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Development of a rational framework for the therapeutic efficacy of fecal microbiota transplantation for calf diarrhea treatment
BackgroundEstablishing fecal microbiota transplantation (FMT) to prevent multifactorial diarrhea in calves is challenging because of the differences...
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Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments
BackgroundFecal microbiota transplantation (FMT) and fecal virome transplantation (FVT, sterile filtrated donor feces) have been effective in...
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Gut microbiota restoration through fecal microbiota transplantation: a new atopic dermatitis therapy
The pathogenesis of atopic dermatitis (AD) involves complex factors, including gut microbiota and immune modulation, which remain poorly understood....
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Mechanistic and physiological approaches of fecal microbiota transplantation in the management of NAFLD
Non-alcoholic fatty liver disease (NAFLD) is a multifaceted disease allied with various metabolic disorders, obesity and dysbiosis. Gut microbiota...
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The Efficacy of Fecal Transplantation and Bifidobacterium Supplementation in Ameliorating Propionic Acid-Induced Behavioral and Biochemical Autistic Features in Juvenile Male Rats
Gut microbiota plays a major role in neurological disorders, including autism. Modulation of the gut microbiota through fecal microbiota...
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Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation
Neurodegenerative diseases are characterized by neuronal impairment and loss of function, and with the major shared histopathological hallmarks of...
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Association of fecal short-chain fatty acids with clinical severity and gut microbiota in essential tremor and its difference from Parkinson’s disease
Diagnosis of essential tremor (ET) at an early stage can be difficult, especially when distinguishing it from healthy controls (HCs) and Parkinson’s...
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Effect of fecal microbiota transplantation in patients with slow transit constipation and the relative mechanisms based on the protein digestion and absorption pathway
BackgroundFecal microbiota transplantation (FMT) is considered an effective treatment for slow transit constipation (STC); nevertheless, the...
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Risk factors and molecular epidemiology of fecal carriage of carbapenem resistant Enterobacteriaceae in patients with liver disease
BackgroundCarbapenem resistant Enterobacteriaceae (CRE) colonization is a risk factor for CRE infection. CRE infection results in an increase in...
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Altered gut mycobiome in patients with end-stage renal disease and its correlations with serum and fecal metabolomes
BackgroundThe relationship between the gut mycobiome and end-stage renal disease (ESRD) remains largely unexplored.
MethodsIn this study, we...
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Fecal microbiota transplantation protects rotenone-induced Parkinson’s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis
BackgroundParkinson’s disease (PD) is a prevalent neurodegenerative disorder, displaying not only well-known motor deficits but also gastrointestinal...
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Transplant of fecal microbiota from healthy young mice relieves cognitive defects in late-stage diabetic mice by reducing metabolic disorders and neuroinflammation
Fecal microbiota transplant (FMT) is becoming as a promising area of interest for treating refractory diseases. In this study, we investigated the...
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Strain engraftment competition and functional augmentation in a multi-donor fecal microbiota transplantation trial for obesity
BackgroundDonor selection is an important factor influencing the engraftment and efficacy of fecal microbiota transplantation (FMT) for complex...
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Predictive value of fecal calprotectin and lactoferrin levels for negative outcomes in Clostridioides difficile infection
PurposeWe investigated the role of fecal calprotectin (FC) and lactoferrin (FL) as predictive biomarkers in Clostridioides difficile infection (CDI).
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Engraftment of essential functions through multiple fecal microbiota transplants in chronic antibiotic-resistant pouchitis—a case study using metatranscriptomics
BackgroundIleal pouch-anal anastomosis (IPAA) is the standard of care after total proctocolectomy for ulcerative colitis (UC). Around 50% of patients...
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Perturbed gut microbiome and fecal and serum metabolomes are associated with chronic kidney disease severity
BackgroundChronic kidney disease (CKD) is a severe public health problem associated with a disordered gut microbiome. However, the functional...
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Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial
Fecal microbial transplantation (FMT) from lean donors to patients with obesity has been associated with metabolic benefits, yet results so far have...
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Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury
BackgroundThe gut microbiota plays a critical role in regulating brain function through the microbiome-gut-brain axis (MGBA). Dysbiosis of the gut...
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Fecal microbiota transplantation in gastrointestinal disorders: time for precision medicine
Fecal microbiota transplantation (FMT) has demonstrated efficacy in treating inflammatory bowel diseases and irritable bowel syndrome in an...
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Cord Blood Transplantation for Very Early-Onset Inflammatory Bowel Disease Caused by Interleukin-10 Receptor Deficiency
PurposeInterleukin-10 receptor (IL-10R) deficiency can result in life-threatening very early-onset inflammatory bowel disease (VEO-IBD). Umbilical...
