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Machine learning predicts peak oxygen uptake and peak power output for customizing cardiopulmonary exercise testing using non-exercise features
PurposeCardiopulmonary exercise testing (CPET) is considered the gold standard for assessing cardiorespiratory fitness. To ensure consistent...
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Revisiting reactive oxygen species production in hypoxia
Cellular responses to hypoxia are crucial in various physiological and pathophysiological contexts and have thus been extensively studied. This has...
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Racial differences in serological markers across the first year of injury in spinal cord injury: a retrospective analysis of a multi-center interventional study
Study designSecondary analysis of a randomized, multi-center, placebo-controlled study(Sygen®).
ObjectivesTo evaluate racial differences in...
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Differences in the pupillary responses to evening light between children and adolescents
BackgroundIn the mammalian retina, intrinsically-photosensitive retinal ganglion cells (ipRGC) detect light and integrate signals from rods and cones...
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Ectonucleotidase inhibitors: targeting signaling pathways for therapeutic advancement—an in-depth review
Ectonucleotidase inhibitors are a family of pharmacological drugs that, by selectively targeting ectonucleotidases, are essential in altering...
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Frequency-modulated timer regulates torpor–arousal cycles during hibernation in distinct small mammalian hibernators
Hibernation allows mammals to endure harsh seasons by reducing their basal metabolism and body temperature (Tb) to minimize energy expenditure....
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Static and temporal dynamic alterations of regional homogeneity in chronic insomnia: a resting-state fMRI study
To explore brain function alterations in chronic insomnia (CI). 65 CI patients and 48 healthy controls were included to analyze abnormal alterations...
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The Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking
The CC chemokine ligand 2 (CCL2, also known as MCP-1) and its cognate receptor CCR2 have well-characterized roles in chemotaxis. CCL2 has been...
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Alteration of Piezo1 signaling in type 2 diabetic mice: focus on endothelium and BKCa channel
Piezo1 mechanosensitive ion channel plays a important role in vascular physiology and disease. This study aimed to elucidate the altered signaling...
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A Method to Extract Task-Related EEG Feature Based on Lightweight Convolutional Neural Network
Unlocking task-related EEG spectra is crucial for neuroscience. Traditional convolutional neural networks (CNNs) effectively extract these features...
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Exploring the biomechanics and fatigue patterns of eccentric quasi-isometric muscle actions in the knee extensors and flexors
PurposeEccentric quasi-isometric (EQI) resistance training is emerging as a promising option in sports medicine and rehabilitation. Despite prior...
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Impact of Reflective Roadways on Simulated Heat Strain at the Tokyo, Paris and Los Angeles Olympics
PurposeCities are applying reflective coatings on streets in an attempt to mitigate urban heat. These coatings are also being used to try to reduce...
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Effects of Deadlift vs. Back Squat as Post-activation Performance Enhancement Protocols on Vertical Jump Performance of Competitive Male Basketball Players
Theoretically, post-activation performance enhancement (PAPE) promotes force production and power following heavy resistance training exercises....
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Left ventricle diastolic vortex ring characterization in ischemic cardiomyopathy: insight into atrio-ventricular interplay
Diastolic vortex ring (VR) plays a key role in the blood-pum** function exerted by the left ventricle (LV), with altered VR structures being...
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Relationship of peak capillary blood lactate accumulation and body composition in determining the mechanical energy equivalent of lactate during sprint cycling
AimA 15-s all-out sprint cycle test (i.e., νLa max -test) and the post-exercise change in capillary blood lactate concentration is an emerging...
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External Evaluation of Population Pharmacokinetic Models of Piperacillin in Preterm and Term Patients from Neonatal Intensive Care
Background and ObjectivesPiperacillin/tazobactam is extensively used off-label to treat late-onset neonatal sepsis, but safety and pharmacokinetic...
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Acute ingestion of acetaminophen improves cognitive and repeated high intensity short-term maximal performance in well-trained female athletes: a randomized placebo-controlled trial
This study examined the effect of acute acetaminophen (ACTP) ingestion on physical performance during the 5 m shuttle run test (5mSRT), attention,...
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Acupoint catgut embedding attenuates oxidative stress and cognitive impairment in chronic cerebral ischemia by inhibiting the Ang II/AT1R/NOX axis
Chronic cerebral ischemia (CCI) is a common neurological disorder, characterized by progressive cognitive impairment. Acupoint catgut embedding (ACE)...
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Development of autonomic heart rate modulations during childhood and adolescence
Autonomic control of heart rate is well known in adult subjects, but limited data are available on the development of the heart rate control during...
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Modeling and control of COVID-19 disease using deep reinforcement learning method
The prevalence of epidemics has been studied by researchers in various fields. In the last 2 years, the outbreak of COVID-19 has affected the health,...
