Search
Search Results
-
The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
BackgroundTumor-associated macrophages (TAMs) are associated with unfavorable patient prognosis in many cancer types. However, TAMs are a...
-
Ancient ubiquitous protein 1 (AUP1) is a prognostic biomarker connected with TP53 mutation and the inflamed microenvironments in glioma
IntroductionGlioblastoma (GBM) is the most common and lethal brain tumor. The current treatment is surgical removal combined with radiotherapy and...
-
Nine-factor-based immunohistochemistry classifier predicts recurrence for early-stage hepatocellular carcinoma after curative resection
BackgroundImmunoscore have shown a promising prognostic value in many cancers. We aimed to establish and validate an immune classifier to predict...
-
Interplay between WNT/PI3K-mTOR axis and the microbiota in APC-driven colorectal carcinogenesis: data from a pilot study and possible implications for CRC prevention
BackgroundWnt/β-catenin signalling impairment accounts for 85% of colorectal cancers (CRCs), including sporadic and familial adenomatous polyposis...
-
Tumor-infiltrating Lymphocytes as Markers of the Antitumor Therapy Efficacy: Myth or Reality?
Tumor-infiltrating lymphocytes (TIL) are an important prognostic factor of the antitumor therapy effectiveness and the course of the malignant...
-
The role of biomarkers in personalized immunotherapy
BackgroundImmune checkpoint inhibitors have revolutionized cancer therapeutic paradigm and substantially improved the survival of patients with...
-
-
Perspectives in Immunotherapy: meeting report from the Immunotherapy Bridge, December 1st–2nd, 2021
Over the past decade, immunotherapy has become an increasingly fundamental modality in the treatment of cancer. The positive impact of immune...
-
Impact of preoperative white blood cell count on outcomes in different stage colorectal cancer patients undergoing surgical resection: a single-institution retrospective cohort study
PurposeTo explore the association between preoperative WBC count and the long-term survival outcomes and clinical outcomes in different stage...
-
Intraepithelial lymphocytes are indicators of better prognosis in surgically resected endometrioid-type endometrial carcinomas at early and advanced stages
BackgroundTumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) may be useful prognostic indicators in endometrial cancer....
-
Cancer Immunotherapy Clinical Trials
Immunotherapy is a relatively new method of treatment used in oncology. Cancer immunotherapy, also known as immuno-oncology (IO), is a form of cancer...
-
Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer
BackgroundAlthough high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of...
-
The prognostic and biology of tumour-infiltrating lymphocytes in the immunotherapy of cancer
Tumour immunotherapy has achieved remarkable clinical success in many different types of cancer in the past two decades. The outcome of immune...
-
Opposing roles by KRAS and BRAF mutation on immune cell infiltration in colorectal cancer – possible implications for immunotherapy
BackgroundThe immune response has important clinical value in colorectal cancer (CRC) in both prognosis and response to immunotherapy. This study...
-
The Hurdle of Precision Medicine in Cancer Immunotherapy: Personalization Now or Then?
Moving away from the generic treatment for all cancer, precision medicine provides a targeted therapy based on the different profile presented. Since...
-
The therapeutic and prognostic implications of immunobiology in colorectal cancer: a review
Colorectal cancer represents the second leading cause of cancer-related death worldwide. The therapeutic field of immuno-oncology has rapidly gained...
-
Introduction on Cancer Immunodiagnosis
With the increasing burden of cancer, there is a growing need for efficient diagnostic, prognostic and prediction tools to facilitate patient...
-
A novel patient-derived meningioma spheroid model as a tool to study and treat epithelial-to-mesenchymal transition (EMT) in meningiomas
Meningiomas are the most common intracranial brain tumours. These tumours are heterogeneous and encompass a wide spectrum of clinical aggressivity....
-
Expression of CIB1 correlates with colorectal liver metastases but not with peritoneal carcinomatosis
BackgroundMolecular differences in colorectal cancer (CRC) are associated with the metastatic route. Patient survival is mainly driven by metastatic...
-
Role of a lipid metabolism-related lncRNA signature in risk stratification and immune microenvironment for colon cancer
BackgroundEnergy metabolism disorder, especially lipid metabolism disorder, is an important biological characteristic of colon cancer. This research...
