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A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer
BackgroundMolecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers....
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Opposing roles by KRAS and BRAF mutation on immune cell infiltration in colorectal cancer – possible implications for immunotherapy
BackgroundThe immune response has important clinical value in colorectal cancer (CRC) in both prognosis and response to immunotherapy. This study...
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FAS-mediated circRNA-miRNA-mRNA Crosstalk Network Regulates Immune Cell Infiltration in Cerebral Infarction
New data are accumulating on the involvement of interaction among circular RNAs (circRNAs), microRNAs (miRNAs/miRs), and messenger RNAs (mRNAs) in...
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ZEB family is a prognostic biomarker and correlates with anoikis and immune infiltration in kidney renal clear cell carcinoma
BackgroundZinc finger E-box binding homEeobox 1 (ZEB1) and ZEB2 are two anoikis-related transcription factors. The mRNA expressions of these two...
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Identification of a novel lymphangiogenesis signature associated with immune cell infiltration in colorectal cancer based on bioinformatics analysis
BackgroundLymphangiogenesis plays an important role in tumor progression and is significantly associated with tumor immune infiltration. However, the...
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PES1 reduces CD8+ T cell infiltration and immunotherapy sensitivity via interrupting ILF3-IL15 complex in esophageal squamous cell carcinoma
BackgroundAlthough immune checkpoint blockade (ICB) therapy has brought survival benefits to patients with specific cancer types, most of cancer...
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High MICAL1 expression correlates with cancer progression and immune infiltration in renal clear cell carcinoma
BackgroundMolecule interacting with CasL 1 (MICAL1), a multidomain flavoprotein monooxygenase, is strongly involved in the biological processes...
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Intratumoral fibrosis and patterns of immune infiltration in clear cell renal cell carcinoma
BackgroundIntratumoral fibrosis was positively correlated with histological grade of renal clear cell carcinoma (ccRCC) and intratumoral...
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Identification of Age-Related Characteristic Genes Involved in Severe COVID-19 Infection Among Elderly Patients Using Machine Learning and Immune Cell Infiltration Analysis
Elderly patients infected with severe acute respiratory syndrome coronavirus 2 are at higher risk of severe clinical manifestation, extended...
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AVPR2 is a potential prognostic biomarker and correlated with immune infiltration in head and neck squamous cell carcinoma
PurposeTo explore the potential of AVPR2 in the immunotherapy of head and neck squamous cell carcinoma (HNSCC), thus providing insights into a novel...
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Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches
BackgroundThe immune cell compartment of the mammalian brain changes dramatically and peripheral T cells infiltrate the brain parenchyma during...
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ORC6, a novel prognostic biomarker, correlates with T regulatory cell infiltration in prostate adenocarcinoma: a pan-cancer analysis
BackgroundThe origin recognition complex (ORC), a six-subunit DNA-binding complex, participates in DNA replication in cancer cells. Specifically in...
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COPS6 promotes tumor progression and reduces CD8+ T cell infiltration by repressing IL-6 production to facilitate tumor immune evasion in breast cancer
Due to poor T cell infiltration, tumors evade immune surveillance. Increased CD8 + T cell infiltration in breast cancer suggests a satisfactory...
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Identification and validation of eight lysosomes-related genes signatures and correlation with immune cell infiltration in lung adenocarcinoma
Lung cancer is the leading cause of cancer-related death. Lysosomes are key degradative compartments that maintain protein homeostasis. In current...
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Galectin-9 expression clinically associated with mature dendritic cells infiltration and T cell immune response in colorectal cancer
BackgroundGalectin-9 is a member of the galectin family and has been reported to have a tumor-promoting or antitumor effect in response to the immune...
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Immune cell infiltration and drug response in glioblastoma multiforme: insights from oxidative stress-related genes
BackgroundGBM, also known as glioblastoma multiforme, is the most prevalent and lethal type of brain cancer. The cell proliferation, invasion,...
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Utilizing Machine Learning to Identify Biomarkers of Endoplasmic Reticulum Stress and Analyze Immune Cell Infiltration in Parkinson’s Disease
The neurodegenerative disorder known as Parkinson’s disease (PD) affects many people. The objective of this investigation was to examine the...
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CircHSPB6 Promotes Tumor-Associated Macrophages M2 Polarization and Infiltration to Accelerate Cell Malignant Properties in Lung Adenocarcinoma by CCL2
Circular RNAs (circRNAs) are reported to be involved in the tumorigenesis of lung adenocarcinoma (LUAD). Here, this study focused on studying the...
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Meteorin-like protein overexpression ameliorates fulminant hepatitis in mice by inhibiting chemokine-dependent immune cell infiltration
Myokines, which are recently identified cytokines secreted by skeletal muscle in response to stimulation, are crucial for the maintenance of liver...
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BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8+ T cell infiltration in colorectal cancer
BackgroundBRAF non-V600 mutation occupies a relatively small but critical subset in colorectal cancer (CRC). However, little is known about the...
