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Antigen-Presenting Cells and MHCs
In this chapter, we will discuss the principles of antigen presentation. We will learn that the major purpose of antigen-presenting cells, such as...
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Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects
The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on the cell surface, which provided the immune system with...
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Immunotherapy for Cervical Cancer
Cervical cancer is a highly prevalent gynecological malignancy worldwide, and it is associated with high-risk human papillomavirus (HPV) infection....
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Enhanced activation of human NK cells by drug-exposed hepatocytes
Drug-induced liver injury (DILI) represents one of the major causes why drugs have to be withdrawn from the market. In this study, we describe a new...
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The correlation of EZH2 expression with the progression and prognosis of hepatocellular carcinoma
BackgroundEnhancer of Zeste homologue 2 (EZH2) is a polycomb group gene and an epigenetic regulator that inhibits transcription, a modification...
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Immunogenetics of Lupus Erythematosus
Lupus erythematosus (LE) is a heterogeneous disease with a wide range of manifestations ranging from localized lesions in cutaneous lupusCutaneous...
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Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
BackgroundAbout 25% of patients with acute hepatitis C virus (HCV) infection show spontaneous clearance within the first six months of infection but...
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Mechanisms of immune activation and regulation: lessons from melanoma
Melanoma, a skin cancer that develops from pigment cells, has been studied intensively, particularly in terms of the immune response to tumours, and...
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Identification of HSP90B1 in pan-cancer hallmarks to aid development of a potential therapeutic target
Heat shock proteins play crucial roles in various biochemical processes, encompassing protein folding and translocation. HSP90B1, a conserved member...
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Candida albicans ergosterol disorders as a consequence of the new sulfone derivative action mode
A series of novel sulfone derivatives were synthesized and screened in vitro for their cytotoxicity and antifungal activity with annotated primary...
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Metastasis Prevention: Focus on Metastatic Circulating Tumor Cells
Metastasis is the main cause of cancer death. Metastatic foci are derived from tumor cells that detach from the primary tumor and then enter the...
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PSMD8 can serve as potential biomarker and therapeutic target of the PSMD family in ovarian cancer: based on bioinformatics analysis and in vitro validation
BackgroundThe ubiquity-proteasome system is an indispensable mechanism for regulating intracellular protein degradation, thereby affecting human...
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CD5L-associated gene analyses highlight the dysregulations, prognostic effects, immune associations, and drug-sensitivity predicative potentials of LCAT and CDC20 in hepatocellular carcinoma
BackgroundThe dysregulation of CD5L has been reported in hepatocellular carcinoma (HCC). However, its functions in HCC were controversial. In this...
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Invasion und Metastasierung
Dieses Kapitel beschreibt Prozesse, Moleküle und Wechselwirkungen, die zur Invasion und Metastasierung beitragen, die am stärksten definierenden...
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Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma
BackgroundMultiple myeloma (MM) is an incurable disease. The acquisition of resistance to drugs, including immunomodulatory drugs (IMiDs), has a...
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Integrative analyses highlight functional regulatory variants associated with neuropsychiatric diseases
Noncoding variants of presumed regulatory function contribute to the heritability of neuropsychiatric disease. A total of 2,221 noncoding variants...
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Antigen-Presenting Cells and the Major Histocompatibility Complex
In this chapter, we will discuss the principles of antigen presentation. We will learn that the major purpose of antigen-presenting cells, such as...
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Evaluation of two laboratory model methods for diarrheal irritable bowel syndrome
BackgroundDiarrheal irritable bowel syndrome (IBS-D) is a common chronic functional gastrointestinal disorder, and the underlying pathogenic...
