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Combination of dual JAK/HDAC inhibitor with regorafenib synergistically reduces tumor growth, metastasis, and regorafenib-induced toxicity in colorectal cancer
BackgroundTreatment with regorafenib, a multiple-kinase inhibitor, to manage metastatic colorectal cancers (mCRCs) shows a modest improvement in...
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Combinatorial macrophage induced innate immunotherapy against Ewing sarcoma: Turning “Two Keys” simultaneously
BackgroundMacrophages play important roles in phagocytosing tumor cells. However, tumors escape macrophage phagocytosis in part through the...
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Potential of animal-welfare compliant and sustainably sourced serum from pig slaughter blood
The animal product most used as a stimulatory additive for cell cultivation is still fetal bovine serum (FBS). Besides the ethical concerns regarding...
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Genetic constraint at single amino acid resolution in protein domains improves missense variant prioritisation and gene discovery
BackgroundOne of the major hurdles in clinical genetics is interpreting the clinical consequences associated with germline missense variants in...
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Clinical Metagenomic Next-Generation Sequencing for Diagnosis of Central Nervous System Infections: Advances and Challenges
Central nervous system (CNS) infections carry a substantial burden of morbidity and mortality worldwide, and accurate and timely diagnosis is...
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The black box of the relationship between breast cancer patients and accompanying patients: the accompanied patients’ point of view
BackgroundThe PAROLE-Onco program was introduced in the province of Quebec, Canada in 2019. It integrates accompanying patients (APs), i.e., people...
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The obesity-related mutation gene on nonalcoholic fatty liver disease
The prevalence of overweight and obesity is increasing, leading to metabolic-associated fatty liver disease (MAFLD) characterized by excessive...
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Associations between modifiable risk factors and hepatocellular carcinoma: a trans-ancestry Mendelian randomization study
BackgroundPotentially modifiable risk factors for hepatocellular carcinoma (HCC) have been investigated in observational epidemiology studies in East...
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miRNAs: possible regulators of toll like receptors and inflammatory tumor microenvironment in colorectal cancer
BackgroundColorectal cancer (CRC) is ranked as the third most commonly diagnosed cancer and the third cause of cancer related deaths. CRC is greatly...
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Influence of cryoablation versus operation on circulating lymphocyte subsets in patients with early-stage renal cell carcinoma
Immune response is known to play an important role in local tumor control especially in renal cell carcinoma (RCC), which is considered highly...
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Immune dysfunction prior to and during vaccination in multiple myeloma: a case study based on COVID-19
Infection is the leading cause of death in multiple myeloma (MM). However, the cellular composition associated with immune dysfunction is not...
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Genomic variants associated with age at diagnosis of childhood-onset type 1 diabetes
Age at diagnosis (AAD) of Type 1 diabetes (T1D) is determined by the age at onset of the autoimmune attack and by the rate of beta cell destruction...
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Systemic therapy and radiotherapy related complications and subsequent hospitalisation rates: a systematic review
BackgroundHospitalisation resulting from complications of systemic therapy and radiotherapy places a substantial burden on the patient, society, and...
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Inhibition of autophagy induced by tetrandrine promotes the accumulation of reactive oxygen species and sensitizes efficacy of tetrandrine in pancreatic cancer
Pancreatic cancer, characterized by its poor prognosis, exhibits a marked resistance to conventional chemotherapy and immunotherapy, underscoring the...
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Mortality rate and predictors of colorectal cancer patients in Ethiopia: a systematic review and meta-analysis
IntroductionThe incidence of colorectal cancer (CRC) has been increasing in Sub-Saharan countries, including Ethiopia. However, the real mortality...
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Unmutated RRAS2 emerges as a key oncogene in post-partum-associated triple negative breast cancer
BackgroundBreast cancer (BC) is the most common cancer in women, with triple negative BC (TNBC) accounting for 20% of cases. While early detection...
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The crosstalk between immune cells and tumor pyroptosis: advancing cancer immunotherapy strategies
Pyroptosis is a cell death process characterized by cell swelling until membrane rupture and release of intracellular contents. As an effective tumor...
