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Article
Evaluation of fragility fracture risk using deep learning based on ultrasound radio frequency signal
It was essential to identify individuals at high risk of fragility fracture and prevented them due to the significant morbidity, mortality, and economic burden associated with fragility fracture. The quantitat...
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Article
Re-assessment of the close relationship between serum FSH levels and semen quality: a retrospective cohort study of 11,929 Chinese men
To establish a medically valuable normal reference interval of follicle-stimulating hormone (FSH) levels in males with normal semen and to assess the predictive value of FSH in males exhibiting semen abnormali...
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Article
Clinical and genetic characteristics of CEL-MODY (MODY8): a literature review and screening in Chinese individuals diagnosed with early-onset type 2 diabetes
CEL-related maturity-onset diabetes of the young (CEL-MODY, MODY8) is a special type of monogenetic diabetes caused by mutations in the carboxyl-ester lipase (CEL) gene. This study aimed to summarize the genet...
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Article
Long-term outcomes and prognostic factors in papillary thyroid microcarcinoma patients with distant metastases
Distant metastasis from papillary thyroid microcarcinoma (PTMC) is extremely rare and the long-term outcomes and independent prognostic factors remain unclear. The present study aimed to investigate clinicopat...
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Article
Generic levothyroxine initiation and substitution among Medicare and Medicaid populations: a new user cohort study
Generic levothyroxine has been approved and available since 2004 but its substitution remains controversial. Therefore, the objective was to examine patterns of and identify factors associated with initiation ...
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Article
Effects of combined menaquinone-4 and PTH1–34 treatment on osetogenesis and angiogenesis in calvarial defect in osteopenic rats
The aim of this study was to evaluate the effect of combining human parathyroid hormone (1–34) (PTH1–34; PTH) and menaquinone-4 (MK-4) on calvarial bone defect repair in osteopenic rats.
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Article
Elevated serum IGF-1 level enhances retinal and choroidal thickness in untreated acromegaly patients
1) To compare the retinal, choroidal, Haller’s layer, and Sattler’s/choriocapillaris thicknesses of untreated acromegaly patients without chiasm compression or diabetes mellitus and healthy controls. 2) To eva...
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Article
Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus
Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. I...
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Article
Calcitriol attenuates cardiac remodeling and dysfunction in a murine model of polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a complex reproductive and metabolic disorder affecting 10 % of reproductive-aged women, and is well associated with an increased prevalence of cardiovascular risk factors. ...
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Article
High-fat diet combined with low-dose streptozotocin injections induces metabolic syndrome in Macaca mulatta
Metabolic syndrome (MetS) is associated with abdominal obesity, hyperlipidemia, insulin resistance, and type 2 diabetes mellitus, and increases the risk of cardiovascular disease. Given the complex multifacto...
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Article
WS1 gene mutation analysis of Wolfram syndrome in a Chinese patient and a systematic review of literatures
Wolfram syndrome is a rare hereditary disease characterized by diabetes mellitus and optic atrophy. The outcome of this disease is always poor. WFS1 gene mutation is the main cause of this disease. A patient w...
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Article
A primary right atrium paraganglioma in a 15-year-old patient
Thoracic pheochromocytomas account for less than 2% of reported cases, while primary cardiac paragangliomas are even rare. The following case illustrates a 15-year-old patient with primary right atrium paragan...