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Article
Open AccessTherapeutic effect of a histone demethylase inhibitor in Parkinson’s disease
Iron accumulation in the substantia nigra is recognized as a hallmark of Parkinson’s disease (PD). Therefore, reducing accumulated iron and associated oxidative stress is considered a promising therapeutic str...
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Article
Open AccessA limbic circuitry involved in emotional stress-induced grooming
Prolonged exposure to negative stressors could be harmful if a subject cannot respond appropriately. Strategies evolved to respond to stress, including repetitive displacement behaviours, are important in main...
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Article
Open AccessCystathionine β-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter
The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS−/−) mice. However, the relevant mechanisms are unknown. Here, we examined ch...
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Article
Open AccessRefinement of learned skilled movement representation in motor cortex deep output layer
The mechanisms underlying the emergence of learned motor skill representation in primary motor cortex (M1) are not well understood. Specifically, how motor representation in the deep output layer 5b (L5b) is s...
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Article
Open AccessA combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage
Association of a high-serum ferritin with poor outcome showed that iron might play a detrimental role in the brain after intracerebral hemorrhage (ICH). Here, we investigated changes in serum iron, ferritin, t...
