Search
Search Results
-
High-dimensional single-cell analysis of human natural killer cell heterogeneity
Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to microbes and tumors. Historically, their...
-
Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference map**
The functional diversity of natural killer (NK) cell repertoires stems from differentiation, homeostatic, receptor–ligand interactions and...
-
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial
Preclinical evidence demonstrates that senescent cells accumulate with aging and that senolytics delay multiple age-related morbidities, including...
-
Neoadjuvant chemotherapy with or without camrelizumab in resectable esophageal squamous cell carcinoma: the randomized phase 3 ESCORT-NEO/NCCES01 trial
Recent single-arm studies involving neoadjuvant camrelizumab, a PD-1 inhibitor, plus chemotherapy for resectable locally advanced esophageal squamous...
-
Benefits for children with suspected cancer from routine whole-genome sequencing
Clinical whole-genome sequencing (WGS) has been shown to deliver potential benefits to children with cancer and to alter treatment in high-risk...
-
A new tau dephosphorylation-targeting chimera for the treatment of tauopathies
Abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies,...
-
Genetic Evaluation of the Patients with Clinically Diagnosed Inborn Errors of Immunity by Whole Exome Sequencing: Results from a Specialized Research Center for Immunodeficiency in Türkiye
Molecular diagnosis of inborn errors of immunity (IEI) plays a critical role in determining patients’ long-term prognosis, treatment options, and...
-
Is Culex modestus a New Usutu virus vector?
Usutu virus is an emerging pathogen transmitted by mosquitoes. Culex modestus mosquitoes are widespread in Europe, but their role in disease...
-
A modified mycobacterial growth inhibition assay for the functional assessment of vaccine-mediated immunity
The Mycobacterial growth inhibition assay (MGIA) is an ex-vivo assay used to measure the overall functional immune response elicited by infection or...
-
Diversity of group 1 innate lymphoid cells in human tissues
Group 1 innate lymphoid cells (ILC1s) are cytotoxic and interferon gamma-producing lymphocytes lacking antigen-specific receptors, which include...
-
Healthcare system resilience and adaptability to pandemic disruptions in the United States
Understanding healthcare system resilience has become paramount, particularly in the wake of the COVID-19 pandemic, which imposed unprecedented...
-
Transmission dynamics of avian influenza viruses in Egyptian poultry markets
Live bird markets (LBMs) are considered hotspots for Avian Influenza Viruses (AIVs). In such markets, AIVs pose threats to both poultry and public...
-
Emerging paradigms: unmasking the role of oxidative stress in HPV-induced carcinogenesis
The contribution of the human papillomavirus (HPV) to cancer is significant but not exclusive, as carcinogenesis involves complex mechanisms, notably...
-
Mitochondrial genome of the fluke pond snail, Austropeplea cf. brazieri (Gastropoda: Lymnaeidae)
BackgroundLymnaeid snails of the genus Austropeplea are an important vector of the liver fluke ( Fasciola hepatica ), contributing to livestock...
-
Continuous neural control of a bionic limb restores biomimetic gait after amputation
For centuries scientists and technologists have sought artificial leg replacements that fully capture the versatility of their intact biological...
-
Disparities in air pollution attributable mortality in the US population by race/ethnicity and sociodemographic factors
There are large differences in premature mortality in the USA by race/ethnicity, education, rurality and social vulnerability index groups. Using...
-
Diagnostic performance of an ultra-sensitive RDT and a conventional RDT in malaria mass testing, treatment and tracking interventions in southern Ghana
BackgroundApplication of numerous malaria control interventions has led to reduction in clinical malaria cases and deaths but also the realisation...
-
Lymphocyte-Directed Immunomodulation Remits Thymoma-Associated Autoimmune Pneumonitis
BackgroundThymoma presents with several autoimmune manifestations and is associated with secondary autoimmune regulator (AIRE) deficiency....
