tracts of the central nervous system (CNS) are essential for fast transmission of electrical impulses and are often...
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Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice
Fibrotic scar tissue formation occurs in humans and mice. The fibrotic scar impairs tissue regeneration and functional recovery. However, the origin...
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Retention of Virus Versus Surrogate, by Ultrafiltration in Seawater: Case Study of Norovirus Versus Tulane
In the field of chemical engineering and water treatment, the study of viruses, included surrogates, is well documented. Often, surrogates are used...
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Epidemiology of gastrointestinal infections: lessons learned from syndromic testing, Region Zealand, Denmark
The aim of this study was to investigate the value of syndromic diagnostic testing for a better understanding of the epidemiology of gastrointestinal...
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A family with ulcerative colitis maps to 7p21.1 and comprises a region with regulatory activity for the aryl hydrocarbon receptor gene
We have mapped a locus on chromosome 7p22.3-7p15.3 spanning a 22.4 Mb region for ulcerative colitis (UC) by whole genome linkage analyses of a large...
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A randomised controlled trial of Standard Of Care versus RadioAblaTion in Early Stage HepatoCellular Carcinoma (SOCRATES HCC)
BackgroundTherapeutic options for early-stage hepatocellular carcinoma (HCC) in individual patients can be limited by tumor and location, liver...
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Burden of mosquito-borne diseases across rural versus urban areas in Cameroon between 2002 and 2021: prospective for community-oriented vector management approaches
BackgroundOver the past two decades, Cameroon has recorded one of the highest rates of urban population growth in sub-Saharan Africa. It is estimated...
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The efficacy and safety of direct oral anticoagulants versus vitamin K antagonists in patients with left-sided bioprosthetic heart valves and atrial fibrillation: a systematic review and meta-analysis
BackgroundThe efficacy and safety of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) for the treatment of patients with...
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Real-World Clinical Outcomes of Bevacizumab-awwb Biosimilar versus Bevacizumab Reference Product in Patients with Metastatic Colorectal Cancer
BackgroundBevacizumab-awwb was the first biosimilar approved for cancer treatment in the USA. Limited information is available on the real-world...
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The role of surgical tissue injury and intraoperative sympathetic activation in postoperative immunosuppression after breast-conserving surgery versus mastectomy: a prospective observational study
BackgroundBreast cancer is the second most common cause of death from cancer in women worldwide. Counterintuitively, large population-based...
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Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial
Kidney transplantation is the optimal treatment for end-stage renal disease, but it is still severely limited by a lack of suitable organ donors....
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Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
BackgroundThe optic nerve is an important tissue in glaucoma and the unmyelinated nerve head region remains an important site of many early...
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Increased copy number of imprinted genes in the chromosomal region 20q11-q13.32 is associated with resistance to antitumor agents in cancer cell lines
BackgroundParent of origin-specific allelic expression of imprinted genes is epigenetically controlled. In cancer, imprinted genes undergo both...
