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Effects of Commonly used Surfactants, Poloxamer 188 and Tween 80, on the Drug Transport Capacity of Intestinal Glucose Transporters
Some glycoside drugs can be transported through intestinal glucose transporters (IGTs). The surfactants used in oral drug preparations can affect the...
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Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension
This study employed a Quality by Design (QbD) approach to spray dry amorphousclotrimazole nanosuspension (CLT-NS) consisting of Soluplus ® and...
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Duo photoprotective effect via silica-coated zinc oxide nanoparticles and Vitamin C nanovesicles composites
ObjectiveZinc Oxide nanoparticles (ZnO NPs) are used widely in nowadays personal care products, especially sunscreens, as a protector against UV...
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Thiamylal serum concentration for refractory convulsive status epilepticus while associated decreased concentrations of concomitant antiepileptics: a case report
BackgroundTreating refractory status epilepticus (RSE) remains a challenge. Thiamylal can be used as a second- or third-line treatment; however, its...
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Preparation of Microsponge Drug Delivery System (MSDDS) Followed by a Scale-Up Approach
In 1987, Won invented the solid-phase porous microsphere (MS), which stores bioactive compounds in many interconnected voids. Spherical particles...
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HSPiP, Computational, and Thermodynamic Model–Based Optimized Solvents for Subcutaneous Delivery of Tolterodine Tartrate and GastroPlus‑Based In Vivo Prediction in Humans: Part II
In part I, we reported Hansen solubility parameters (HSP, HSPiP program), experimental solubility at varied temperatures for TOTA delivery. Here, we...
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Kinetic Modeling for BT200 to Predict the Level of Plasma-Derived Coagulation Factor VIII in Humans
Lack of Factor VIII (FVIII) concentrates is one of limiting factors for Hemophilia A prophylaxis in resource-limited countries. Rondaptivon pegol...
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Neutralizing Antibody Sample Testing and Report Harmonization
Immunogenicity testing and characterization is an important part of understanding the immune response to administration of a protein therapeutic....
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Nanosuspension-Based Repaglinide Fast-Dissolving Buccal Film for Dissolution Enhancement
Drug solubility and dissolution remain a significant challenge in pharmaceutical formulations. This study aimed to formulate and evaluate...
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Exploring factors associated with bleeding events after open heart surgery in patients on dialysis − effects of the presence or absence of warfarin therapy
BackgroundPerioperative management of patients on dialysis is critical for controlling bleeding and thrombotic risk, in addition to infection...
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Establishing Virtual Bioequivalence and Clinically Relevant Specifications for Omeprazole Enteric-Coated Capsules by Incorporating Dissolution Data in PBPK Modeling
Currently, Biopharmaceutics Classification System (BCS) classes I and III are the only biological exemptions of immediate-release solid oral dosage...
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Understand the Stabilization Engineering of Ascorbic Acid, Map** the Scheme for Stabilization, and Advancement.
AbstractVitamin C is extensively used in cosmetic formulation, howbeit stability is the supreme demerit that limits its use in beautifying products....
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In Vitro Ciclopirox Glucuronidation in Liver Microsomes from Humans and Various Experimental Animals
Background and ObjectiveCiclopirox is a widely used antifungal drug, redisposition of which has drawn increasing attentions due to multiple promising...
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Knockout Transporter Cell Lines to Assess Substrate Potential Towards Efflux Transporters
P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance transporter 2 (MRP2) are efflux transporters involved in the...
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CONUT score as a predictor for anamorelin efficacy in patients with cancer cachexia receiving chemotherapy
BackgroundAnamorelin is expected to improve cancer cachexia by increasing lean body mass (LBM) due to increased appetite and protein synthesis....
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Influence of ensitrelvir or nirmatrelvir/ritonavir on tacrolimus clearance in kidney transplant recipients: a single-center case series
BackgroundAmong the oral antivirals used for treating patients with mild-to-moderate novel coronavirus disease 2019 (COVID-19),...
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Pharmacokinetic Modeling of the Effect of Tariquidar on Ondansetron Disposition into the Central Nervous System
PurposeSerotonin (5-HT 3 ) receptor antagonists are promising agents for treatment of neuropathic pain. However, insufficient drug exposure at the...
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Intact NMR Approach Quickly Reveals Synchronized Microstructural Changes in Oil-in-Water Nanoemulsion Formulations
A soft-core oil-in-water (o/w) nanoemulsion (NE) is composed of nanometer (nm) sized oil droplets, stabilized by a surfactant layer and dispersed in...
