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  1. Article

    Open Access

    Xbra modulates the activity of linker region phosphorylated Smad1 during Xenopus development

    The Bmp/Smad1 pathway plays a crucial role in developmental processes and tissue homeostasis. Mitogen-activated protein kinase (Mapk)/Erk mediated phosphorylation of Smad1 in the linker region leads to Smad1 d...

    Santosh Kumar, Zobia Umair, Vijay Kumar, Ravi Shankar Goutam in Scientific Reports (2024)

  2. Article

    Open Access

    Foxd4l1.1 negatively regulates transcription of neural repressor ventx1.1 during neuroectoderm formation in Xenopus embryos

    Neuroectoderm formation is the first step in development of a proper nervous system for vertebrates. The developmental decision to form a non-neural ectoderm versus a neural one involves the regulation of BMP ...

    Shiv Kumar, Zobia Umair, Vijay Kumar, Santosh Kumar, Unjoo Lee in Scientific Reports (2020)

  3. Article

    Open Access

    Xbra and Smad-1 cooperate to activate the transcription of neural repressor ventx1.1 in Xenopus embryos

    Crosstalk of signaling pathways play crucial roles in cell proliferation, cell differentiation, and cell fate determination for development. In the case of ventx1.1 in Xenopus embryos, both BMP-4/Smad-1 and FGF/X...

    Shiv Kumar, Zobia Umair, Jaeho Yoon, Unjoo Lee, Sung Chan Kim in Scientific Reports (2018)