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  1. ErbB4 deficiency exacerbates olfactory dysfunction in an early-stage Alzheimer’s disease mouse model

    Olfactory dysfunction is increasingly recognized as an early indicator of Alzheimer’s disease (AD). Aberrations in GABAergic function and the...

    **an-hua Deng, **ng-yang Liu, ... Lei Wen in Acta Pharmacologica Sinica
    Article 09 July 2024

  2. Neural substrates for regulating self-grooming behavior in rodents

    Grooming, as an evolutionarily conserved repetitive behavior, is common in various animals, including humans, and serves essential functions...

    Guanqing Li, Chanyi Lu, ... Yun-Feng Zhang in Journal of Zhejiang University-SCIENCE B
    Article 09 July 2024

  3. Identification of Immunodominant Epitopes of Dengue Virus 2 Envelope and NS1 Proteins: Evaluating the Diagnostic Potential of a Synthetic Peptide

    Background and Objective

    Dengue is a major infectious disease with potential for outbreaks and epidemics. A specific and sensitive diagnosis is a...

    Sushmita Singha, Neena Nath, ... Shashi Baruah in Molecular Diagnosis & Therapy
    Article 09 July 2024

  4. Functional and clinical roles of stromal PDGF receptors in tumor biology

    PDGF receptors play pivotal roles in both developmental and physiological processes through the regulation of mesenchymal cells involved in paracrine...

    Carina Strell, Elisabet Rodríguez-Tomàs, Arne Östman in Cancer and Metastasis Reviews
    Article Open access 09 July 2024

  5. Dual targeting non-overlap** epitopes in HER2 domain IV substantially enhanced HER2/HER2 homodimers and HER2/EGFR heterodimers internalization leading to potent antitumor activity in HER2-positive human gastric cancer

    Background

    Trastuzumab and pertuzumab combination has been approved for the treatment of patients with HER2-positive metastatic breast cancer....

    Ruicheng Wei, Wenli Zhang, ... Yongqiang Shan in Journal of Translational Medicine
    Article Open access 09 July 2024

  6. Clinical and genomic features of Mycobacterium avium complex: a multi-national European study

    Background

    The Mycobacterium avium complex (MAC) comprises the most frequent non-tuberculous mycobacteria (NTM) in Central Europe and currently...

    Nils Wetzstein, Margo Diricks, ... Thomas A. Wichelhaus in Genome Medicine
    Article Open access 09 July 2024

  7. High positive predictive value of CNVs detected by clinical exome sequencing in suspected genetic diseases

    Background

    Genetic disorders often manifest as abnormal fetal or childhood development. Copy number variations (CNVs) represent a significant genetic...

    Yimo Zeng, Hongke Ding, ... Aihua Yin in Journal of Translational Medicine
    Article Open access 09 July 2024

  8. Two-Stage Classification of Future Knee Osteoarthritis Severity After 8 Years Using MRI: Data from the Osteoarthritis Initiative

    Currently, there are no methods or tools available in clinical practice for classifying future knee osteoarthritis (KOA). In this study, we aimed to...

    Teemu A. T. Nurmirinta, Mikael J. Turunen, ... Mika E. Mononen in Annals of Biomedical Engineering
    Article Open access 09 July 2024

  9. The role of hydrogen sulfide regulation of ferroptosis in different diseases

    Ferroptosis is a programmed cell death that relies on iron and lipid peroxidation. It differs from other forms of programmed cell death such as...

    **gwen Lian, Yuhang Chen, ... Honggang Wang in Apoptosis
    Article 09 July 2024

  11. A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression

    Background

    The aberrant expression of phosphofructokinase-platelet (PFKP) plays a crucial role in the development of various human cancers by...

    Weiwei Liu, Zhao Ding, ... Yehai Liu in Molecular Cancer
    Article Open access 09 July 2024

  12. In-depth organoid profiling of pancreatic cancer

    Ju Eun Maeng, Ja-Lok Ku in Nature Reviews Cancer
    Article 09 July 2024

  15. Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

    Background

    Enhanced glycolysis is a crucial metabolic event that drives the development of liver fibrosis, but the molecular mechanisms have not been...

    Ying Zhi, Kerui Fan, ... Li Zhang in Molecular Medicine
    Article Open access 09 July 2024

  16. Author Correction: Lisocabtagene maraleucel in follicular lymphoma: the phase 2 TRANSCEND FL study

    Franck Morschhauser, Saurabh Dahiya, ... Loretta J. Nastoupil in Nature Medicine
    Article Open access 09 July 2024

  18. Novel drug resistance mechanisms and drug targets in BRAF-mutated peritoneal metastasis from colorectal cancer

    Background

    Patients with peritoneal metastasis from colorectal cancer (PM-CRC) have inferior prognosis and respond particularly poorly to...

    Christin Lund-Andersen, Annette Torgunrud, ... Kjersti Flatmark in Journal of Translational Medicine
    Article Open access 09 July 2024

  19. Sensing and guiding cell-state transitions by using genetically encoded endoribonuclease-mediated microRNA sensors

    Precisely sensing and guiding cell-state transitions via the conditional genetic activation of appropriate differentiation factors is challenging....

    Lei Wang, Wenlong Xu, ... Ron Weiss in Nature Biomedical Engineering
    Article 09 July 2024

  20. Synthetic CT generation for pelvic cases based on deep learning in multi-center datasets

    Background and purpose

    To investigate the feasibility of synthesizing computed tomography (CT) images from magnetic resonance (MR) images in...

    **anan Li, Lecheng Jia, ... Yi Wang in Radiation Oncology
    Article Open access 09 July 2024
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