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Alterations to DNA methylation patterns induced by chemotherapy treatment are associated with negative impacts on the olfactory pathway
BackgroundExposure to cytotoxic chemotherapy treatment may alter DNA methylation (DNAm) in breast cancer patients.
MethodsWe performed DNAm analysis...
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Features of metabolism associated molecular patterns in pancreatic ductal adenocarcinoma
Exploring pancreatic ductal adenocarcinoma (PDAC) metabolic landscape would contribute to further understand PDAC from the metabolic perspective and...
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Initial and ten-year treatment patterns among 11,000 breast cancer patients undergoing breast surgery—an analysis of German claims data
BackgroundWe aimed to explore the potential of German claims data for describing initial and long-term treatment patterns of breast cancer patients...
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Contemporary treatment patterns and survival of cervical cancer patients in Ethiopia
BackgroundCervical cancer is the second commonly diagnosed cancer and the second leading cause of cancer death in women in Ethiopia, with rates among...
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Trends in treatment patterns and survival outcomes in advanced non-small cell lung cancer: a Canadian population-based real-world analysis
BackgroundAs part of the multi-country I-O Optimise research initiative, this population-based study evaluated real-world treatment patterns and...
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Treatment patterns and effectiveness of patients with multiple myeloma initiating Daratumumab across different lines of therapy: a real-world chart review study
BackgroundDaratumumab, a CD38 monoclonal antibody, has demonstrated efficacy as monotherapy and combination therapy across several indications, both...
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Clinical factors associated with patterns of endocrine therapy adherence in premenopausal breast cancer patients
IntroductionPatients with hormone receptor positive breast cancer are recommended at least five years of adjuvant endocrine therapy, but adherence to...
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Treatment of Hepatitis E
Hepatitis E virus (HEV) infections are the most common cause of acute hepatitis, but they can also take a chronic course. There is no specific...
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Single-cell aggrephagy-related patterns facilitate tumor microenvironment intercellular communication, influencing osteosarcoma progression and prognosis
Osteosarcoma, a common malignant tumor in children, has emerged as a major threat to the life and health of pediatric patients. Presently, there are...
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Exploring racial disparities in treatment patterns and outcomes for patients with multiple myeloma using real world data
This retrospective observational study evaluated racial disparities among Black and White patients with multiple myeloma (MM). We included patients...
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Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer
BackgroundThe role of cholesterol metabolism in gastric cancer (GC) and its implications for tumor characteristics and immunotherapy response remain...
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Utilization patterns of cardiovascular medications in patients with diabetes mellitus; a retrospective cross-sectional study, 2013-17
BackgroundDiabetes Mellitus (DM) is a prominent health care issue worldwide. One of the most prevalent comorbidities of DM is cardiovascular disease...
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Transcriptomic characterization of the histopathological growth patterns in breast cancer liver metastases
Metastatic breast cancer (mBC) remains incurable and liver metastases (LM) are observed in approximately 50% of all patients with mBC. In some cases,...
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Histopathological growth patterns and tumor-infiltrating lymphocytes in breast cancer liver metastases
Liver is the third most common organ for breast cancer (BC) metastasis. Two main histopathological growth patterns (HGP) exist in liver metastases...
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Immune cell patterns before and after neoadjuvant immune checkpoint blockade combined with chemoradiotherapy in locally advanced esophageal squamous cell carcinoma
BackgroundNeoadjuvant immune checkpoint blockade (ICB) combined with chemoradiotherapy offers high pathologic complete response (pCR) rate for...
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Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases
Little is known about the genetic determinants of medication use in preventing cardiometabolic diseases. Using the Finnish nationwide drug purchase...
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Effect of Diet Patterns in the Prevention of Alzheimer’s Disease
There are over 55 million people living with dementia worldwide. Alzheimer’s disease (AD) is the most common type of dementia and likely comprises up...
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A real-world retrospective study of the use of Ki-67 testing and treatment patterns in patients with HR+, HER2− early breast cancer in the United States
BackgroundThe National Comprehensive Cancer Network recommends that patients with hormone receptor-positive early breast cancer be considered for...
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DNA hypomethylation patterns and their impact on the tumor microenvironment in colorectal cancer
BackgroundRecent research underscores the pivotal role of immune checkpoints as biomarkers in colorectal cancer (CRC) therapy, highlighting the...
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Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns
Whole chromosome and arm-level copy number alterations occur at high frequencies in tumors, but their selective advantages, if any, are poorly...
