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Core principles of Malakit intervention for transferability in other contexts
To eliminate malaria, all populations must be included. For those who are not reached by the health care system, specific interventions must be...
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Multi-target measurable residual disease assessed by error-corrected sequencing in patients with acute myeloid leukemia: An ALFA study
The evaluation of measurable residual disease (MRD) in acute myeloid leukemia (AML) using comprehensive mutation analysis by next-generation...
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Premature thymic functional senescence is a hallmark of childhood acute lymphoblastic leukemia survivorship
Childhood acute lymphoblastic leukemia (cALL) survivors suffer early-onset chronic diseases classically associated with aging. Normal aging is...
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Prognostics of multiple malaria episodes and nutritional status in children aged 6 to 59 months from 2013 to 2017 in Dangassa, Koulikoro region, Mali
BackgroundIn Africa, the relationship between childhood nutritional status and malaria remains complex and difficult to interpret. Understanding it...
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Immune cell phenotypes and mortality in the Framingham Heart Study
BackgroundGlobal life expectancy is rising, with the 60 + age group projected to hit 2 billion by 2050. Aging impacts the immune system. A notable...
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Genomic tailoring of autogenous poultry vaccines to reduce Campylobacter from farm to fork
Campylobacter is a leading cause of food-borne gastroenteritis worldwide, linked to the consumption of contaminated poultry meat. Targeting this...
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Therapeutic efficacy and safety of artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria treatment in Metehara, Central-east Ethiopia
BackgroundMalaria remains a major global health problem although there was a remarkable achievement between 2000 and 2015. Malaria drug resistance,...
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Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort
Background and purposeThe immune response changes during aging and the progression of Alzheimer’s disease (AD) and related dementia (ADRD)....
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T-cell immunity induced and reshaped by an anti-HPV immuno-oncotherapeutic lentiviral vector
We recently developed an immuno-oncotherapy against human papillomavirus (HPV)-induced tumors based on a lentiviral vector encoding the Early E6 and...
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Alterations in brain fluid physiology during the early stages of development of ischaemic oedema
Oedema occurs when higher than normal amounts of solutes and water accumulate in tissues. In brain parenchymal tissue, vasogenic oedema arises from...
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Safety and efficacy of C. muridarum vaccines adjuvanted with CpG-1826 and four concentrations of Montanide-ISA-720-VG
It is recommended that the adjuvant Montanide ISA 720 VG be used at a concentration of 70% v/v. At this concentration, Montanide causes at the site...
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Multivalent mRNA-DTP vaccines are immunogenic and provide protection from Bordetella pertussis challenge in mice
Acellular multivalent vaccines for pertussis (DTaP and Tdap) prevent symptomatic disease and infant mortality, but immunity to Bordetella pertussis ...
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Chloroquine has shown high therapeutic efficacy against uncomplicated Plasmodium vivax malaria in southern Ethiopia: seven decades after its introduction
BackgroundPlasmodium vivax malaria is a leading cause of morbidity in Ethiopia. The first-line treatment for P. vivax is chloroquine (CQ) and...
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Drivers of autochthonous malaria cases over time: could the Central European present the African future?
BackgroundResults of spatial and temporal comparison of malaria hotspots and coldspots could improve the health measures of malaria control and...
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Community readiness and acceptance for the implementation of a novel malaria vaccine among at-risk children in sub-saharan Africa: a systematic review protocol
BackgroundThe World Health Organization novel malaria vaccine for at-risk children has the potential to greatly reduce the current malaria burden in...
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Pembrolizumab in patients with advanced upper tract urothelial carcinoma: a real-world study from ARON-2 project
Upper tract urothelial carcinoma (UTUC) accounts for the 5–10% of all urothelial carcinomas (UCs). In this analysis, we reported the real-world data...
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Differential long-term bivalent HPV vaccine cross-protection by variants in the Costa Rica HPV vaccine trial
The AS04-adjuvanted human papillomavirus (HPV)16/18 vaccine, an L1-based vaccine, provides strong vaccine efficacy (VE) against vaccine-targeted type...
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Knowledge of genetics and attitudes toward genetic testing among university students in Indonesia
The development in human genetics must be tracked with the knowledge to provide support and positive attitudes towards genetic research and its...
