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Carotid artery transplantation of brain endothelial cells enhances neuroprotection and neurorepair in ischaemic stroke rats
Brain microvascular endothelial cells (BMECs), an important component of the neurovascular unit, can promote angiogenesis and synaptic formation in...
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Combinatorial macrophage induced innate immunotherapy against Ewing sarcoma: Turning “Two Keys” simultaneously
BackgroundMacrophages play important roles in phagocytosing tumor cells. However, tumors escape macrophage phagocytosis in part through the...
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Nano-Bacillus Calmette-Guérin immunotherapies for improved bladder cancer treatment
Cancer immunotherapy has rapidly become the fourth mainstream treatment alternative after surgery, radiotherapy, and chemotherapy, with some...
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Investigating a Novel Two-Bag N-Acetylcysteine Regimen for Acetaminophen Toxicity
BackgroundAcetaminophen toxicity remains one of the most common causes of liver failure and is treated with a course of n-acetylcysteine (NAC). This...
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Rab11b promotes M1-like macrophage polarization by restraining autophagic degradation of NLRP3 in alcohol-associated liver disease
Macrophage polarization is vital to mounting a host defense or repairing tissue in various liver diseases. Excessive activation of the NLR family...
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The role of microglia in early neurodevelopment and the effects of maternal immune activation
Activation of the maternal immune system during gestation has been associated with an increased risk for neurodevelopmental disorders in the...
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Crosstalk between gut–brain axis: unveiling the mysteries of gut ROS in progression of Parkinson’s disease
“Path to a good mood lies through the gut.” This statement seems to imply that it has long been believed that the gut is connected with the brain....
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Clinical, Immunological, and Genetic Features in Patients with NFKB1 and NFKB2 Mutations: a Systematic Review
BackgroundInborn errors of immunity (IEIs) encompass various diseases with diverse clinical and immunological symptoms. Determining the...
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Intracellular galectin interactions in health and disease
In the galectin family, a group of lectins is united by their evolutionarily conserved carbohydrate recognition domains. These polypeptides play a...
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Expanding the phenotypic spectrum of CC2D2A-related ciliopathies: a rare homozygous nonsense variant in a patient with suspected nephronophthisis
Biallelic pathogenic variants in the gene CC2D2A cause a spectrum of ciliopathies, including Joubert and Meckel syndrome, which frequently involve...
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Evaluation of the influence of the duration of the pause between the phases of depolarizing biphasic half-sinusoidal and truncated exponential defibrillation pulses on their energy efficiency
Data obtained from simulation the responses of cardiomyocytes in a state of simulated fibrillation to depolarizing biphasic half-sinusoidal and...
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Neutralizing antibody responses assessment after vaccination in people living with HIV using a surrogate neutralization assay
ObjectiveHIV has been reported to interfere with protective vaccination against multiple pathogens, usually through the decreased effectiveness of...
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A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and...
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The black box of the relationship between breast cancer patients and accompanying patients: the accompanied patients’ point of view
BackgroundThe PAROLE-Onco program was introduced in the province of Quebec, Canada in 2019. It integrates accompanying patients (APs), i.e., people...
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Human umbilical cord mesenchymal stem cells attenuate diabetic nephropathy through the IGF1R-CHK2-p53 signalling axis in male rats with type 2 diabetes mellitus
Diabetes mellitus (DM) is a disease syndrome characterized by chronic hyperglycaemia. A long-term high-glucose environment leads to reactive oxygen...
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High-sensitivity whole-mount in situ Hybridization of Mouse Oocytes and Embryos Visualizes the Super-resolution Structures and Distributions of mRNA Molecules
Mammalian oocytes accumulate more than ten thousand mRNAs, of which three to four thousand mRNAs are translationally repressed. The timings and sites...
