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1. TOX deficiency facilitates the differentiation of IL-17A-producing γδ T cells to drive autoimmune hepatitis

   The specification of the αβ/γδ lineage and the maturation of medullary thymic epithelial cells (mTECs) coordinate central tolerance to self-antigens....

   Qifeng He, Yijun Lu, ... Beicheng Sun in Cellular & Molecular Immunology

   Article 19 August 2022
   

2. Revelations in Thymic Epithelial Cell Biology and Heterogeneity from Single-Cell RNA Sequencing and Lineage Tracing Methodologies

   Thymic epithelial cells (TECs) make up the thymic microenvironments that support the generation of a functionally competent and self-tolerant T-cell...

   Abigail Morales-Sanchez, Susannah C. Shissler, ... Avinash Bhandoola in T-Cell Development

   Protocol 2023
   

3. Reactive Alterations in Thymic Lymphocytopoiesis to Short-Term Decrease in Deuterium Content in the Body

   We studied changes in thymic lymphocytopoiesis induced by a short-term decrease in deuterium content in the body. The experiment was performed on...

   N. V. Yaglova, S. S. Obernikhin, ... V. V. Yaglov in Bulletin of Experimental Biology and Medicine

   Article 01 August 2022

4. Germline-enforced enrichment for charged amino acids in TCR beta chain (TCRβ) complementarity determining region 3 (CDR-B3) alters T cell development, repertoire content, and antigen recognition

   T cell receptor beta chain (TCRβ) diversity (Dβ) gene segments are highly conserved across evolution, with trout Dβ1 sequence identical to human and...

   Michael Levinson, Mohamed Khass, ... Harry W Schroeder in Immunogenetics

   Article 29 April 2023
   

5. Molecular Structural Features that Determine the Neurotropic Activity of Thiamine Derivatives

   Despite numerous studies, high sensitivity of the brain nerve cells to vitamin B1 (thiamine) deficiency could not be explained solely by the...

   Yu. M. Parkhomenko, A. I. Vovk, ... L. I. Chekhivska in Neurophysiology

   Article 12 April 2024

6. The function of Wtap in N⁶-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells

   T cell antigen-receptor (TCR) signaling controls the development, activation and survival of T cells by involving several layers and numerous...

   Taku Ito-Kureha, Cristina Leoni, ... Vigo Heissmeyer in Nature Immunology

   Article 25 July 2022
   

7. Delayed maturation of thymic epithelium in mice with specific deletion of β-catenin gene in FoxN1 positive cells

   Wnt signalling pathways have been reported to be involved in thymus development but their precise role in the development of both thymic epithelium...

   Sara Montero-Herradón, Agustín G. Zapata in Histochemistry and Cell Biology

   Article Open access 12 July 2021
   

8. TCR repertoire landscape reveals macrophage-mediated clone deletion in endotoxin tolerance

   Background

   Endotoxin tolerance (ET) is a protective mechanism in the process of sepsis, septic shock, and their sequelae including uncontrolled...

   Juanjuan Zhao, Li Jia, ... Lin Xu in Inflammation Research

   Article Open access 12 January 2023
   

9. The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8αα⁺ intraepithelial lymphocyte precursors

   While T cell receptor (TCR) αβ ⁺ CD8α ⁺ CD8β ^– intraepithelial lymphocytes (CD8αα ⁺ IELs) differentiate from thymic IEL precursors (IELps) and contribute...

   Jia Nie, Andrea C. Carpenter, ... Rémy Bosselut in Nature Immunology

   Article 30 March 2022
   

10. Cytokine Receptor Signaling and CD4/CD8 Lineage Choice during T Cell Development in the Thymus

    The adaptive immune system is controlled by the concerted action of two major populations of T cells, i.e., helper T cells that express the...

    Megan A. Luckey, Jung Hyun Park in Mathematical, Computational and Experimental T Cell Immunology

    Chapter 2021
    

11. Targeting lysophosphatidic acid receptor with Ki16425 impedes T cell lymphoma progression through apoptosis induction, glycolysis inhibition, and activation of antitumor immune response

    Lysophosphatidic acid (LPA) is a small phospholipid that acts as an extracellular lipid mediator. It promotes cancer progression by altering a wide...

    Vishal Kumar Gupta, Ajay Kumar in Apoptosis

    Article 02 April 2022
    

12. SRSF1 plays a critical role in invariant natural killer T cell development and function

    Invariant natural killer T (iNKT) cells are highly conserved innate-like T lymphocytes that originate from CD4 ⁺ CD8 ⁺ double-positive (DP) thymocytes....

    **g**g Liu, Menghao You, ... Shuyang Yu in Cellular & Molecular Immunology

    Article 14 September 2021
    

13. T Cell Development and T Cell Receptor Structure

    B and T lymphocytes differentiate from the common lymphoid progenitor in the bone marrow. While B cells develop in the bone marrow, thymocytes...

    Tobili Y. Sam-Yellowe in Immunology: Overview and Laboratory Manual

    Chapter 2021
    

14. TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4⁺CD8⁺ thymocytes

    Thymocyte development requires a complex orchestration of multiple transcription factors. Ablating either TCF-1 or HEB in CD4 ⁺ CD8 ⁺ thymocytes elicits...

    Akinola Olumide Emmanuel, Stephen Arnovitz, ... Fotini Gounari in Nature Immunology

    Article 12 November 2018
    

15. Cytotoxicity of Aluminum-Silica Matrices Modified with Carbon Nanotubes

    We studied the effect of aluminum-silicon matrices modified with carbon nanotubes on proliferation and production of nitric oxide by splenocytes,...

    A. P. Lykov, L. N. Rachkovskaya, ... A. Y. Letyagin in Bulletin of Experimental Biology and Medicine

    Article 28 September 2020

16. PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape

    Adaptive immunity relies on specialized effector functions elicited by lymphocytes, yet how antigen recognition activates appropriate effector...

    Noah Gamble, Alexandra Bradu, ... Andrew S. Koh in Nature Immunology

    Article 17 April 2024
    

17. Thymic Education

    in Dictionary of Toxicology

    Reference work entry 2024
    

18. Selective involution of thymic medulla by cyclosporine A with a decrease of mature thymic epithelia, XCR1⁺ dendritic cells, and epithelium-free areas containing Foxp3⁺ thymic regulatory T cells

    Immunosuppressive drugs such as cyclosporine A (CSA) can disrupt thymic structure and functions, ultimately inducing syngeneic/autologous...

    Yasushi Sawanobori, Yusuke Kitazawa, ... Nobuko Tokuda in Histochemistry and Cell Biology

    Article Open access 16 May 2021
    

19. Thymic Atrophy and Immune Dysregulation in Infants with Complex Congenital Heart Disease

    Congenital heart disease (CHD) is the most common birth defect, and up to 50% of infants with CHD require cardiovascular surgery early in life....

    Sarah-Jolan Bremer, Annika Boxnick, ... Anna Gieras in Journal of Clinical Immunology

    Article Open access 23 February 2024
    

20. The gene expression profile and cell of origin of canine peripheral T-cell lymphoma

    Background

    Peripheral T-cell lymphoma (PTCL) refers to a heterogenous group of T-cell neoplasms with poor treatment responses and survival times....

    Eileen Owens, Lauren Harris, ... Anne Avery in BMC Cancer

    Article Open access 02 January 2024