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Hydrogels for Musculoskeletal Tissue Engineering
The advancements in scaffold-supported cell therapy for musculoskeletal tissue engineering have been truly dramatic in the last couple of decades.... -
Biopolyesters in Tissue Engineering Applications
Tissue engineering is a rapidly growing interdisciplinary field of research focused on the development of vital autologous tissue through the use... -
Interfaces to Control Cell-Biomaterial Adhesive Interactions
Cell adhesion to adsorbed proteins and adhesive sequences engineered on surfaces is crucial to cellular and host responses to implanted devices,... -
Polymeric Systems for Bioinspired Delivery of Angiogenic Molecules
Growth factors are increasingly utilized to promote regeneration of lost or compromised tissues and organs. However, current strategies applying... -
Self-Assembling Nanopeptides Become a New Type of Biomaterial
Combining physics, engineering, chemistry and biology, we can now design, synthesize and fabricate biological nano-materials at the molecular... -
Modulating Extracellular Matrix at Interfaces of Polymeric Materials
As extracellular matrices (ECM) closely interact with cells in living tissues and, through this, influence essentially any aspect of life... -
Studies of the influence of the degradation of the capacitances of an inductively coupled oscillator circuit on the characteristics of the wireless power supply module of an implantable spinal cord stimulator
Numerical modeling of changes in the capacitance and equivalent resistance of an electrolytic capacitor over its operating period was performed. The...
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A medical scanner for focusing and positioning laser radiation onto a patient’s skin
A medical scanner has been developed for the treatment of pigmented, vascular, and unpigmented skin defects using a copper vapor laser at two...
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A Comprehensive on Synthesis and Antimicrobial Evaluation of Substituted-Arylideneamino-5-(5-Chlorobenzofuran-2-yl)-1, 2, 4-Triazole-3-Thiol Derivatives/ Schiff Bases
Schiff bases are well known and popular classes of organic compounds containing imine (R 2 C = NH) group that are widely used as catalysts and...
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The black box of the relationship between breast cancer patients and accompanying patients: the accompanied patients’ point of view
BackgroundThe PAROLE-Onco program was introduced in the province of Quebec, Canada in 2019. It integrates accompanying patients (APs), i.e., people...
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Strategies for modeling aging and age-related diseases
The ability to reprogram patient-derived-somatic cells to IPSCs (Induced Pluripotent Stem Cells) has led to a better understanding of aging and...
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Evaluation of the influence of the duration of the pause between the phases of depolarizing biphasic half-sinusoidal and truncated exponential defibrillation pulses on their energy efficiency
Data obtained from simulation the responses of cardiomyocytes in a state of simulated fibrillation to depolarizing biphasic half-sinusoidal and...
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Human umbilical cord mesenchymal stem cells attenuate diabetic nephropathy through the IGF1R-CHK2-p53 signalling axis in male rats with type 2 diabetes mellitus
Diabetes mellitus (DM) is a disease syndrome characterized by chronic hyperglycaemia. A long-term high-glucose environment leads to reactive oxygen...
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Expanding the phenotypic spectrum of CC2D2A-related ciliopathies: a rare homozygous nonsense variant in a patient with suspected nephronophthisis
Biallelic pathogenic variants in the gene CC2D2A cause a spectrum of ciliopathies, including Joubert and Meckel syndrome, which frequently involve...
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High-sensitivity whole-mount in situ Hybridization of Mouse Oocytes and Embryos Visualizes the Super-resolution Structures and Distributions of mRNA Molecules
Mammalian oocytes accumulate more than ten thousand mRNAs, of which three to four thousand mRNAs are translationally repressed. The timings and sites...
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A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and...
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Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells
Prime editing (PE) enables precise and versatile genome editing without requiring double-stranded DNA breaks. Here we describe the systematic...
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Associations between modifiable risk factors and hepatocellular carcinoma: a trans-ancestry Mendelian randomization study
BackgroundPotentially modifiable risk factors for hepatocellular carcinoma (HCC) have been investigated in observational epidemiology studies in East...