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Pumilio-1 mediated translational control of claudin-5 at the blood-brain barrier
AbstractClaudin-5 is one of the most essential tight junction proteins at the blood-brain barrier. A single nucleotide polymorphism rs10314 is...
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Mucosal bivalent live attenuated vaccine protects against human metapneumovirus and respiratory syncytial virus in mice
Live-Attenuated Vaccines (LAVs) stimulate robust mucosal and cellular responses and have the potential to protect against Respiratory Syncytial Virus...
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Assessing CRISPR/Cas9 potential in SDG3 attainment: malaria elimination—regulatory and community engagement landscape
Elimination of malaria has become a United Nations member states target: Target 3.3 of the sustainable development goal no. 3 (SDG3). Despite the...
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Real world predictors of response and 24-month survival in high-grade TP53-mutated myeloid neoplasms
Current therapies for high-grade TP53 -mutated myeloid neoplasms (≥10% blasts) do not offer a meaningful survival benefit except allogeneic stem cell...
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Evaluation of mRNA-LNP and adjuvanted protein SARS-CoV-2 vaccines in a maternal antibody mouse model
Maternal antibodies (matAbs) protect against a myriad of pathogens early in life; however, these antibodies can also inhibit de novo immune responses...
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GFPT2 expression is induced by gemcitabine administration and enhances invasion by activating the hexosamine biosynthetic pathway in pancreatic cancer
Our previous studies revealed a novel link between gemcitabine (GEM) chemotherapy and elevated glutamine-fructose-6-phosphate transaminase 2 (GFPT2)...
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The unseen battle: interpreting the 2023 World Malaria Report from Burkina Faso's frontlines
The recently released 2023 World Malaria Report sheds light on an alarming reality: despite preventive measures, malaria remains a severe issue in...
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LLIN evaluation in Uganda project (LLINEUP2): association between housing construction and malaria burden in 32 districts
BackgroundWell-built housing limits mosquito entry and can reduce malaria transmission. The association between community-level housing and malaria...
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CD8+ T cells promote ZIKV clearance and mitigate testicular damage in mice
Zika virus (ZIKV) causes human testicular inflammation and alterations in sperm parameters and causes testicular damage in mouse models. The...
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Screening of malaria infections in human blood samples with varying parasite densities and anaemic conditions using AI-Powered mid-infrared spectroscopy
BackgroundEffective testing for malaria, including the detection of infections at very low densities, is vital for the successful elimination of the...
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Space–time clusters and co-occurrence of Plasmodium vivax and Plasmodium falciparum malaria in West Bengal, India
BackgroundMalaria, a prominent vector borne disease causing over a million annual cases worldwide, predominantly affects vulnerable populations in...
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Membrane Lipid Replacement for reconstituting mitochondrial function and moderating cancer-related fatigue, pain and other symptoms while counteracting the adverse effects of cancer cytotoxic therapy
Cancer-related fatigue, pain, gastrointestinal and other symptoms are among the most familiar complaints in practically every type and stage of...
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Immune escape of avian oncogenic Marek’s disease herpesvirus and antagonistic host immune responses
Marek’s disease virus (MDV) is a highly pathogenic and oncogenic alpha herpesvirus that causes Marek’s disease (MD), which is one of the most...
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A five years malaria surveillance data analysis of North Shewa zone, Amhara region, Ethiopia: July 2018 to June 2023
BackgroundMalaria is a critical public health concern in Ethiopia, with significant socioeconomic consequences. Malaria data trend analysis is...
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Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformers
Alzheimer’s disease (AD) and related tauopathies are associated with pathological tau protein aggregation, which plays an important role in...
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Association between antibody responses post-vaccination and severe COVID-19 outcomes in Scotland
Several population-level studies have described individual clinical risk factors associated with suboptimal antibody responses following COVID-19...
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Medicaid expansion in California and breast cancer incidence across neighborhoods with varying social vulnerabilities
PurposeTo investigate changes in breast cancer incidence rates associated with Medicaid expansion in California.
MethodsWe extracted yearly census...
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Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells
Alzheimer’s disease (AD) is a serious brain disorder characterized by the presence of beta-amyloid plaques, tau pathology, inflammation,...
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A randomized phase 1/2a trial of ExPEC10V vaccine in adults with a history of UTI
The safety, reactogenicity, and immunogenicity of 3 doses of ExPEC10V (VAC52416), a vaccine candidate to prevent invasive Escherichia coli disease,...
