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Basic Concepts on 3D Cell Culture
This textbook shall introduce the students to 3D cell culture approaches and applications. An overview on existing techniques and equipment is...
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Exploring the interaction between extracellular matrix components in a 3D organoid disease model to replicate the pathophysiology of breast cancer
In vitro models are necessary to study the pathophysiology of the disease and the development of effective, tailored treatment methods owing to the...
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3D Printing of Microbial Polysaccharides
From the last three decades, innovative 3D printing processes have been progressively more investigated for food and regenerative medicine topics due...
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Modular air–liquid interface aerosol exposure system (MALIES) to study toxicity of nanoparticle aerosols in 3D-cultured A549 cells in vitro
We present a novel lung aerosol exposure system named MALIES (modular air–liquid interface exposure system), which allows three-dimensional...
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Platelet lysate can support the development of a 3D-engineered skin for clinical application
Safety concerns associated with foetal bovine serum (FBS) have restricted its translation into clinics. We hypothesised that platelet lysate (PL) can...
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Performance of Manufacturer Cleaning Recommendations Applied to 3D Food Ink Capsules for the Control of a Human Norovirus Surrogate
With the widespread availability of 3D food printing systems for purchase, users can customize their food in new ways. Manufacturer recommendations...
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3D-Bioprinting
Bioprinting is a digital biofabrication method that is applied to generate complex and heterogenic 3D cell culture systems and living tissues. It...
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Hydrogels for 3D Cell Culture
One of the fast growing 3D mammalian cell culture platforms are hydrogels—three-dimensional, crosslinked networks of polymers. In this chapter we...
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Towards better prediction of xenobiotic genotoxicity: CometChip technology coupled with a 3D model of HepaRG human liver cells
Toxicology is facing a major change in the way toxicity testing is conducted by moving away from animal experimentation towards animal-free methods....
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Application of Scaffold-Free 3D Models
This chapter will provide an overview on scaffold-free 3D models focusing on aggregates, spheroids, and organoids. While often used synonymously, the...
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A 3D Biomimetic System for Testing Anticancer Drug Sensitivity
3DCell culture3D cultures of cancer cells enable better mimicking of physiological conditions compared to traditional monolayer 2DCell culture2D...
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Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids
The pregnane X receptor (PXR) is a ligand-activated nuclear receptor controlling hepatocyte expression of numerous genes. Although expression changes...
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Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances
The micronucleus (MN) assay is widely used as part of a battery of tests applied to evaluate the genotoxic potential of chemicals, including new food...
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In vitro modeling of liver fibrosis in 3D microtissues using scalable micropatterning system
Liver fibrosis is the late consequence of chronic liver inflammation which could eventually lead to cirrhosis, and liver failure. Among various...
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Optimisation of the HepaRG cell line model for drug toxicity studies using two different cultivation conditions: advantages and limitations
The HepaRG cell line represents a successful model for hepatotoxicity studies. These cells are of human origin and are differentiated in vitro into...
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Pre-clinical 2D and 3D toxicity response to a panel of nanomaterials; comparative assessment of NBM-induced liver toxicity
Nanobiomaterials, or NBMs, have been used in medicine and bioimaging for decades, with wide-reaching applications ranging from their uses as carriers...
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Lab Equipment for 3D Cell Culture
When starting to work with 3D cell cultures it is essential to be aware of the differences to common 2D cultures in terms of expenses and equipment...
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3D bioprinting of complex tissues in vitro: state-of-the-art and future perspectives
The pharmacology and toxicology of a broad variety of therapies and chemicals have significantly improved with the aid of the increasing in vitro...
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3D Printing of Microbial Polysaccharides
From the last three decades, innovative 3D printing processes have been progressively more investigated for food and regenerative medicine topics due...
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3D culture conditions support Kaposi’s sarcoma herpesvirus (KSHV) maintenance and viral spread in endothelial cells
AbstractKaposi’s sarcoma–associated herpesvirus (KSHV) is a human tumorigenic virus and the etiological agent of an endothelial tumor (Kaposi’s...
