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USP8 promotes the tumorigenesis of intrahepatic cholangiocarcinoma via stabilizing OGT
Ubiquitination was considered to be a crucial factor in intrahepatic cholangiocarcinoma (iCCA) development. Herein, we identified Ubiquitin-specific...
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Comparative immune profiling of pancreatic ductal adenocarcinoma progression among South African patients
BackgroundPancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer characterized by an immunosuppressive microenvironment. Patients from...
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Ultrasound-based nomogram to predict the recurrence in papillary thyroid carcinoma using machine learning
Background and aimsThe recurrence of papillary thyroid carcinoma (PTC) is not unusual and associated with risk of death. This study is aimed to...
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Melanoma risk, tumour stage, and melanoma-specific mortality in individuals with diabetes: a systematic review and meta-analysis
BackgroundCancer has become the leading diabetes-related cause of death in high-income countries, and more knowledge is needed to clarify the impact...
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KK-LC-1, a biomarker for prognosis of immunotherapy for primary liver cancer
PurposeThere is mounting evidence that patients with liver cancer can benefit from Immune checkpoint inhibitors. However, due to the high cost and...
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Clinical applications of telemedicine services using a regional telemedicine platform for cancer treatment: a cross-sectional study
BackgroundTelemedicine is beneficial for improving treatment efficiency and reducing medical expenses of cancer patients. This study focuses on...
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A transversal cross-sectional study of factors related to HPV vaccination status and cancer screening participation among French women aged 25–40
BackgroundIn 2020, uterine cervical cancer (UCC) was the 12th most common cancer among women in France and the 4th worldwide. French health...
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Development and validation of a clinical nomogram to predict prostatic inflammation in men with lower urinary tract symptoms
BackgroundProstatic inflammation is an important etiological component of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS)....
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Reasons for non-feasibility of therapeutic drug monitoring of oral targeted therapies in oncology – an analysis of the closed cohorts of a multicentre prospective study
BackgroundTherapeutic drug monitoring (TDM) – performing dose adjustments based on measured drug levels and established pharmacokinetic (PK) targets...
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Machine learning-based decision support model for selecting intra-arterial therapies for unresectable hepatocellular carcinoma: A national real-world evidence-based study
ImportanceIntra-arterial therapies(IATs) are promising options for unresectable hepatocellular carcinoma(HCC). Stratifying the prognostic risk before...
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CCDC88C, an O-GalNAc glycosylation substrate of GALNT6, drives breast cancer metastasis by promoting c-JUN-mediated CEMIP transcription
Coiled-coil domain containing 88C (CCDC88C) is a component of non-canonical Wnt signaling, and its dysregulation causes colorectal cancer metastasis....
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PARP inhibition with rucaparib alone followed by combination with atezolizumab: Phase Ib COUPLET clinical study in advanced gynaecological and triple-negative breast cancers
BackgroundCombining PARP inhibitors (PARPis) with immune checkpoint inhibitors may improve clinical outcomes in selected cancers. We evaluated...
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Participants’ perspectives of being recruited into a randomised trial of a weight loss intervention before colorectal cancer surgery: a qualitative interview study
BackgroundThe period between cancer diagnosis and surgery presents an opportunity for trials to assess the feasibility of behaviour change...
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miR-455/GREM1 axis promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing M2 macrophage polarization
BackgroundColorectal cancer is among the most common malignant tumors affecting the gastrointestinal tract. Liver metastases, a complication present...
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Clinical outcome predictors for metastatic renal cell carcinoma: a retrospective multicenter real-life case series
Over the last decades, the therapeutic armamentarium of metastatic renal cell carcinoma (mRCC) has been revolutionized by the advent of...
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Exploring the causal association between uric acid and lung cancer in east Asian and European populations: a mendelian randomization study
BackgroundLung cancer still ranks first in the mortality rate of cancer. Uric acid is a product of purine metabolism in humans. Its presence in the...
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Towards targeting the breast cancer immune microenvironment
The tumour immune microenvironment is shaped by the crosstalk between cancer cells, immune cells, fibroblasts, endothelial cells and other stromal...
