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Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis
γδ T cells play a crucial role in immune surveillance and serve as a bridge between innate and adaptive immunity. However, the metabolic requirements...
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Neuropilin-1high monocytes protect against neonatal inflammation
Neonates are susceptible to inflammatory disorders such as necrotizing enterocolitis (NEC) due to their immature immune system. The timely appearance...
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Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution
BackgroundThe tonsils operate as a protection ring of mucosa at the gates of the upper aero-digestive tract. They show similarities with lymph nodes...
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CRISPR-Cas System: A New Dawn to Combat Antibiotic Resistance
Antimicrobial resistance (AMR) can potentially harm global public health. Horizontal gene transfer (HGT), which speeds up the emergence of AMR and...
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Synthetic biology approaches for improving the specificity and efficacy of cancer immunotherapy
Immunotherapy has shown robust efficacy in treating a broad spectrum of hematological and solid cancers. Despite the transformative impact of...
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Next-Generation Anti-TNFα Agents: The Example of Ozoralizumab
Biologic therapy involving anti-tumor necrosis factor-α (anti-TNFα) agents has fundamentally changed the management of patients with immune-mediated...
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The cell biology of HIV-1 latency and rebound
Transcriptionally latent forms of replication-competent proviruses, present primarily in a small subset of memory CD4 + T cells, pose the primary...
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GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14
Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of numerous diseases. However, the precise molecular mechanisms...
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B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice
Human old aged unmutated chronic lymphocytic leukemia U-CLL are the TCL1 + ZAP70 + CD5 + B cells. Since CD5 makes the BCR signaling tolerance, ZAP70...
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Addition of inflammation-related biomarkers to the CAIDE model for risk prediction of all-cause dementia, Alzheimer’s disease and vascular dementia in a prospective study
BackgroundIt is of interest whether inflammatory biomarkers can improve dementia prediction models, such as the widely used Cardiovascular Risk...
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Cellular metabolism regulates the differentiation and function of T-cell subsets
T cells are an important component of adaptive immunity and protect the host from infectious diseases and cancers. However, uncontrolled T cell...
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The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection
The skin is the most common site of Staphylococcus aureus infection, which can lead to various diseases, including invasive and life-threatening...
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Additional Data in Expanded Patient Populations and New Indications Support the Practice of Biosimilar-to-Biosimilar Switching
As of 31 December, 2023, 31 observational studies have been published, including a total of 6081 patients who underwent a switch from one biosimilar...
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Research Advances in Stem Cell Therapy for Erectile Dysfunction
Erectile dysfunction (ED) is a common clinical condition that mainly affects men aged over 40 years. Various causes contribute to the progression of...
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