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1. “Cardiac glycosides”—quo vaditis?—past, present, and future?

   Up to date, digitalis glycosides, also known as “cardiac glycosides”, are inhibitors of the Na ⁺ /K ⁺ -ATPase. They have a long-standing history as drugs...

   Julia Fender, Johanna Klöcker, ... Kristina Lorenz in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article Open access 15 July 2024
   

2. Ultrasonic Preparation of Nano-CaCO₃ Templates and Hollow Mesoporous SiO₂ Nanoparticles for Voriconazole Loading

   CaCO ₃ nanoparticles (nano-CaCO ₃ ) as nano-templates were prepared using CaCl ₂ and Na ₂ CO ₃ solutions under controlled sonication (19.5 kHz). Using the...

   **aolin Liu, Zhilin Wu, ... Giancarlo Cravotto in AAPS PharmSciTech

   Article Open access 15 July 2024
   

3. Immunogenicity of Atezolizumab: Influence of Testing Method and Sampling Frequency on Reported Anti-drug Antibody Incidence Rates

   Measurement of anti-drug antibodies (ADA) to assess the incidence of ADA in a clinical trial is a critical step in immunogenicity assessment during...

   Maxime Usdin, Valerie Quarmby, ... Patty Siguenza in The AAPS Journal

   Article 15 July 2024
   

4. GC-MS analysis and pharmacological potentiality of Lasia spinosa (L.) Thwaites leaves and fruit extracts: an in vitro and in silico studies

   Lasia spinosa ( L. spinosa ) is widely used in Asian countries for treating various diseases and as a vegetable, yet its bioactive properties remain...

   Md. Anamul Haq, Md. Eram Hosen, ... Uzzal Kumar Acharjee in In Silico Pharmacology

   Article 15 July 2024
   

5. Plasma Deoxycholic Acid Levels are Associated with Hemodynamic and Clinical Outcomes in Acute Pulmonary Embolism Patients

   This study aimed to evaluate the correlation of plasma deoxycholic acid (DCA) levels with clinical and hemodynamic parameters in acute pulmonary...

   Na Sun, Yi-Qiang Chen, ... Bing-**ang Wu in Cardiovascular Toxicology

   Article 15 July 2024
   

6. MicroRNA-143 overexpression enhances the chemosensitivity of A172 glioblastoma cells to carmustine

   As an aggressive malignancy, glioblastoma multiforme (GBM) is the most common type of brain tumor. The existing treatments have shown limited...

   Sheyda Jodeiry Zaer, Mahmoudreza Aghamaali, ... Amir Ali Mokhtarzadeh in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article 15 July 2024
   

7. A new 3D model of L929 fibroblasts microtissues uncovers the effects of Bothrops erythromelas venom and its antivenom

   In Brazil, around 80% of snakebites are caused by snakes of the genus Bothrops. A three-dimensional culture model was standardized and used to...

   F. R. S. Andrade, E. L. da Silva, ... R. J. B. Jorge in Archives of Toxicology

   Article 15 July 2024
   

8. Comparison of DNA damage in fresh and frozen blood samples: implications for the comet assay in human biomonitoring studies

   The use of the comet assay in large biomonitoring studies may present logistical and technical challenges because of the processing of numerous...

   Katarina Matković, Marko Gerić, ... Goran Gajski in Archives of Toxicology

   Article 14 July 2024
   

9. Measuring and Understanding Market Exclusivity Length for New Prescription Drugs in France, Australia, and the USA

   Background

   Originator drug manufacturers use several strategies to delay generic competition in the USA, but it remains unclear whether this results...

   Victor L. Van de Wiele, Aaron S. Kesselheim, ... Benjamin N. Rome in Pharmaceutical Medicine

   Article 14 July 2024
   

10. Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate

    The risk of the use of toxic chemicals for unlawful acts has been a matter of concern for different governments and multilateral agencies. The...

    Leandro B. Bernardo, Caio V. N. Borges, ... Daniel A. S. Kitagawa in Archives of Toxicology

    Article 14 July 2024
    

11. Potential therapeutic effects of ester derivatives of Ribavirin against SARS-CoV-2

    Ribavirin ( 1 ) esters 4–36 have been synthesized and tested for their anti-inflammatory and anti-viral properties against SARS-CoV-2. The impaired...

    Aaminat Qureshi, Samina Bano in Medicinal Chemistry Research

    Article 14 July 2024
    

12. Effects of Commonly used Surfactants, Poloxamer 188 and Tween 80, on the Drug Transport Capacity of Intestinal Glucose Transporters

    Some glycoside drugs can be transported through intestinal glucose transporters (IGTs). The surfactants used in oral drug preparations can affect the...

    Jiasheng Chen, Zhenzhen Chen, ... Zheng Cai in AAPS PharmSciTech

    Article 13 July 2024
    

13. Analysis of Oncology and Radiation Therapy Representation on the National Board of Medical Examiners Official Practice Material for the United States National Standardized Medical Board Examinations

    Radiation therapy (RT) is a critical component of multidisciplinary cancer care, but has inconsistent curricular exposure. We characterize the...

    Mary T. Mahoney, Lauren C. Linkowski, ... Malcolm D. Mattes in Journal of Cancer Education

    Article Open access 13 July 2024
    

14. The effects of empagliflozin on ventricular arrhythmias in heart failure patients with an implantable cardioverter-defibrillator: a double-blind randomized controlled trial

    Sodium-glucose transporter 2 (SGLT2) inhibitors such as empagliflozin are one of the main treatments for type 2 diabetes mellitus (DM2) and heart...

    Farshad Abedi, Amir Hooshang Mohammadpour, ... Mohammad Tayyebi in Naunyn-Schmiedeberg's Archives of Pharmacology

    Article 13 July 2024
    

15. Effects of active vitamin D analogs and calcimimetic agents on PTH and bone mineral biomarkers in hemodialysis patients with SHPT: a network meta-analysis

    Objective

    Active vitamin D analogs and calcimimetic agents are primary drugs for patients with secondary hyperparathyroidism. Due to the different...

    **ng Liu, Yichen Liu, ... Limei Zhou in European Journal of Clinical Pharmacology

    Article 13 July 2024
    

16. Identification of acrolein as a novel diagnostic odor biomarker for 1,2,3-trichloropropane-induced hepatotoxicity in Sprague Dawley rats

    Body odor is considered a diagnostic indicator of various infectious and chronic diseases. But, few studies have examined the odor markers for...

    Ji Eun Kim, Tae Ryeol Kim, ... Dae Youn Hwang in Toxicological Research

    Article 13 July 2024
    

17. Letter to the Editor

    M. J. Giménez, L. Aguilar, ... D. Sevillano in Pharmaceutical Research

    Article 13 July 2024

18. ATP-hydrolyzing, DNA-damaging and cytotoxic activities of peptide-targeted cobalt(III) complex with diethylentriamine

    Coordination complexes of cobalt represent a potential alternative to anticancer platinum-derived drugs owing to multiple activities and better...

    Marat I. Kamalov, Andrey V. Nemtarev, ... Timur I. Abdullin in Medicinal Chemistry Research

    Article 13 July 2024
    

19. How Can General Managers Best Leverage Medical Affairs Now and in the Future?

    General managers (GMs) play a crucial role as enterprise leaders of the country affiliate of multi-national pharmaceutical companies, balancing...

    Jon Zdon, Greta-James Chatgilaou, ... Josie Downey in Pharmaceutical Medicine

    Article Open access 13 July 2024
    

20. Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension

    This study employed a Quality by Design (QbD) approach to spray dry amorphousclotrimazole nanosuspension (CLT-NS) consisting of Soluplus ^® and...

    Bhavin Gajera, Harsh Shah, ... Rutesh H. Dave in AAPS PharmSciTech

    Article 13 July 2024