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Dihydropyrimidine dehydrogenase gene variants for predicting grade 4-5 fluoropyrimidine-induced toxicity: FUSAFE individual patient data meta-analysis
BackgroundDihydropyrimidine dehydrogenase (DPD) deficiency is the main known cause of life-threatening fluoropyrimidine (FP)-induced toxicities. We...
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An integrated analysis of the competing endogenous RNA network associated of prognosis of stage I lung adenocarcinoma
BackgroundAccumulating evidence indicates that long non-coding RNAs (lncRNAs) are involving in the tumorigenesis and metastasis of lung cancer. The...
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Bioinformatic Analysis of m6A Regulator-Mediated RNA Methylation Modification Patterns and Immune Microenvironment Characterization in Endometriosis
Epigenetic regulation plays an essential role in immunity and inflammation in endometriosis. In this study, we aimed to explore differences in m6A...
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Protein-centric omics integration analysis identifies candidate plasma proteins for multiple autoimmune diseases
It remains challenging to translate the findings from genome-wide association studies (GWAS) of autoimmune diseases (AIDs) into interventional...
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Construction of a prognostic model for lung adenocarcinoma based on heat shock protein-related genes and immune analysis
Lung adenocarcinoma (LUAD) represents a prevalent form of cancer, with low early diagnosis rates and high mortality rates, posing a global health...
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Amino acids and risk of colon adenocarcinoma: a Mendelian randomization study
BackgroundThe existence of amino acid metabolic reprogramming in tumor cells is well established. However, the potential correlation between blood...
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Causal inference between pernicious anemia and cancers: a bidirectional two-sample mendelian randomization analysis
BackgroundObservational study investigated the association between pernicious anemia (PA) and cancers. However, with the exception of gastric cancer,...
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Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants
BackgroundIrritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction frequently accompanied by mental conditions, including...
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Understanding Barriers and Distress Experienced Among Cancer Patients: Analysis from an Urban Academic Emergency Department
The purpose of this study was to examine barriers and facilitators to compliance for cancer care in patients utilizing an emergency department...
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Causal associations between chronic hepatitis B and COVID-19 in East Asian populations
BackgroundThe relationship between chronic hepatitis B (CHB) and Coronavirus disease 2019 (COVID-19) has been inconsistent in traditional...
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Comprehensive analysis of prognostic immune-related genes and drug sensitivity in cervical cancer
BackgroundCervical cancer (CC) is the leading cause of cancer-related death in women. A limited number of studies have investigated whether...
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An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease
Multivariate methods are known to increase the statistical power to detect associations in the case of shared genetic basis between phenotypes. They...
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An integrated framework for local genetic correlation analysis
Genetic correlation ( r g ) analysis is used to identify phenotypes that may have a shared genetic basis. Traditionally, r g is studied globally,...
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Identification of SUMOylation-related biomarkers in papillary thyroid carcinoma
BackgroundSmall ubiquitin-like modifier (SUMO) modification is increasingly recognized as critical in tumorigenesis and progression. This study...
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GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture
Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments....
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Sex differences of the shared genetic landscapes between type 2 diabetes and peripheral artery disease in East Asians and Europeans
Type 2 diabetes (T2D) is a critical risk factor for peripheral artery disease (PAD). However, the sex differences in genetic basis, causality, and...
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Evaluation for causal effects of socioeconomic traits on risk of female genital prolapse (FGP): a multivariable Mendelian randomization analysis
BackgroundAlthough observational studies have established some socioeconomic traits to be independent risk factors for pelvic organ prolapse (POP),...
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Systematic pan-cancer analysis of mutation–treatment interactions using large real-world clinicogenomics data
Quantifying the effectiveness of different cancer therapies in patients with specific tumor mutations is critical for improving patient outcomes and...
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5Apal, Taql, Fokl, and Bsml polymorphisms and the susceptibility of Behcet’s disease: an updated meta-analysis
ObjectiveThe aim of this study was to investigate whether the gene polymorphisms of vitamin D receptor (VDR) had a genetic effect on the...
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High expression of LAMA3/AC245041.2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis
BackgroundPancreatic adenocarcinoma (PAAD) is one of the most challenging cancers with high morbidity and mortality. KRAS mutations could occur as an...
