Search
Search Results
-
Organic semiconductors with p-i-n structure for optoelectronic neurostimulation
An improved organic semiconductor structure has been developed by using bulk heterostructures, i.e., p - i - n junctions, for effective wireless...
-
Two-Stage Classification of Future Knee Osteoarthritis Severity After 8 Years Using MRI: Data from the Osteoarthritis Initiative
Currently, there are no methods or tools available in clinical practice for classifying future knee osteoarthritis (KOA). In this study, we aimed to...
-
Emodin alleviates intestinal ischemia–reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation
BackgroundIntestinal ischemia–reperfusion (I/R) injury is a severe vascular emergency. Previous research indicated the protective effects of Emodin...
-
Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways
Methylprednisolone (MP) is a potent glucocorticoid that can effectively inhibit immune system inflammation and brain tissue damage in Multiple...
-
Functional and clinical roles of stromal PDGF receptors in tumor biology
PDGF receptors play pivotal roles in both developmental and physiological processes through the regulation of mesenchymal cells involved in paracrine...
-
Dual targeting non-overlap** epitopes in HER2 domain IV substantially enhanced HER2/HER2 homodimers and HER2/EGFR heterodimers internalization leading to potent antitumor activity in HER2-positive human gastric cancer
BackgroundTrastuzumab and pertuzumab combination has been approved for the treatment of patients with HER2-positive metastatic breast cancer....
-
Development of a high-frequency electrosurgical device and analysis of the results of post-registration clinical trials in comparison with world analogs
The main stages and principles of development of a high-frequency electrosurgical device are described, the mechanisms of action of high-frequency...
-
A complete chromosome substitution map** panel reveals genome-wide epistasis in Arabidopsis
Chromosome substitution lines (CSLs) are tentatively supreme resources to investigate non-allelic genetic interactions. However, the difficulty of...
-
Novel drug resistance mechanisms and drug targets in BRAF-mutated peritoneal metastasis from colorectal cancer
BackgroundPatients with peritoneal metastasis from colorectal cancer (PM-CRC) have inferior prognosis and respond particularly poorly to...
-
Exploring the potential of Lactocaseibacillus rhamnosus PMC203 in inducing autophagy to reduce the burden of Mycobacterium tuberculosis
Mycobacterium tuberculosis , a lethal pathogen in human history, causes millions of deaths annually, which demands the development of new concepts of...
-
ErbB4 deficiency exacerbates olfactory dysfunction in an early-stage Alzheimer’s disease mouse model
Olfactory dysfunction is increasingly recognized as an early indicator of Alzheimer’s disease (AD). Aberrations in GABAergic function and the...
-
Neural substrates for regulating self-grooming behavior in rodents
Grooming, as an evolutionarily conserved repetitive behavior, is common in various animals, including humans, and serves essential functions...
-
Interaction between spiders and ticks—ancient arthropod predatory behavior?
Ticks are ectoparasite vectors of pathogens affecting human and animal health worldwide. Rational integration of different control interventions...
-
High positive predictive value of CNVs detected by clinical exome sequencing in suspected genetic diseases
BackgroundGenetic disorders often manifest as abnormal fetal or childhood development. Copy number variations (CNVs) represent a significant genetic...
-
