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Screening Methods for the Evaluation of Antitussives and Expectorants
Cough is one of the reflexes that is protective in nature, however it can be distressing if untreated. The number of animal models to study...
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Endoplasmic reticulum stress: a vital process and potential therapeutic target in chronic obstructive pulmonary disease
BackgroundChronic obstructive pulmonary disease (COPD), a chronic and progressive disease characterized by persistent respiratory symptoms and...
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Physiological and immunological barriers in the lung
The lungs serve as the primary organ for respiration, facilitating the vital exchange of gases with the bloodstream. Given their perpetual exposure...
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Gastrointestinal effects of Mentha aquatica L. essential oil
Found in humid regions and waterways and popularly used to treat gastrointestinal problems among other applications, the present study evaluated the M....
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Recombinant Human Deoxyribonuclease I
Human deoxyribonuclease I (DNase I) is an endonuclease that catalyzes the hydrolysis of extracellular DNA and is just one of the numerous types of...
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LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus
The gastrointestinal (GI) mucosa is coated with a continuously secreted mucus layer that serves as the first line of defense against invading enteric...
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Introduction to Vomitus and Its Forensic Analysis
Vomiting is a gastrointestinal response to poisoning or drug overdose and also it can occur due to trauma faced in violent assault like in case of...
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Histological differentiation of mucus cell subtypes suggests functional compartmentation in the eel esophagus
We investigated the morphological and histological changes in eel esophagus during the course of freshwater (FW) to seawater (SW) transfer and...
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Ovalbumin and cholera toxin delivery to buccal mucus for immunization using microneedles and comparison of immunological response to transmucosal delivery
The oral mucosa is an effective site for vaccination. However, for oral mucosal vaccines, delivery of the right dose of vaccine is not possible due...
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Exendin-4 restores airway mucus homeostasis through the GLP1R-PKA-PPARγ-FOXA2-phosphatase signaling
Goblet cell hyperplasia and metaplasia and excessive mucus are prominent pathologies of chronic airway diseases such as chronic obstructive pulmonary...
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Epithelial 5-HT4 Receptors as a Target for Treating Constipation and Intestinal Inflammation
Because of their importance in the regulation of gut functions, several therapeutic targets involving serotonin-related proteins have been developed...
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Fundamentals of Bicarbonate Secretion in Epithelia
Certain epithelia secrete HCO3− to drive fluid secretion, to modify luminal pH and properties of secreted mucus, and to fulfill other functions of a...
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Optimization of Lung Surfactant Coating of siRNA Polyplexes for Pulmonary Delivery
PurposeThe aim of this study was to understand how coating with a pulmonary surfactant, namely Alveofact, affects the physicochemical parameters as...
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Echinochrome exhibits anti-asthmatic activity through the suppression of airway inflammation, oxidative stress, and histopathological alterations in ovalbumin-induced asthma in BALB/c mice
Asthma is a chronic pulmonary disease with marked infiltrating inflammatory cells and reduced respiratory performance. Echinochrome (Ech) is a...
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Effects of natural products on functional constipation: analysis of active ingredient and mechanism
Constipation is a prevalent clinical ailment of the gastrointestinal system, yet its pathogenesis remains ambiguous. Despite the availability of...
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Silver nanoparticles synthesized from Quercus brantii ameliorated ethanol-induced gastric ulcers in rats by decreasing oxidative stress and improving antioxidant systems
Gastric ulcers are caused by an imbalance between aggressive and defensive factors. The green synthesis of silver nanoparticles is becoming a new and...
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Comparison of body wall histologic structure of two medicinal leeches Hirudo sulukii and Hirudo verbana (Hirudinida: Hirudinidae)
In this study, it was aimed to determine secretory cell types using histochemical properties of secretory cells and epidermis histology in the body...
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Influence of zinc and gallic acid on haematological alterations, hepatic and intestinal toxicity induced by sub-acute exposure to Dibutyl-n-phthalate (DBP) in Wistar rats
ObjectiveDibutyl- n -phthalate (DBP) is utilized industrially as a plasticizer, as well as in consumer products, food processing and medical...
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Comparison of viromes in vaginal secretion from pregnant women with and without vaginitis
BackgroundAlthough some studies have investigated the bacterial community in vaginal tract of pregnant women, there are few reports about the viral...
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Revealing the pathogenesis of gastric intestinal metaplasia based on the mucosoid air-liquid interface
BackgroundGastric intestinal metaplasia (GIM) is an essential precancerous lesion. Although the reversal of GIM is challenging, it potentially brings...
