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Does change in barometric pressure per given time at high altitude influence symptoms of acute mountain sickness on Mount Fuji? A pilot study
BackgroundAcute mountain sickness (AMS) is a common, transient condition characterized primarily by headaches, and it can also be associated with...
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Human adaptation to high altitude: a review of convergence between genomic and proteomic signatures
Both genomics- and proteomics-based investigations have identified several essential genes, proteins, and pathways that may facilitate human adaptive...
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Protective effects of epigallocatechin-3-gallate counteracting the chronic hypobaric hypoxia-induced myocardial injury in plain-grown rats at high altitude
Exposure to hypobaric hypoxia (HH) environment causes stress to the body, especially the oxygen-consuming organs. Chronic HH conditions have adverse...
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Predicting an Athlete’s Physiological and Haematological Response to Live High-Train High Altitude Training Using a Hypoxic Sensitivity Test
PurposeElite endurance runners frequently utilise live high-train high (LHTH) altitude training to improve endurance performance at sea level (SL)....
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Enteric glial cells aggravate the intestinal epithelial barrier damage by secreting S100β under high-altitude conditions
Damage to the intestinal epithelial barrier (IEB) has been reported under high-altitude (HA) conditions and may be responsible for HA-associated...
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Serum and Plasma Proteomics for High Altitude Related Biomarker Discovery
Serum and plasma are widely used biological fluids for a large variety of biochemical and pathological tests which have been used since historical...
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High Altitude Induced Thrombosis: Challenges and Recent Advancements in Pathogenesis and Management
Venous thrombosis and pulmonary embolism together form a serious disorder of accelerated and unwanted intravascular blood clot formation which is...
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Factors Affecting Sea-Level Performance Following Altitude Training in Elite Athletes
Live high train high (LHTH) is the original method of altitude training used by elite athletes to enhance sea-level performance. Whilst many...
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High Altitude-Induced Oxidative Stress, Rheumatoid Arthritis, and Proteomic Alteration
Oxidative stress is the disruption in the equilibrium between the production of pro-oxidants such as peroxynitrite (ONOO−), reactive oxygen species...
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AZU1 (HBP/CAP37) and PRKCG (PKC-gamma) may be candidate genes affecting the severity of acute mountain sickness
BackgroundAcute Mountain Sickness (AMS) is one of the diseases that predispose to sudden ascent to high altitudes above 2500 m. Among the many...
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High Altitude Related Diseases: Milder Effects, HACE, HAPE, and Effect on Various Organ Systems
Proteomics has emerged as an excellent biomarker discovery tool in recent years owing to the rapid emergence and growth of high throughput proteomics...
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Oxidative Stress, ROS Generation, and Associated Molecular Alterations in High Altitude Hypoxia
High altitude especially above 3000 m of elevation is considered a potential risk for rapid ascent, while at elevation above 5500 m, it poses life...
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Utilization of Ischemic Preconditioning for Athletes Competing and Training at Altitude: Applications and Perspectives
Acute exposure to altitude negatively impacts exercise tolerance and reduces athletes’ race performance due to lower atmospheric and body tissues...
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Epigallocatechin-3-Gallate Ameliorated Iron Accumulation and Apoptosis and Promoted Neuronal Regeneration and Memory/Cognitive Functions in the Hippocampus Induced by Exposure to a Chronic High-Altitude Hypoxia Environment
We aimed to explore the protective effects and potential treatment mechanism of Epigallocatechin-3-gallate (EGCG) in an animal model of chronic...
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Olfactory Response to Altitude Hypoxia: A Pilot Study During a Himalayan Trek
The adaptation of olfaction to extreme environments is an area of limited understanding. This study aimed to get insights into the factors that...
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Prevention of Pro-inflammatory Markers By Medicinal Mushrooms Under Stressful Environment
Hypoxia and inflammation are vicious cycles and often difficult to point out which signal activates first, and often these signals reinforce in a...
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Splenic contraction is enhanced by exercise at simulated high altitude
PurposeSplenic contraction increases circulating hemoglobin (Hb) with advantages during hypoxia. As both hypoxia and exercise have been shown to be...
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The pathophysiological mechanism of ischemic stroke after hypobaric hypoxia simulation at high altitude
Tibet is an area in China with a high incidence of stroke, typically attributed to hypobaric hypoxia. The present study aimed to observe the neuronal...
