Search
Search Results
-
Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis
BackgroundOur previous report suggested that centrosomal P4.1-associated protein (CPAP) is required for Hepatitis B virus (HBV) encoded non-structure...
-
Correction to: miR-3928v is induced by HBx via NF-ÎşB/EGR1 and contributes to hepatocellular carcinoma malignancy by down-regulating VDAC3
An amendment to this paper has been published and can be accessed via the original article.
-
Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes
HBV is considered as a “stealth” virus that does not invoke interferon (IFN) responses; however, the mechanisms by which HBV bypasses innate immune...
-
Leberkrebs
Leberkrebs ist weltweit eine der tödlichsten Krebsarten. Dieses Kapitel beschreibt die molekulare Pathogenese des wichtigsten histologischen Subtyps,...
-
Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation
PurposeHepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC), which has a male predominance, lacks effective therapeutic options....
-
Hepatitis B virus X protein promotes liver cell pyroptosis under oxidative stress through NLRP3 inflammasome activation
ObjectiveHepatitis B virus X protein (HBx) is a pivotal factor for HBV-induced hepatitis. Herein, we sought to investigate HBx-mediated NLR pyrin...
-
Effects of neddylation on viral infection: an overview
Neddylation is a post-translational modification that plays an important role not only in cancer development but also in regulating viral infection...
-
HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression
BackgroundHepatoma is a common malignancy of the liver. The abnormal high expression of alpha-fetoprotein (AFP) is intimately associated with...
-
HBV X protein-based therapeutic vaccine accelerates viral antigen clearance by mobilizing monocyte infiltration into the liver in HBV carrier mice
BackgroundHepatitis B virus (HBV) persistently infected about 250 million people worldwide, and a curative treatment remains an unmet medical need....
-
Notch Signaling and Liver Cancer
Interactions between liver cells are closely regulated by Notch signaling. Notch signaling has been reported clinically related to bile duct...
-
Liver Cancer
Liver cancer is a major lethal malignancy worldwide. This chapter describes the molecular pathogenesis of the main histological subtype,...
-
Abnormal protein SUMOylation in liver disease: novel target for therapy
SUMOylation is an important protein post-translational modification (PTM) process, in which the small ubiquitin-like modifier (SUMO) protein...
-
Significance of hepatitis B virus capsid dephosphorylation via polymerase
BackgroundIt is generally believed that hepatitis B virus (HBV) core protein (HBc) dephosphorylation (de-P) is important for viral DNA synthesis and...
-
RNA m6A methylation regulators in liver cancer
Liver cancer is one of the most common cancers in the world and a primary cause of cancer-related death. In recent years, despite the great...
-
miR-3188 inhibits hepatitis B virus transcription by targeting Bcl-2
Transcription of the covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is subject to dual regulation by host factors and viral...
-
The association of HBV infection and head and neck cancer: a systematic review and meta-analysis
BackgroundHepatitis B virus (HBV) infections is an important public health problem worldwide and closely affect extrahepatic cancer. Several recent...
-
Major genomic mutations driving hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a subtype of highly malignant carcinoma that occurs in the liver, improved understanding of the mechanisms behind...
-
In Vivo, Ex Vivo, and In Vitro Model Systems for Liver Cancer Research
Cancer claims the lives of millions of people worldwide. Liver cancer represents one such form of cancer that has a high incidence with a poor...
-
Short-chain fatty acids in cancer pathogenesis
Cancer is a multi-step process that can be viewed as a cellular and immunological shift away from homeostasis in response to selected infectious...
-
Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer
BackgroundFirst identified in Drosophila melanogaster , the Hippo pathway is considered a major regulatory cascade controlling tissue homeostasis and...
